2. Anti-infection
  3. Fungal
  4. S-F24

S-F24 is an antifungal agent with excellent broad-spectrum. S-F24 inhibits CYP3A4 with an IC50 value of 0.4 μM. S-F24 displays a good safety profile with high selectivity, low hemolytic effects, and low tendency to induce resistance. S-F24 can be used for research on fungal infections.

For research use only. We do not sell to patients.

S-F24

S-F24 Chemical Structure

CAS No. : 2946669-78-7

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S-F24 Related Antibodies

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Description

S-F24 is an antifungal agent with excellent broad-spectrum. S-F24 inhibits CYP3A4 with an IC50 value of 0.4 μM. S-F24 displays a good safety profile with high selectivity, low hemolytic effects, and low tendency to induce resistance. S-F24 can be used for research on fungal infections[1].

Cellular Effect
Cell Line Type Value Description References
16HBE14o- IC50
13.97 μM
Compound: S-F24
Cytotoxicity against human 16HBE14o- cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human 16HBE14o- cells assessed as cell viability measured after 48 hrs by MTT assay
[PMID: 37218609]
HUVEC IC50
13.97 μM
Compound: S-F24
Cytotoxicity against human HUVEC cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HUVEC cells assessed as cell viability measured after 48 hrs by MTT assay
[PMID: 37218609]
L02 IC50
13.97 μM
Compound: S-F24
Cytotoxicity against human L02 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as cell viability measured after 48 hrs by MTT assay
[PMID: 37218609]
MCF-10A IC50
13.97 μM
Compound: S-F24
Cytotoxicity against human MCF-10A cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as cell viability measured after 48 hrs by MTT assay
[PMID: 37218609]
In Vitro

S-F24 (10-30 μM, 48 h) has weak cytotoxicity on mammalian cells[1].
S-F24 (0.002 μg/mL, 20 passages) increases the MIC80 value against C. albicans SC5314 by 8-fold[1].
S-F24 (0.004 μg/mL, 16 h) inhibits ergosterol biosynthesis to 92.03% in C. albicans SC5314[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

S-F24 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HUVEC, MCF-10A, 16HBE, LO2
Concentration: 0.4 μM, 10-30 μM
Incubation Time: 48 h
Result: Displayed weak cytotoxicity with IC50 values ranging from 13.97 to 29.22 μM.
Inhibited CYP3A4 with an IC50 value of 0.4 μM.
In Vivo

S-F24 (1, 5 mg/kg, i.p., 5 days, daily) is widely used in treating invasive fungal infection in female IRC mice infected with C. albicans SC5314, A. fumigatus CGMCC3.7795, and multi-resistant C. albicans 24D[1].
S-F24 (0.5, 1 mg/kg, i.p., 5 days, daily) is highly efficacious in treating superficial fungal infection in female IRC mice infected with C. albicans SC5314[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mouse models infected systemically with C. albicans SC5314, or A. fumigatus CGMCC3.7795, or multi-resistant C. albicans 24D[1]
Dosage: 1, 5 mg/kg/day, continue for 5 days
Administration: Intraperitoneal injection (i.p.)
Result: Increased the median survival time (MST) to 6 days at 1.0 mg/kg/day in C. albicans SC5314 challenge.
Increased the MST in a dose-dependent manner significantly in fumigatus CGMCC3.7795 challenge.
Increased the MST to 12 days at 1.0 mg/kg/day in multi-resistant C. albicans 24D challenge.
Animal Model: C. albicans[1].
Dosage: 0.5, 1 mg/kg/day, continue for 5 days
Administration: Intraperitoneal injection (i.p.)
Result: Reduced the fungal burden significantly and showed better therapeutic effects than the Luli (HY-14283) (1 mg/kg) group.
Inhibited fungi almost completely in the group at 1.0 mg/kg.
Molecular Weight

545.42

Formula

C25H27BrF2N6O
CAS No.
SMILES

FC1=CC=C(C(F)=C1)[C@](CN2C=NC=N2)(O)CN3CCN(CC3)CCN4C5=C(C=C4)C=C(Br)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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S-F24 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-F242946669-78-7FungalHUVECMCF-10A16HBELO2selectivityinvasive and superficial fungal infection in ICR micefungal infectionInhibitorinhibitorinhibit

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