2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-183249
    Ac-CoA Synthase-IN-2
    		Inhibitor
    Ac-CoA Synthase-IN-2 is an Ac-CoA Synthase (ACS) inhibitor and antifungal agent. Ac-CoA Synthase-IN-2 binds in the ATP/acetyl-AMP pocket of fungal and human ACS enzymes to exert competitive inhibition with ATP, and inhibits Cryptococcus neoformans CnKbc1-mediated acetoacetate-to-aceto-acetyl CoA conversion. Ac-CoA Synthase-IN-2 can be used for the research of fungal infections.
    Ac-CoA Synthase-IN-2
  • HY-124438
    Herbicidin A
    		Inhibitor
    Herbicidin A is an adenosine-derived nucleoside antibiotic, but also is a herbicide against dicotyledonous plants. Herbicidin A can be isolated from Streptomyces scopuliridis M40.
    Herbicidin A
  • HY-N10600
    3β-Acetoxyurs-12-en-11-one
    		Inhibitor 99.34%
    3β-Acetoxyurs-12-en-11-one is a ursane triterpenoid with antimicrobial activity, can be isolated from the stem bark of Morus mesozygia and the leaves of Ficus hirta Vahl (Moraceae).
    3β-Acetoxyurs-12-en-11-one
  • HY-E71367
    Bromelain (USP)
    		Inhibitor
    Bromelain USP is an orally active proteolytic agent. Bromelain USP converts plasminogen to plasmin to support fibrinolysis, cleaves CD44 adhesion molecules from cell surfaces, and diminishes uPAR expression and uPA activity. Bromelain USP can inhibit the activity of a variety of fungi and bacteria. Bromelain USP can be used for the research of angina pectoris, atherosclerotic disease, fungal infections, bacterial infections, chronic inflammatory bowel disease, and cancer.
    Bromelain (USP)
  • HY-W004282S1
    Undecanoic acid-d3
    		Inhibitor
    Undecanoic acid-d3 (Undecanoate-d3) is the deuterium labeled Undecanoic acid (HY-W004282). Undecanoic acid is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum.
    Undecanoic acid-d<sub>3</sub>
  • HY-121169
    Amorolfine
    		Inhibitor
    Amorolfine (Ro 14-4767) is an antifungal agent. Amorolfine ameliorates the onychomycosis through inhibition of ergosterol biosynthesis. Amorolfine inhibits Candida albicans with a MIC of 0.404 µg/mL.
    Amorolfine
  • HY-118330
    Apigeninidin chloride
    		Inhibitor
    Apigeninidin (Gesneridin) chloride, a 3‐deoxyanthocyanidin, is a fungal growth inhibitor. Apigeninidin chloride is a bioactive red biocolorant.
    Apigeninidin chloride
  • HY-134339
    Dichlobentiazox
    		Inhibitor
    Dichlobentiazox (Compound B14) is a component of Fungicidal compositions. Dichlobentiazox is used in studies on plant diseases caused by phytopathogenic fungi.
    Dichlobentiazox
  • HY-17006AS
    Caspofungin-d4
    		Inhibitor
    Caspofungin-d4 (MK-0991-d4; L-743872-d4) is a deuterium labeled Caspofungin (HY-17006A). Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.
    Caspofungin-d<sub>4</sub>
  • HY-P11102
    Temporin-SHa
    		Inhibitor
    Temporin-Sha is an antibacterial peptide with extensive biological activity. Temporin-Sha exhibits broad-spectrum antibacterial activity (e.g., against L. ivanovii, MIC = 6.25 μM), and is effective against Gram-negative bacteria (such as Escherichia coli, MIC = 10 μM), including drug-resistant strains (such as Methicillin (HY-121544)-resistant Staphylococcus aureus). Temporin-Sha also has inhibitory effects on Candida albicans (MIC = 25 μM), Saccharomyces cerevisiae (MIC = 12 μM), the pre-flagellated and non-flagellated forms of Leishmania infantum (IC50 = 5-20 μM), and Trypanosoma cruzi (IC50 = 17 μM). Temporin-Sha exhibits antiviral activity against HSV-1 and has anti-cancer effects (cytotoxicity against breast cancer cells MCF-7 and lung cancer cells H460, etc.).
