2. Others Immunology/Inflammation Neuronal Signaling NF-κB GPCR/G Protein Metabolic Enzyme/Protease
  3. IFNAR Fluorescent Dye 5-HT Receptor Interleukin Related Reactive Oxygen Species (ROS) Environmental Pollutants
  4. Allura Red AC

Allura Red AC  (Synonyms: Allura Red AC; FD&C RED NO. 40; CI 16035)

製品番号: HY-123630 純度: 99.00%
COA 取扱説明書 Technical Support

Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety.

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Allura Red AC

Allura Red AC 構造式

CAS 番号 : 25956-17-6

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 39 在庫あり
Solution
10 mM * 1 mL in DMSO USD 39 在庫あり
Solid
50 mg $36 在庫あり
100 mg $60 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Allura Red AC 関連抗体

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5-HT Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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製品説明

Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety[1][2][3].

体外実験

Allura Red AC (1 pmol/L, 24 h) promotes 5-HT secretion, upregulates TPH1, and enhances ROS generation in BON cells (EC cell (Enterochromaffin cells) model)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Allura Red AC 関連抗体

Western Blot Analysis[3]

Cell Line: BON cells (human enterochromaffin (EC) cell model)
Concentration: 1 pmol/L
Incubation Time: 24 h
Result: Promoted 5-HT secretion.

Real Time qPCR[3]

Cell Line: BON cells (human enterochromaffin (EC) cell model)
Concentration: 1 pmol/L
Incubation Time: 24 h
Result: Upregulated TPH1 mRNA expression.
体内実験

Allura Red AC (100 ppm, Ad libitum intake for 12 weeks) exacerbates colitis in the DSS-induced colitis C57BL/6 mouse model and enhances inflammation through 5-HT-mediated mechanisms[3].
Allura Red AC (100 ppm (100 mg of Allura Red AC per 1 kg of diet), Ad libitum intake for 5 weeks) exacerbates colitis in the CD4+CD45RBhi T cell-induced colitis Rag1-/- mouse model and promotes T cell-mediated inflammation[3].
Allura Red AC (500-2000 mg/kg, p.o., single dose) shows no in vivo genotoxic potential in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DSS (HY-116282)-induced colitis C57BL/6 mouse model[3]
Dosage: 100 ppm (100 mg of Allura Red AC per 1 kg of diet)
Administration: Dietary intake, 2 weeks (84 days), followed by 3.5% DSS for 7 days
Result: Exacerbated DSS-induced colitis, reduced body weight, increased disease activity index (DAI), histological scores, and colon weight, shortened colon length, elevated colonic 5-HT, IL-1β, IL-6, and TNF-α levels.
Animal Model: CD4+CD45RBhi T cell-induced colitis Rag1-/- mouse model[3]
Dosage: 100 ppm (100 mg of Allura Red AC per 1 kg of diet)
Administration: 5 weeks, Dietary intake
Result: Promoted colitis development, increased body weight loss, disease activity index (DAI), histological scores, and colonic IL-1β, IL-6, TNF-α, and IFN-γ levels.
Animal Model: Male CD2F1 mice (8 weeks old)[2]
Dosage: 500, 1000, 2000 mg/kg
Administration: Oral gavage (p.o.), single dose
Result: Did not show genotoxicity, did not cause DNA damage, and did not induce micronuclei in bone marrow.
分子量

496.42

分子式

C18H14N2Na2O8S2
CAS 番号
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=S(C1=CC=C2C(/N=N/C3=CC(C)=C(S(=O)(O[Na])=O)C=C3OC)=C(O)C=CC2=C1)(O[Na])=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (201.44 mM; Need ultrasonic)

DMSO : 62.5 mg/mL (125.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0144 mL 10.0721 mL 20.1442 mL
5 mM 0.4029 mL 2.0144 mL 4.0288 mL
10 mM 0.2014 mL 1.0072 mL 2.0144 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.0144 mL 10.0721 mL 20.1442 mL 50.3606 mL
5 mM 0.4029 mL 2.0144 mL 4.0288 mL 10.0721 mL
10 mM 0.2014 mL 1.0072 mL 2.0144 mL 5.0361 mL
15 mM 0.1343 mL 0.6715 mL 1.3429 mL 3.3574 mL
20 mM 0.1007 mL 0.5036 mL 1.0072 mL 2.5180 mL
25 mM 0.0806 mL 0.4029 mL 0.8058 mL 2.0144 mL
30 mM 0.0671 mL 0.3357 mL 0.6715 mL 1.6787 mL
40 mM 0.0504 mL 0.2518 mL 0.5036 mL 1.2590 mL
50 mM 0.0403 mL 0.2014 mL 0.4029 mL 1.0072 mL
60 mM 0.0336 mL 0.1679 mL 0.3357 mL 0.8393 mL
80 mM 0.0252 mL 0.1259 mL 0.2518 mL 0.6295 mL
100 mM 0.0201 mL 0.1007 mL 0.2014 mL 0.5036 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Allura Red AC Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Allura Red AC25956-17-6FD&C RED NO. 40 CI 16035CI16035CI 16035CI-16035IFNARFluorescent Dye5-HT ReceptorInterleukin RelatedReactive Oxygen Species (ROS)Environmental PollutantsInterferon-α/β receptorInterferon-alpha/beta receptor Serotonin Receptor5-hydroxytryptamine ReceptorILEnvironmental Contaminantsinflammatory bowel disease (IBD)intestinal barrier functionpro-inflammatory agentInhibitorinhibitorinhibit

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