2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Phosphatase FAP
  4. CL 118326

CL 118326 is a potent, selective, competitive inhibitor of mammalian pancreatic phospholipase A2 (PLA2) and a weak antagonist of platelet-activating factor receptor (PAF receptor). CL 118326 competitively inhibits mammalian pancreatic PLA2 (porcine: IC50 = 1.55 μg/mL), and shows no activity against snake venom or bee venom PLA2. CL 118326 inhibits PAF-induced and thrombin-induced platelet aggregation, as well as the release of leukotriene (LTC4) and histamine from basophil-enriched leukocytes. CL 118326 can be used for research on inflammation and allergic reactions.

For research use only. We do not sell to patients.

CL 118326

CL 118326 Chemical Structure

CAS No. : 97012-61-8

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CL 118326 Related Antibodies

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Description

CL 118326 is a potent, selective, competitive inhibitor of mammalian pancreatic phospholipase A2 (PLA2) and a weak antagonist of platelet-activating factor receptor (PAF receptor). CL 118326 competitively inhibits mammalian pancreatic PLA2 (porcine: IC50 = 1.55 μg/mL), and shows no activity against snake venom or bee venom PLA2. CL 118326 inhibits PAF-induced and thrombin-induced platelet aggregation, as well as the release of leukotriene (LTC4) and histamine from basophil-enriched leukocytes. CL 118326 can be used for research on inflammation and allergic reactions[1].

In Vitro

CL 118326 (5 min) inhibits thrombin-induced (IC50 = 7.9 μM) and PAF-induced (IC50 = 5.8 μM) rabbit platelet aggregation, but does not inhibit aggregation induced by arachidonic acid or ADP, and exhibits no PAF agonist activity[1].
CL 118326 (70 min) inhibits histamine and LTC4 release from human basophil-enriched leukocytes stimulated by antigens and ionophores, with IC50 values ranging from 1.36 to 2.34 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CL 118326 Related Antibodies
In Vivo

CL 118326 (10-20 μg; intradermal injection; single administration) dose-dependently inhibits skin capillary leakage in guinea pigs induced by porcine pancreatic phospholipase A2, with the highest lesion area inhibition rate reaching 87.2% at the 10 μg dose[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hartly (male, 250-350 g)[1]
Dosage: 10 μg; 20 μg
Administration: i.d.; single coinjection with PLA2
Result: Reduced porcine pancreatic PLA2-induced skin lesion size by 60.4% (from 83.0 mm2 to 32.8 mm2) and 51.0% (from 36.4 mm2 to 17.0 mm2) in one experiment, and by 84.4% (from 124.0 mm2 to 19.3 mm2) and 87.2% (from 56.2 mm2 to 7.2 mm2) in a second experiment, for 50-unit and 25-unit PLA2 challenges respectively.
Reduced lesion size relative to controls across multiple PLA2 dose levels at 20 μg.
Molecular Weight

615.73

Formula

C28H58INO3S
CAS No.
SMILES

O=C(C)OC(CCSCCC[N+](C)(C)C)COCCCCCCCCCCCCCCCC.[I-]
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CL 118326 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CL 11832697012-61-8CL118326CL-118326PhosphataseFAPFibroblast activation proteinguinea pigleukotrieneLTC4porcine pancreatic phospholipase A2PLA2histamineADPPAFplatelet-activating factor receptorthrombinInhibitorinhibitorinhibit

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