    Temporin-SHa
  • HY-116474R
    Viridicatol (Standard)
    		Inhibitor
    Viridicatol (Standard) is the analytical standard of Viridicatol (HY-116474). This product is intended for research and analytical applications. Viridicatol is a quinolone alkaloid with anti-inflammatory, antibacterial, antifungal, osteogenic and chondrogenic activities. Viridicatol reduces the phosphorylation levels of ERK, JNK, p38 and STAT6; inhibits MMP-2, MMP-9, NF-κB signaling pathway and PTP1B; downregulates genes related to mast cell activation; and binds to SHN3 to activate the Wnt/SHN3 signaling pathway. Viridicatol inhibits the expression of pro-inflammatory mediators and cytokines, and promotes osteogenic/chondrogenic differentiation. Viridicatol can be used in studies related to fibrosarcoma, allergy, bacterial infection, fungal infection and osteoporosis.
    Viridicatol (Standard)
  • HY-N5164
    Arborcandin E
    		Inhibitor
    Arborcandin E is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin E exhibits IC50 values of 0.1 μg/mL and 0.012 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin E has an MIC of 0.5-2 μg/mL against the genus Candida.
    Arborcandin E
  • HY-N8255
    Puupehenone
    		Inhibitor
    Puupehenone is a cytotoxic and antifungal agent present in various marine sponge species. Puupehenone exerts cytotoxic activity against leukemia, lung cancer, colon cancer and breast cancer cells, and inhibits the growth of Candida albicans. Puupehenone can be used in research related to cancers such as leukemia, lung cancer, colon cancer and breast cancer.
    Puupehenone
  • HY-N14734
    Disorazol A
    		Inhibitor
    Disorazol A1 is an tubulin inhibitor with antifungal activity. Disorazol A1 functions by inhibiting tubulin polymerization, interfering with microtubule formation, blocking mitosis, thus arresting the cell cycle at the G2/M phase and inducing apoptosis. Disorazol A1 also exhibits an inhibitory effect against L929 mouse fibroblasts with an IC50 value of 3 pM. Disorazol A1 causes the accumulation of p53 protein in the cell nucleus. Disorazol A1 is promising for research of cancers.
    Disorazol A
  • HY-N19881
    Drimenal
    		Inhibitor
    Drimenal is a pimarane-type natural sesquiterpene with antifungal activity. Drimenal inhibits the growth of yeasts and dermatophytes. Drimenal can be used for the development of pesticide candidates and in research related to fungal infections.
    Drimenal
  • HY-149844
    S-F24
    		Inhibitor
    S-F24 is an antifungal agent with excellent broad-spectrum. S-F24 inhibits CYP3A4 with an IC50 value of 0.4 μM. S-F24 displays a good safety profile with high selectivity, low hemolytic effects, and low tendency to induce resistance. S-F24 can be used for research on fungal infections.
    S-F24
  • HY-182326
    WF-3161
    		Inhibitor
    WF-3161 (FR900261) is a cyclic tetrapeptide antibiotic isolated from the fungus Petriella guttulata with anti-tumor activity. WF-3161 inhibits the growth of Trichophyton asteroides with an MIC of 3 μg/mL. WF-3161 is applicable to research related to P-388 leukemia.
    WF-3161
  • HY-N6746R
    Citrinin (Standard)
    		Inhibitor
    Citrinin (Standard) is the analytical standard of Citrinin. This product is intended for research and analytical applications. Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity.
    Citrinin (Standard)
  • HY-N18242
    Isohemigossylic acid lactone 2-methyl ether
    		Inhibitor
    Isohemigossylic acid lactone 2-methyl ether is a sesquiterpene lactone fungal inhibitor. Isohemigossylic acid lactone 2-methyl ether inhibits the conidial growth of Verticillium dahliae with a ED50 of 7.8 μg/mL. Isohemigossylic acid lactone 2-methyl ether is isolated from the roots of Bombax malbaricum(synonym Salmalia malbaricum). Isohemigossylic acid lactone 2-methyl ether is applicable to studies related to Verticillium dahliae infection.
    Isohemigossylic acid lactone 2-methyl ether
  • HY-P11399
    Tachyplesin-3
    		Inhibitor
    Tachyplesin-3 is a broad-spectrum cationic antimicrobial peptide. Tachyplesin-3 has inhibitory activity against Gram-positive bacteria, Gram-negative bacteria, fungi and enveloped viruses. Tachyplesin-3 binds to bacterial membrane lipopolysaccharides through positive charges, disrupting membrane integrity and causing leakage of cellular contents. Tachyplesin-3 interferes with bacterial adhesion and aggregation, prevents biofilm formation, and has a synergistic effect when used in combination with Piperacillin (HY-B1923) - Tazobactam (HY-B1418) (TZP).
    Tachyplesin-3
Cat. No. Product Name / Synonyms Application Reactivity