Phosphatase
Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.
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Phosphatase Inhibitors
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Phosphatase Agonists
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Phosphatase Antagonists
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Phosphatase Activators
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Phosphatase Modulators
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Phosphatase Chemical
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Phosphatase Inducers
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Phosphatase Degraders
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Phosphatase Controls
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Phosphatase Substrates
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Phosphatase Ligands
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Phosphatase Proteins
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Phosphatase Related Products (728)
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Recombinant Proteins (66)
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Antibodies (40)
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Related Compound Screening Libraries (1)
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PTP1B-IN-20
0 ImagesCat. No.: HY-N10648CAS No.: 3001295-81-1PTP1B-IN-20 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.05 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC50=78.0 μM), which is a key target for type 2 diabetes inhibition.
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VHR-IN-3
0 ImagesCat. No.: HY-178292CAS No.: 1191105-54-0VHR-IN-3 (Compound 1) is a selective vaccinia H1-related (VHR) phosphatase inhibitor with a Ki of 0.81 μM. VHR-IN-3 mimics the phosphate group through the sulfonic acid group and competitively binds to the catalytic active center of VHR. VHR-IN-3 can be used for the research of cervical cancer.
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Pimecrolimus (Standard)
0 ImagesSynonyms: SDZ-ASM 981 (Standard)Pimecrolimus (Standard) is the analytical standard of Pimecrolimus. This product is intended for research and analytical applications. Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active calcineurin inhibitor with a Ki of 117 nM. Pimecrolimus shows anti-inflammatory activity.
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LMPTP inhibitor 1
0 ImagesCat. No.: HY-111489CAS No.: 1908414-82-3LMPTP inhibitor 1 is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.
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Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340
0 ImagesSynonyms: Potassium phosphate monobasic, meets analytical specification of Ph. Eur., NF, E340Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 (Potassium phosphate monobasic, meets analytical specification of Ph. Eur., NF, E340) is a potassium salt. Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 activates NF-κB. Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 upregulates the expression of dental/osteogenic markers (OCN, DSP/DSPP, OSX, RUNX2, ALP) and enhances the mineralization capacity of human periodontal ligament stem cells. Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 promotes the proliferation of human periodontal ligament stem cells in logarithmic growth phase. Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 promotes the growth of somatic embryos of Dendrobium Sonia, increases leaf number, leaf length and fresh weight of tissue-cultured seedlings. Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 is applicable to periodontal disease-related research.
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C16 acid-I-{Lys(C10 diacid)}-KQELRRIGDEF
0 ImagesCat. No.: HY-P11604C16 acid-I-{Lys (C10 diacid)}-KQELRRIGDEF is a cell-permeable and internalizable PTPN1/2 inhibitor, with IC50 values of 107.6 nM and 3375 nM, respectively. C16 acid-I-{Lys (C10 diacid)}-KQELRRIGDEF restores insulin signaling in HepG2 cells. C16 acid-I-{Lys (C10 diacid)}-KQELRRIGDEF achieves glycemic control in db/db diabetic mice. C16 acid-I-{Lys (C10 diacid)}-KQELRRIGDEF can be used in the research of type 2 diabetes.
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p-Aminophenyl phosphate
0 ImagesCat. No.: HY-W554649CAS No.: 52331-30-3p-Aminophenyl phosphate is an alkaline phosphatase substrate, and can be used for the electrochemical measurement of alkaline phosphatase activity.
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SHP2-IN-42
0 ImagesCat. No.: HY-175520SHP2-IN-42 is a src homology 2 domain-containing phosphatase 2 (SHP2) inhibitor with an IC50 of 15 nM. SHP2-IN-42 inhibits cell proliferation and induces apoptosis and G1 phase cell cycle arrest. SHP2-IN-42 can be used for the research of cancer, such as acute myeloid leukemia (AML).
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Eudebeiolide B
0 ImagesCat. No.: HY-N11775CAS No.: 1934299-51-0Synonyms: Plebeiolide D
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(Rac)-RK-682
0 ImagesCat. No.: HY-135564BCAS No.: 154639-24-4(Rac)-RK-682, a racemate of RK-682, is a protein tyrosine phosphatases (PTPases) inhibitor. (Rac)-RK-682 inhibits protein tyrosine phosphatase 1B (PTP-1B), low molecular weight protein tyrosine phosphatases (LMW-PTP), and cell division cycle 25B (CDC-25B) with IC50s of 8.6 μM, 12.4 μM, and 0.7 μM, respectively.
