Temporin-SHa

Temporin-Sha (12.5 μM, 3 h) causes the bacterial membrane of Listeria ivanovii to rupture, and even after being grafted onto the gold surface, it can still kill over 75% of the bacteria^[1].
Temporin-Sha (2-1024 μg/mL, 0-24 h) has a significant antifungal effect on Fluconazole (HY-B0101)-sensitive (CaS) and Fluconazole-resistant (CaR) Candida albicans (MIC ≥ 256 μg/mL), and can inhibit the formation of CaS and CaR biofilms, it still has the ability to destroy the formed biofilms at high concentrations (1024 μg/mL)^[2].
Temporin-Sha (32-1024 μg/mL) shows no cytotoxicity against normal oral keratinocytes (NOK-si) (CC₅₀ = 3805 μg/mL) at all concentrations, and exhibits mild cytotoxicity against human gingival fibroblasts (FGH) (CC₅₀ = 492 μg/mL)^[2].
Temporin-Sha (1.25-10 μM, 25 h) significantly inhibits HSV-1 DNA replication by directly destroying the virus particles (without relying on immune regulation) in human primary keratinocytes^[3].
Temporin-Sha (2-50 μM, 0-180 min) alters efficiently the integrity of the bacterial (E. coli, S. pyogenes, K. pneumoniae, L. infantum, S. aureus, and P. aeruginosa) and parasite (T. cruzi) plasma membrane and induce apoptotic-like death in Leishmania infantum promastigotes^[4].
Temporin-Sha (0-60 days) display no propensity to promote bacterial resistance after 55 consecutive generations of culture in E. coli, unlike Ampicillin (HY-B0522)^[4].
Temporin-SHa is cytotoxic to multiple cancer cell lines with IC₅₀ values of 14.47 μM (MCF-7), 18.36 μM (HeLa) and 34.5 μM (NCI-H460) and induced cell death is mainly necrotic rather than apoptotic^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.