Cannabidiorcol  (Synonyms: O-1821; CBD-C1)

Cannabidiorcol (CBDO, CBD-C1, O-1821) is related to cannabidiol, with the pentyl side chain shortened to a methyl group. Cannabidiorcol has low affinity for cannabinoid receptors (CBs) and is an agonist of the transient receptor potential channel (TRP channel), through which it produces antiinflammatory effects, but can also promote tumorigenesis at high concentrations^[1][2].

258.36

C₁₇H₂₂O₂

35482-50-9

Liquid

OC1=C([C@H]2[C@@H](CCC(C)=C2)C(C)=C)C(O)=CC(C)=C1

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Teresina Laragione, et al. Combination therapy of a TRPV2 agonist with a TNF inhibitor achieves sustained suppression of disease severity and reduced joint damage. Clin Exp Immunol. 2023 Mar; 211(3): 233–238.

  [2]. Rongqi Huang, et al. Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma. Br J Cancer. 2022 Nov 1; 127(8): 1424–1439.