2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Anti-infection
  3. Reactive Oxygen Species (ROS) Fungal Bacterial
  4. Camalexin

Camalexin is a phytoalexin isolated from Camelina sativa (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production.

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Camalexin

Camalexin Chemical Structure

CAS No. : 135531-86-1

Size Prix Stock Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
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200 mg   Obtenir un devis  

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Based on 3 publication(s) in Google Scholar

Other Forms of Camalexin:

Camalexin Related Antibodies

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Description

Camalexin is a phytoalexin isolated from Camelina sativa (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production[1][2][3].

IC50 & Target

Reactive oxygen species (ROS)[1][2]
In Vitro

Camalexin shows antiproliferative activity against a human breast cancer cell line[2].
For the oomycetes Phytophthora and Pythium Nep1-like proteins (necrosis and ethylene-inducing peptide 1-like proteins) are the initial triggers of Camalexin synthesis and formation of reactive oxygen species (ROS). ROS appear to be of general relevance for Camalexin formation. Chemical induction of ROS, such as by application of acifluorfen, coincided with Camalexin synthesis. In a screen for enhanced susceptibility to Alternaria brassicicola the esa1 mutant is identified, which shows delayed Camalexin induction. Particularly in response to ROS inducing agents reduced Camalexin levels are synthesized. This crucial role for ESA1 is confirmed by the inability of esa1 mutants to synthesize Camalexin in response to Leptosphaeria maculans. An additional mutant that exhibits greatly reduced Camalexin accumulation is ups1, which is isolated on the basis of diminished expression of a tryptophan biosynthetic enzyme[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Camalexin Related Antibodies
Masse moléculaire

200.26

Formule

C11H8N2S
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

C12=C(C=CC=C2)NC=C1C3=NC=CS3
Structure Classification
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

DMSO : 175 mg/mL (873.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9935 mL 24.9675 mL 49.9351 mL
5 mM 0.9987 mL 4.9935 mL 9.9870 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Pureté et documentation

Purity: 99.70%

SDS (393 KB)

COA (255 KB) HNMR (241 KB) LCMS (90 KB)

Instruction de manipulation (2659 KB)
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9935 mL 24.9675 mL 49.9351 mL 124.8377 mL
5 mM 0.9987 mL 4.9935 mL 9.9870 mL 24.9675 mL
10 mM 0.4994 mL 2.4968 mL 4.9935 mL 12.4838 mL
15 mM 0.3329 mL 1.6645 mL 3.3290 mL 8.3225 mL
20 mM 0.2497 mL 1.2484 mL 2.4968 mL 6.2419 mL
25 mM 0.1997 mL 0.9987 mL 1.9974 mL 4.9935 mL
30 mM 0.1665 mL 0.8323 mL 1.6645 mL 4.1613 mL
40 mM 0.1248 mL 0.6242 mL 1.2484 mL 3.1209 mL
50 mM 0.0999 mL 0.4994 mL 0.9987 mL 2.4968 mL
60 mM 0.0832 mL 0.4161 mL 0.8323 mL 2.0806 mL
80 mM 0.0624 mL 0.3121 mL 0.6242 mL 1.5605 mL
100 mM 0.0499 mL 0.2497 mL 0.4994 mL 1.2484 mL
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Camalexin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Camalexin135531-86-1Reactive Oxygen Species (ROS)FungalBacterialPhytoalexinantifungalcruciferousantibacterialantiproliferativeanticancerROSInhibitorinhibitorinhibit

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SAFETY DATA SHEET (SDS)

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