Ac-CoA Synthase-IN-2
Ac-CoA Synthase-IN-2 is an Ac-CoA Synthase (ACS) inhibitor and antifungal agent. Ac-CoA Synthase-IN-2 binds in the ATP/acetyl-AMP pocket of fungal and human ACS enzymes to exert competitive inhibition with ATP, and inhibits Cryptococcus neoformans CnKbc1-mediated acetoacetate-to-aceto-acetyl CoA conversion. Ac-CoA Synthase-IN-2 can be used for the research of fungal infections.
For research use only. We do not sell to patients.
- Formula: C25H14F3N3O3S
- Molecular Weight:493.46
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Ac-CoA Synthase-IN-2 (Compound 13) (25-50 μM; variable incubation times) potently inhibits multiple fungal acetyl-CoA synthetases, human ACSS2, and Cryptococcus neoformans CnKbc1, with the highest potency against Coccidioides immitis CiAcs1 (IC50 = 11.9 μM) and CnKbc1 (IC50 = 8.2 μM)[1].
Ac-CoA Synthase-IN-2 (24-72 h) exhibits modest antifungal activity only against Cryptococcus neoformans H99 (MIC = 32 μg/mL)[1].
Ac-CoA Synthase-IN-2 (24 h) shows weak toxicity against HepG2 cells, failing to induce maximal LDH release even at the highest tested concentration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 493.46
-
Formula C25H14F3N3O3S
-
SMILES
O=C1NS(=O)(C2=CC=C(C=C12)N3N=C(C=C3C4=CC5=C(C6=C(C=C5)C=CC=C6)C=C4)C(F)(F)F)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz