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Art. -Nr.: HY-183249

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Ac-CoA Synthase-IN-2

Ac-CoA Synthase-IN-2 is an Ac-CoA Synthase (ACS) inhibitor and antifungal agent. Ac-CoA Synthase-IN-2 binds in the ATP/acetyl-AMP pocket of fungal and human ACS enzymes to exert competitive inhibition with ATP, and inhibits Cryptococcus neoformans CnKbc1-mediated acetoacetate-to-aceto-acetyl CoA conversion. Ac-CoA Synthase-IN-2 can be used for the research of fungal infections.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₅H₁₄F₃N₃O₃S
Molecular Weight:493.46

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ac-CoA Synthase-IN-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Ac-CoA Synthase-IN-2 (Compound 13) (25-50 μM; variable incubation times) potently inhibits multiple fungal acetyl-CoA synthetases, human ACSS2, and Cryptococcus neoformans CnKbc1, with the highest potency against Coccidioides immitis CiAcs1 (IC₅₀ = 11.9 μM) and CnKbc1 (IC₅₀ = 8.2 μM)^[1].
Ac-CoA Synthase-IN-2 (24-72 h) exhibits modest antifungal activity only against Cryptococcus neoformans H99 (MIC = 32 μg/mL)^[1].
Ac-CoA Synthase-IN-2 (24 h) shows weak toxicity against HepG2 cells, failing to induce maximal LDH release even at the highest tested concentration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 493.46
Formel C₂₅H₁₄F₃N₃O₃S
SMILES

O=C1NS(=O)(C2=CC=C(C=C12)N3N=C(C=C3C4=CC5=C(C6=C(C=C5)C=CC=C6)C=C4)C(F)(F)F)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Propp JP, et al. Optimization of Antifungal 1,5-Diaryl-Pyrazole Acetyl-CoA Synthetase Inhibitors. ACS Omega. 2026;11(16):24237-24249. Published 2026 Apr 14. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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