92689-49-1
Chemical Structure
Annamycin
- CAS No.: 92689-49-1
- Formula:C26H25IO11
- Molecular Weight:640.37
IUPAC Name: (7S,9S)-7-(((2R,3R,4R,5R,6S)-4,5-dihydroxy-3-iodo-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-7,8,9,10-tetrahydrotetracene-5,12-dione
InChIKey: CIDNKDMVSINJCG-GKXONYSUSA-N
SMILES: O=C1C2=C(C(C3=CC=CC=C31)=O)C(O)=C(C4=C2O)C[C@@](C(CO)=O)(C[C@@H]4O[C@@]5(O[C@H]([C@@H]([C@H]([C@H]5I)O)O)C)[H])O
Biological Activity: Annamycin is an anthracycline antibiotic with antitumor activity. Annamycin interacts with topoisomerase II, induces double-strand DNA breaks, triggers cell death, and exerts cytotoxic effects. In mice, Annamycin inhibits the growth of advanced subcutaneous melanoma and subcutaneous squamous cell carcinoma, and prolongs the survival of mice with subcutaneous reticulosarcoma and in lung cancer lung metastasis models. Annamycin can be used in research related to melanoma, reticulum cell sarcoma, lung cancer, non-small cell lung cancer, small cell lung cancer[1][2][3].
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Annamycin | Annamycin is an anthracycline antibiotic with antitumor activity. Annamycin interacts with topoisomerase II, induces double-strand DNA breaks, triggers cell death, and exerts cytotoxic effects. In mice, Annamycin inhibits the growth of advanced subcutaneous melanoma and subcutaneous squamous cell carcinoma, and prolongs the survival of mice with subcutaneous reticulosarcoma and in lung cancer lung metastasis models. Annamycin can be used in research related to melanoma, reticulum cell sarcoma, lung cancer, non-small cell lung cancer, small cell lung cancer. | |||||||||||||||||||||
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- [1]. Zou Y, et al. Antitumor activity of free and liposome-entrapped annamycin, a lipophilic anthracycline antibiotic with non-cross-resistance properties. Cancer Res. 1994 Mar 15;54(6):1479-84. [Content Brief]
- [2]. Booser DJ, et al. Phase I study of liposomal annamycin. Cancer Chemother Pharmacol. 2000;46(5):427-32. [Content Brief]
- [3]. Perez-Soler R, et al. Annamycin circumvents resistance mediated by the multidrug resistance-associated protein (MRP) in breast MCF-7 and small-cell lung UMCC-1 cancer cell lines selected for resistance to etoposide. Int J Cancer. 1997;71(1):35-41. [Content Brief]
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