2. Metabolic Enzyme/Protease PI3K/Akt/mTOR Epigenetics Membrane Transporter/Ion Channel Neuronal Signaling GPCR/G Protein
  3. Phosphatase AMPK Calcium Channel GHSR
  4. KARI 101

KARI 101 is a blood-brain barrier permeable acid sphingomyelinase (ASM) inhibitor. KARI 101 directly inhibits ASM activity and reduces ceramide production. KARI 101 induces Ca2+ mobilization, activates AMPK and triggers GHSR1α internalization. KARI 101 can be used for the research of Alzheimer's disease.

For research use only. We do not sell to patients.

KARI 101

KARI 101 Chemical Structure

CAS No. : 3061559-97-2

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KARI 101 Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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GHSR1a

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Description

KARI 101 is a blood-brain barrier permeable acid sphingomyelinase (ASM) inhibitor. KARI 101 directly inhibits ASM activity and reduces ceramide production. KARI 101 induces Ca2+ mobilization, activates AMPK and triggers GHSR1α internalization. KARI 101 can be used for the research of Alzheimer's disease[1].

In Vitro

KARI 101 binds to purified acid sphingomyelinase (ASM) protein with high affinity[1].
KARI 101 inhibits the activity of secretory acid sphingomyelinase (ASM) in the supernatant of fibroblasts from PS1 familial Alzheimer's disease[1].
KARI 101 acts as a potent GHSR1α agonist in HEK293A cells overexpressing GHSR1α, with an EC50 of 188.5 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KARI 101 Related Antibodies
Molecular Weight

298.42

Formula

C15H30N4O2
CAS No.
SMILES

OCC(C1=CN(CCCCCCCCCC)N=N1)(CO)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KARI 101 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KARI 1013061559-97-2KARI101KARI-101PhosphataseAMPKCalcium ChannelGHSRAMP-activated protein kinaseCa2+ channelsCa channelsGrowth hormone secretagogue receptorGhrelin receptorghrelin receptorceramideacid sphingomyelinaseblood-brain barriergrowth hormone secretagogue receptor 1αalzheimer's diseaseSMPD1 mRNAPS1-familial Alzheimer's disease patient fibroblastsHEK293A cellsInhibitorinhibitorinhibit

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