2. Anti-infection
  3. Fungal
  4. Puupehenone

Puupehenone is a cytotoxic and antifungal agent present in various marine sponge species. Puupehenone exerts cytotoxic activity against leukemia, lung cancer, colon cancer and breast cancer cells, and inhibits the growth of Candida albicans. Puupehenone can be used in research related to cancers such as leukemia, lung cancer, colon cancer and breast cancer.

For research use only. We do not sell to patients.

Puupehenone

Puupehenone Chemical Structure

CAS No. : 73573-17-8

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Puupehenone Related Antibodies

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Description

Puupehenone is a cytotoxic and antifungal agent present in various marine sponge species. Puupehenone exerts cytotoxic activity against leukemia, lung cancer, colon cancer and breast cancer cells, and inhibits the growth of Candida albicans. Puupehenone can be used in research related to cancers such as leukemia, lung cancer, colon cancer and breast cancer[1][2][3].

Cellular Effect
Cell Line Type Value Description References
786-0 EC50
3.3 μM
Compound: 6
Inhibition of HIF2alpha in human 786-0 cells expressing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter gene assay
Inhibition of HIF2alpha in human 786-0 cells expressing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter gene assay
[PMID: 22928967]
786-0 IC50
17.7 μM
Compound: 6
Cytotoxicity against human 786-0 cells expressing HIF2alpha after 2 days by XTT assay
Cytotoxicity against human 786-0 cells expressing HIF2alpha after 2 days by XTT assay
[PMID: 22928967]
A549 IC50
0.1 μg/mL
Compound: 1
Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
[PMID: 3655802]
A549 IC50
0.4 μg/mL
Compound: Puupehenone
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 8350092]
HCT-8 IC50
1 μg/mL
Compound: 1
Cytotoxicity against human HCT8 cells
Cytotoxicity against human HCT8 cells
[PMID: 3655802]
HL-60 IC50
27 μM
Compound: 5
Antioxidant activity against TPA-induced ROS production in human HL60 cells by 2',7'-dichlorodihydrofluorescein diacetate cellular-based assay
Antioxidant activity against TPA-induced ROS production in human HL60 cells by 2',7'-dichlorodihydrofluorescein diacetate cellular-based assay
[PMID: 12762791]
HT-29 IC50
0.2 μg/mL
Compound: Puupehenone
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
[PMID: 8350092]
KB IC50
0.5 μg/mL
Compound: 1
Cytotoxicity against human KB cells by neutral red assay
Cytotoxicity against human KB cells by neutral red assay
[PMID: 10514320]
MCF7 IC50
0.1 μg/mL
Compound: 1
Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
[PMID: 3655802]
P388 IC50
1 μg/mL
Compound: 1
Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
[PMID: 3655802]
P388 IC50
1.3 μg/mL
Compound: Puupehenone
Cytotoxicity against mouse P388 cells after 48 hrs by MTT assay
Cytotoxicity against mouse P388 cells after 48 hrs by MTT assay
[PMID: 8350092]
RCC4 IC50
18 μM
Compound: 6
Cytotoxicity against human RCC4 cells expressing HIF2alpha and HIF1alpha after 2 days by XTT assay
Cytotoxicity against human RCC4 cells expressing HIF2alpha and HIF1alpha after 2 days by XTT assay
[PMID: 22928967]
In Vitro

Puupehenone is the major metabolite isolated from two unreported Hawaiian sponges of the genus *Hyrtios*, and its structure is confirmed by comparison of NMR spectra with a standard reference substance[1].
Puupehenone exhibits cytotoxicity against P388 mouse leukemia cells, A-549 human lung cancer cells, HCT-8 human colon cancer cells, and MCF-7 human breast cancer cells in vitro[2].
Puupehenone inhibits the growth of Candida albicans in vitro, with a minimum inhibitory concentration of 3 μg/mL[2].
Puupehenone (compound 1) (serial dilution; 3 days) weakly inhibits the growth of bovine aortic endothelial cells and various human tumor cell lines, with IC50 values ranging from 5 μM to >15 μM, and shows no selectivity for endothelial cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Puupehenone Related Antibodies
In Vivo

Puupehenone (25 mg/kg; daily; 9 days) produces a T/C value of 119 in the P388 mouse leukemia in vivo model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

328.45

Formula

C21H28O3
CAS No.
SMILES

C[C@@]12[C@@]3([C@@](C)(OC=4C(=C3)C=C(O)C(=O)C4)CC[C@]1(C(C)(C)CCC2)[H])[H]
Structure Classification
Initial Source

marine sponge Hyrtios sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Puupehenone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Puupehenone73573-17-8Fungalendothelial cell differentiationlung cancerleukemiaanti-angiogenic activityHCT-8 human colon cancer cellsmammary cancerCandida albicansA-549 human lung cancer cellscolon cancerP388 mouse leukemia cellsInhibitorinhibitorinhibit

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