2. Anti-infection
  3. Antibiotic
  4. Annamycin

Annamycin is an anthracycline antibiotic with antitumor activity. Annamycin interacts with topoisomerase II, induces double-strand DNA breaks, triggers cell death, and exerts cytotoxic effects. In mice, Annamycin inhibits the growth of advanced subcutaneous melanoma and subcutaneous squamous cell carcinoma, and prolongs the survival of mice with subcutaneous reticulosarcoma and in lung cancer lung metastasis models. Annamycin can be used in research related to melanoma, reticulum cell sarcoma, lung cancer, non-small cell lung cancer, small cell lung cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Annamycin

Annamycin 構造式

CAS 番号 : 92689-49-1

容量 在庫状況
50 mg   お問い合わせ  
100 mg   お問い合わせ  
250 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Annamycin 関連抗体

Top Publications Citing Use of Products

Antibiotic アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Annamycin is an anthracycline antibiotic with antitumor activity. Annamycin interacts with topoisomerase II, induces double-strand DNA breaks, triggers cell death, and exerts cytotoxic effects. In mice, Annamycin inhibits the growth of advanced subcutaneous melanoma and subcutaneous squamous cell carcinoma, and prolongs the survival of mice with subcutaneous reticulosarcoma and in lung cancer lung metastasis models. Annamycin can be used in research related to melanoma, reticulum cell sarcoma, lung cancer, non-small cell lung cancer, small cell lung cancer[1][2][3].

体外実験

Multidrug-resistant KB-V1, P388/Dox, CEM/Vbl and 8226/R cells exhibit partial loss of cross-resistance to free and multilamellar liposome-encapsulated Annamycin (4 h-72 h)[1].
Annamycin (4.3 min) completely inhibits topoisomerase IIα-mediated DNA cleavage of linearized pBR322 plasmid at an incubation time of 4.3 min[2].
Annamycin (0.1-10 μM; 1 h) potently inhibits P-glycoprotein-mediated efflux in P-gp-expressing cells, with an IC50 of 0.7 μM[2].
Annamycin (4-72 h) circumvents MRP-mediated multidrug resistance in MCF-7, MCF-7/VP, UMCC-1 and UMCC-1/VP cells; it exhibits low resistance indices (1.1, 1.4, 1.3) at 4 and 72 hr exposure durations, with ID50 values ranging from 2.10 to 8.30 μg/mL depending on the cell line and exposure time[3].
Annamycin (5 μg/mL; 1 hr) induces DNA double-strand breaks in MCF-7 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Annamycin 関連抗体
体内実験

Free Annamycin (5 mg/kg; i.v.; single dose), Multilamellar liposomal Annamycin (5 mg/kg; i.v.; single dose), and Small unilamellar liposomal Annamycin (5 mg/kg; i.v.; single dose) all inhibit the growth of advanced subcutaneous B16 melanoma, among which the small unilamellar liposome-encapsulated annamycin (S-Ann) exhibits the best efficacy, with a tumor growth inhibition rate (TGI) of 74.4%[1].
Free Annamycin (4 mg/kg; i.v.; single dose), multilamellar liposomal Annamycin (4 mg/kg; i.v.; single dose), and small unilamellar liposomal Annamycin (4 mg/kg; i.v.; single dose) significantly prolong the survival time of mice subcutaneously inoculated with M5076 reticulosarcoma. Among them, small unilamellar liposome-encapsulated Annamycin (S-Ann) shows the highest efficacy, reaching an ILS of 74.4%[1].
Free Annamycin (4 mg/kg; i.v.; single), multilamellar liposomal Annamycin (4 mg/kg; i.v.; single), and small unilamellar liposomal Annamycin (4 mg/kg; i.v.; single) significantly prolong the survival of mice bearing a Lewis lung carcinoma lung metastasis model. Among them, small unilamellar liposome-encapsulated Annamycin (S-Ann) exerts the optimal efficacy, achieving an 85.3 % ILS at low inoculum dose and a 57.6 % ILS at high inoculum dose, along with the highest long-term tumor-free survival rate[1].
Free Annamycin (4 mg/kg; i.v.; weekly; 3 injections), multilamellar liposomal Annamycin (4 mg/kg; i.v.; weekly; 3 injections), and small unilamellar liposomal Annamycin (4 mg/kg; i.v.; weekly; 3 injections) all inhibit the growth of subcutaneous KB squamous cell carcinoma xenografts, among which small unilamellar liposome-encapsulated Annamycin (S-Ann) shows the highest efficacy, reaching a TGI of 87.8%[1].
Free Annamycin (4 mg/kg; i.v.; weekly; 3 injections), multilamellar liposomal Annamycin (4 mg/kg; i.v.; weekly; 3 injections), and small unilamellar liposomal Annamycin (4 mg/kg; i.v.; weekly; 3 injections) potently inhibit the growth of subcutaneous multidrug-resistant KB-V1 squamous cell carcinoma xenografts. Among them, small unilamellar liposome-encapsulated Annamycin (S-Ann) shows the best efficacy, with a TGI of 92.6% and a 19-fold reduction in tumor growth rate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, 7-8 weeks old, inoculated s.c. with 2×106 viable B16 melanoma cells)[1]
Dosage: 5 mg/kg (Free Annamycin); 5 mg/kg (Multilamellar liposomal Annamycin); 5 mg/kg (Small unilamellar liposomal Annamycin)
Administration: i.v.; single injection
Result: Produced a %TGI of 65.0 (Free Annamycin).
Produced a %TGI of 67.6 (Multilamellar liposomal Annamycin).
Produced a %TGI of 74.4 (Small unilamellar liposomal Annamycin).
Was significantly more effective than both Free Annamycin and Multilamellar liposomal Annamycin (P < 0.05, Small unilamellar liposomal Annamycin).
Animal Model: C57BL/6 (male, 7-8 weeks old, inoculated s.c. with 6×105 M5076 reticulosarcoma cells)[1]
Dosage: 4 mg/kg (Free Annamycin); 4 mg/kg (Multilamellar liposomal Annamycin); 4 mg/kg (Small unilamellar liposomal Annamycin)
Administration: i.v.; single injection
Result: Produced a %ILS of 45.6 (Free Annamycin).
Produced a %ILS of 63.2 (Multilamellar liposomal Annamycin).
Produced a %ILS of 74.4 (Small unilamellar liposomal Annamycin).
Was significantly more effective than doxorubicin (all Annamycin formulations).
Was significantly more effective than Multilamellar liposomal Annamycin and Free Annamycin (P < 0.01 between any two groups, Small unilamellar liposomal Annamycin).
Animal Model: C57BL/6×DBA2 F1 (B6D2F1) (male, 7 weeks old, inoculated i.v. with 3.6×105 or 1×106 Lewis lung carcinoma cells)[1]
Dosage: 4 mg/kg (Free Annamycin); 4 mg/kg (Multilamellar liposomal Annamycin); 4 mg/kg (Small unilamellar liposomal Annamycin)
Administration: i.v.; single injection
Result: Produced a %ILS of 39.2 with 4/10 long-term survivors (Free Annamycin, low inoculum group).
Produced a %ILS of 73.5 with 7/10 long-term survivors (Multilamellar liposomal Annamycin, low inoculum group).
Produced a %ILS of 85.3 with 8/10 long-term survivors (Small unilamellar liposomal Annamycin, low inoculum group).
Produced a %ILS of 18.7 (Free Annamycin, high inoculum group).
Produced a %ILS of 26.7 (Multilamellar liposomal Annamycin, high inoculum group).
Produced a %ILS of 57.6 (Small unilamellar liposomal Annamycin, high inoculum group).
Was significantly more effective than doxorubicin (all Annamycin formulations).
Was significantly more effective than Multilamellar liposomal Annamycin and Free Annamycin (P < 0.01 between any two groups, Small unilamellar liposomal Annamycin).
Confirmed no tumor presence in long-term survivors (autopsy).
Animal Model: nude (nu/nu) (male, 7-8 weeks old, inoculated s.c. with 0.4×106 KB squamous cell carcinoma cells)[1]
Dosage: 4 mg/kg per injection, total 12 mg/kg (Free Annamycin); 4 mg/kg per injection, total 12 mg/kg (Multilamellar liposomal Annamycin); 4 mg/kg per injection, total 12 mg/kg (Small unilamellar liposomal Annamycin)
Administration: i.v.; weekly; 3 injections
Result: Produced a %TGI of 78.6 (Free Annamycin).
Produced a %TGI of 83.2 (Multilamellar liposomal Annamycin).
Produced a %TGI of 87.8 (Small unilamellar liposomal Annamycin).
Was significantly more effective than Free Annamycin and doxorubicin (P < 0.05, Small unilamellar liposomal Annamycin).
Animal Model: nude (nu/nu) (male, 7-8 weeks old, inoculated s.c. with 5.8×106 KB-V1 multidrug-resistant squamous cell carcinoma cells)[1]
Dosage: 4 mg/kg per injection, total 12 mg/kg (Free Annamycin); 4 mg/kg per injection, total 12 mg/kg (Multilamellar liposomal Annamycin); 4 mg/kg per injection, total 12 mg/kg (Small unilamellar liposomal Annamycin)
Administration: i.v.; weekly; 3 injections
Result: Produced a %TGI of 82.3 and reduced tumor growth rate 7-fold compared to controls (Free Annamycin).
Produced a %TGI of 86.4 and reduced tumor growth rate 8-fold compared to controls (Multilamellar liposomal Annamycin).
Produced a %TGI of 92.6 and reduced tumor growth rate 19-fold compared to controls (Small unilamellar liposomal Annamycin).
Was significantly more effective than doxorubicin (P < 0.01, all Annamycin formulations).
Was significantly more effective than Free Annamycin (P < 0.01) and Multilamellar liposomal Annamycin (P < 0.05, Small unilamellar liposomal Annamycin).
臨床実験
分子量

640.37

分子式

C26H25IO11
CAS 番号
SMILES

O=C1C2=C(C(C3=CC=CC=C31)=O)C(O)=C(C4=C2O)C[C@@](C(CO)=O)(C[C@@H]4O[C@@]5(O[C@H]([C@@H]([C@H]([C@H]5I)O)O)C)[H])O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Annamycin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Annamycin92689-49-1Antibioticanthracycline antibioticKB-V1 cellsP388/Dox cellsCEM/Vblcells8226/R cellsmelanomareticulum cell sarcomalung cancernon-small cell lung cancersmall cell lung cancersarcoma
Inhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Annamycin
製品番号:
HY-13554
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.