2. Metabolic Enzyme/Protease Anti-infection
  3. Acetyl-CoA synthetase Fungal
  4. Ac-CoA Synthase-IN-2

Ac-CoA Synthase-IN-2 is an Ac-CoA Synthase (ACS) inhibitor and antifungal agent. Ac-CoA Synthase-IN-2 binds in the ATP/acetyl-AMP pocket of fungal and human ACS enzymes to exert competitive inhibition with ATP, and inhibits Cryptococcus neoformans CnKbc1-mediated acetoacetate-to-aceto-acetyl CoA conversion. Ac-CoA Synthase-IN-2 can be used for the research of fungal infections.

For research use only. We do not sell to patients.

Ac-CoA Synthase-IN-2

Ac-CoA Synthase-IN-2 Chemical Structure

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Ac-CoA Synthase-IN-2 Related Antibodies

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Description

Ac-CoA Synthase-IN-2 is an Ac-CoA Synthase (ACS) inhibitor and antifungal agent. Ac-CoA Synthase-IN-2 binds in the ATP/acetyl-AMP pocket of fungal and human ACS enzymes to exert competitive inhibition with ATP, and inhibits Cryptococcus neoformans CnKbc1-mediated acetoacetate-to-aceto-acetyl CoA conversion. Ac-CoA Synthase-IN-2 can be used for the research of fungal infections[1].

In Vitro

Ac-CoA Synthase-IN-2 (Compound 13) (25-50 μM; variable incubation times) potently inhibits multiple fungal acetyl-CoA synthetases, human ACSS2, and Cryptococcus neoformans CnKbc1, with the highest potency against Coccidioides immitis CiAcs1 (IC50 = 11.9 μM) and CnKbc1 (IC50 = 8.2 μM)[1].
Ac-CoA Synthase-IN-2 (24-72 h) exhibits modest antifungal activity only against Cryptococcus neoformans H99 (MIC = 32 μg/mL)[1].
Ac-CoA Synthase-IN-2 (24 h) shows weak toxicity against HepG2 cells, failing to induce maximal LDH release even at the highest tested concentration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ac-CoA Synthase-IN-2 Related Antibodies
Molecular Weight

493.46

Formula

C25H14F3N3O3S
SMILES

O=C1NS(=O)(C2=CC=C(C=C12)N3N=C(C=C3C4=CC5=C(C6=C(C=C5)C=CC=C6)C=C4)C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ac-CoA Synthase-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-CoA Synthase-IN-2Acetyl-CoA synthetaseFungalAcsACS enzymesSaccharomyces cerevisiaeacetyl-CoA synthetasesAspergillus fumigatusCoccidioides immitishuman ACSS2Cryptococcus neoformans CnKbc1Candida albicansHepG2 cellsCryptococcus neoformansInhibitorinhibitorinhibit

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