Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) 

Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) is a rat-derived IgG2a κ antibody inhibitor, targeting to mouse 4-1BBL/CD137L. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) can block 4-1BB ligand (4-1BBL) and inhibit CD4⁺ and CD8⁺ T cells. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) can be used for the researches of cancer, infection, inflammation and immunology, such as MC38 tumor, lymphocytic choriomeningitis virus (LCMV) infection and herpetic stromal keratitis (HSK)^{[1][2][3][4][5]}.

Rat IgG2a kappa

Rat IgG2a kappa, Isotype Control

Mouse

4-1BBL/CD137L

Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (5 μg/mL or 50 μg/mL, 3 days) inhibits proliferation of both CD4⁺ and CD8⁺ T cells in response to allogeneic antigen presenting cells and reduces cytotoxicity against host alloantigen in Balb/c antigen presenting cells stimulated normal C57BL/6 T cell^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (150 μg, i.p., at days -1, 1 and 3 post-infection) diminishes the magnitude of the LCMV-specific CD8+ T cell response companied with anti-OX40L (HY-P990175) in lymphocytic choriomeningitis virus (LCMV) infected Cd70/80/86^−/− mice^[1].
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (200 μg, i.p., at days 0, 3, 6 and 8) inhibits the development of HSK in HSV-1 RE strain-infected herpetic stromal keratitis (HSK) mice^[2].
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (200 μg, i.p., at days 0, 2 and 4) prolongs graft survival in Balb/c cardiac grafted C57BL/6 mice^[3].
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (100 μg/25g, i.p., daily before applying IMQ) alleviates inflammation in imiquimod (IMQ) (HY-B0180)-induced psoriasis mice^[4].
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (100 μg, i.p., at days 0 and 2) suppresses tumor growth companied with 3H3 (HY-P99119) antibody in MC38 tumor mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

21950  [NCBI]

P41274

in vivo 4-1BBL blockade; ELISA

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Welten SP, et al. The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion. Elife. 2015 Aug 11;4:e07486.  [Content Brief]

  [2]. Seo SK, et al. Blocking 4-1BB/4-1BB ligand interactions prevents herpetic stromal keratitis. J Immunol. 2003 Jul 15;171(2):576-83.  [Content Brief]

  [3]. Cho HR, et al. Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival. Transpl Int. 2004 Aug;17(7):351-61.  [Content Brief]

  [4]. Miki H, et al. 4-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis. J Immunol. 2020 Apr 1;204(7):1892-1903.  [Content Brief]

  [5]. Cho E, et al. 4-1BB-4-1BBL cis-interaction contributes to the survival of self-reactive CD8+ T cell. Cell Mol Immunol. 2023 Sep;20(9):1077-1080.  [Content Brief]