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Cat. No.: HY-149844

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S-F24

S-F24 is an antifungal agent with excellent broad-spectrum. S-F24 inhibits CYP3A4 with an IC₅₀ value of 0.4 μM. S-F24 displays a good safety profile with high selectivity, low hemolytic effects, and low tendency to induce resistance. S-F24 can be used for research on fungal infections.

For research use only. We do not sell to patients.

CAS No.: 2946669-78-7
Formula: C₂₅H₂₇BrF₂N₆O
Molecular Weight:545.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

S-F24 Chemical Structure

CAS No.: 2946669-78-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
16HBE14o-	IC₅₀	13.97 μM Compound: S-F24	Cytotoxicity against human 16HBE14o- cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against human 16HBE14o- cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 37218609]
HUVEC	IC₅₀	13.97 μM Compound: S-F24	Cytotoxicity against human HUVEC cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against human HUVEC cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 37218609]
L02	IC₅₀	13.97 μM Compound: S-F24	Cytotoxicity against human L02 cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against human L02 cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 37218609]
MCF-10A	IC₅₀	13.97 μM Compound: S-F24	Cytotoxicity against human MCF-10A cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 37218609]

In Vitro

S-F24 (10-30 μM, 48 h) has weak cytotoxicity on mammalian cells^[1].
S-F24 (0.002 μg/mL, 20 passages) increases the MIC₈₀ value against C. albicans SC5314 by 8-fold^[1].
S-F24 (0.004 μg/mL, 16 h) inhibits ergosterol biosynthesis to 92.03% in C. albicans SC5314^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HUVEC, MCF-10A, 16HBE, LO2
Concentration:

0.4 μM, 10-30 μM
Incubation Time:

48 h
Result:

Displayed weak cytotoxicity with IC₅₀ values ranging from 13.97 to 29.22 μM.
Inhibited CYP3A4 with an IC₅₀ value of 0.4 μM.

In Vivo

S-F24 (1, 5 mg/kg, i.p., 5 days, daily) is widely used in treating invasive fungal infection in female IRC mice infected with C. albicans SC5314, A. fumigatus CGMCC3.7795, and multi-resistant C. albicans 24D^[1].
S-F24 (0.5, 1 mg/kg, i.p., 5 days, daily) is highly efficacious in treating superficial fungal infection in female IRC mice infected with C. albicans SC5314^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mouse models infected systemically with C. albicans SC5314, or A. fumigatus CGMCC3.7795, or multi-resistant C. albicans 24D^[1]
Dosage:

1, 5 mg/kg/day, continue for 5 days
Administration:

Intraperitoneal injection (i.p.)
Result:

Increased the median survival time (MST) to 6 days at 1.0 mg/kg/day in C. albicans SC5314 challenge.
Increased the MST in a dose-dependent manner significantly in fumigatus CGMCC3.7795 challenge.
Increased the MST to 12 days at 1.0 mg/kg/day in multi-resistant C. albicans 24D challenge.

Animal Model:

C. albicans[1].
Dosage:

0.5, 1 mg/kg/day, continue for 5 days
Administration:

Intraperitoneal injection (i.p.)
Result:

Reduced the fungal burden significantly and showed better therapeutic effects than the Luli (HY-14283) (1 mg/kg) group.
Inhibited fungi almost completely in the group at 1.0 mg/kg.

Chemical Information

CAS No. 2946669-78-7
Molecular Weight 545.42
Formula C₂₅H₂₇BrF₂N₆O
SMILES

FC1=CC=C(C(F)=C1)[C@](CN2C=NC=N2)(O)CN3CCN(CC3)CCN4C5=C(C=C4)C=C(Br)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhu P, et al. Novel Triazoles with Potent and Broad-Spectrum Antifungal Activity In Vitro and In Vivo. J Med Chem. 2023 Jun 8;66(11):7497-7515. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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