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PTP1B-IN-36
0 ImagesCat. No.: HY-189266PTP1B-IN-36 is a PTP1B inhibitor (IC50 0.70 μM) and a SHP2-E76K inhibitor (IC50 0.36 μM). PTP1B-IN-36 exhibits broad-spectrum inhibitory activity against PTP family enzymes, including TCPTP, SHP1-PTP, SHP2-PTP, and SHP1-WT. PTP1B-IN-36 shows anticancer activity against osteosarcoma. PTP1B-IN-36 can be used for research on osteosarcoma.
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BRD4-IN-11
0 ImagesCat. No.: HY-175033BRD4-IN-11 is an orally active and selective BRD4 inhibitor (IC50 = 26.35 nM (BD1), IC50 = 72.81 nM (BD2)). BRD4-IN-11 is approximately 3- to 18-fold more potent against BRD4 than againstBRD2, BRD3, and BRDT. BRD4-IN-11 enhances H2S release and inhibits the upregulation of fibrotic markers (α-SMA and fibronectin), c-Myc, and CDC25B. BRD4-IN-11 reduces apoptosis in LO2 hepatocytes. BRD4-IN-11 significantly improves liver and lung function in a hepatopulmonary fibrosis model and can be used to study hepatopulmonary fibrosis.
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Deoxyfunicone
0 ImagesCat. No.: HY-N16415CAS No.: 137461-36-0Deoxyfunicone is a secondary fungal metabolite that inhibits PTP1B activity by binding to the active site of the enzyme with an IC50 value of 24.3µM. Deoxyfunicone has anti-inflammatory activity.
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3-Glyceroylindole
0 Images3-Glyceroylindole (Compound 17) is a monoindole alkaloid with no significant inhibitory activity against protein tyrosine phosphatase 1b (PTP1B), and its IC50 is > 20 μM.
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Calcineurin autoinhibitory peptide TFA
0 ImagesCat. No.: HY-P1247ACalcineurin autoinhibitory peptide TFA is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide TFA could protect neurons from excitatory neuronal death.
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Penpaxilloids A
0 ImagesCat. No.: HY-N12761Penpaxilloids A (Compound 1) is a non-competitive inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 8.60 μM. Penpaxilloids A can be isolated from the fungus Penicillium sp. ZYX-Z-143. Penpaxilloids A is also an α-glucosidase (α-glucosidase) inhibitor with anti-inflammatory activity.
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Licoagrochalcone A
0 ImagesCat. No.: HY-N18297CAS No.: 202815-28-9Licoagrochalcone A is a PTP1B inhibitor. Licoagrochalcone A exerts protective effects against liver cell injury induced by carbon tetrachloride and Acetaminophen (HY-66005). Licoagrochalcone A is applicable to the research of type 2 diabetes, obesity and liver injury.
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PTP1B-IN-32
0 ImagesCat. No.: HY-179285CAS No.: 2701546-87-2PTP1B-IN-32 (Compound 5G) is an uncompetitive PTP1B inhibitor, with a Ki value of 0.72 μM. PTP1B-IN-32 enhances insulin sensitivity. PTP1B-IN-32 can be used in the research of diabetes.
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Anticancer agent 142
0 ImagesCat. No.: HY-156606CAS No.: 2948338-60-9Anticancer agent 142 (compound 235) is a PTPN inhibitor, with the potential to study cancer.
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(GalNAc)3-CPT
0 ImagesCat. No.: HY-175472(GalNAc)3-CPT is a glycoconjugate prodrug that targets the asialoglyco-protein receptor (ASGR) overexpressed on hepatocytes. (GalNAc)3-CPT exhibits significant antitumor activity (IC50 value of 3.07 μM in HepG2 cells) by activating the cGAS-STING pathway and promoting CD8+ T cell infiltration into tumors, thereby inducing tumor cell apoptosis.
