2. Anti-infection
  3. Fungal
  4. S-F24

S-F24 is an antifungal agent with excellent broad-spectrum. S-F24 inhibits CYP3A4 with an IC50 value of 0.4 μM. S-F24 displays a good safety profile with high selectivity, low hemolytic effects, and low tendency to induce resistance. S-F24 can be used for research on fungal infections.

For research use only. We do not sell to patients.

S-F24 Chemical Structure

S-F24 Chemical Structure

CAS No. : 2946669-78-7

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S-F24 Related Antibodies

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Description

S-F24 is an antifungal agent with excellent broad-spectrum. S-F24 inhibits CYP3A4 with an IC50 value of 0.4 μM. S-F24 displays a good safety profile with high selectivity, low hemolytic effects, and low tendency to induce resistance. S-F24 can be used for research on fungal infections[1].

In Vitro

S-F24 (10-30 μM, 48 h) has weak cytotoxicity on mammalian cells[1].
S-F24 (0.002 μg/mL, 20 passages) increases the MIC80 value against C. albicans SC5314 by 8-fold[1].
S-F24 (0.004 μg/mL, 16 h) inhibits ergosterol biosynthesis to 92.03% in C. albicans SC5314[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

S-F24 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HUVEC, MCF-10A, 16HBE, LO2
Concentration: 0.4 μM, 10-30 μM
Incubation Time: 48 h
Result: Displayed weak cytotoxicity with IC50 values ranging from 13.97 to 29.22 μM.
Inhibited CYP3A4 with an IC50 value of 0.4 μM.
In Vivo

S-F24 (1, 5 mg/kg, i.p., 5 days, daily) is widely used in treating invasive fungal infection in female IRC mice infected with C. albicans SC5314, A. fumigatus CGMCC3.7795, and multi-resistant C. albicans 24D[1].
S-F24 (0.5, 1 mg/kg, i.p., 5 days, daily) is highly efficacious in treating superficial fungal infection in female IRC mice infected with C. albicans SC5314[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mouse models infected systemically with C. albicans SC5314, or A. fumigatus CGMCC3.7795, or multi-resistant C. albicans 24D[1]
Dosage: 1, 5 mg/kg/day, continue for 5 days
Administration: Intraperitoneal injection (i.p.)
Result: Increased the median survival time (MST) to 6 days at 1.0 mg/kg/day in C. albicans SC5314 challenge.
Increased the MST in a dose-dependent manner significantly in fumigatus CGMCC3.7795 challenge.
Increased the MST to 12 days at 1.0 mg/kg/day in multi-resistant C. albicans 24D challenge.
Animal Model: C. albicans[1].
Dosage: 0.5, 1 mg/kg/day, continue for 5 days
Administration: Intraperitoneal injection (i.p.)
Result: Reduced the fungal burden significantly and showed better therapeutic effects than the Luli (HY-14283) (1 mg/kg) group.
Inhibited fungi almost completely in the group at 1.0 mg/kg.
Molecular Weight

545.42

Formula

C25H27BrF2N6O
CAS No.
SMILES

FC1=CC=C(C(F)=C1)[C@](CN2C=NC=N2)(O)CN3CCN(CC3)CCN4C5=C(C=C4)C=C(Br)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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S-F24 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-F242946669-78-7FungalHUVECMCF-10A16HBELO2selectivityinvasive and superficial fungal infection in ICR micefungal infectionInhibitorinhibitorinhibit

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