2. Others Cell Cycle/DNA Damage Apoptosis
  3. Biochemical Assay Reagents Topoisomerase DNA/RNA Synthesis Apoptosis Necroptosis
  4. Cholesterol hemisuccinate Tris salt

Cholesterol hemisuccinate Tris salt  (Synonyms: Cholesterol hydrogen succinate Tris salt; CHS-Tris)

製品番号: HY-W010800A 純度: 99.98%
COA 取扱説明書 Technical Support

Cholesterol hemisuccinate (Cholesterol hydrogen succinate) Tris salt is a compound with hepatoprotective and anticancer activity. Cholesterol hemisuccinate Tris salt inhibits Acetaminophen (AAP) (HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesterol hemisuccinate Tris salt inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Cholesterol hemisuccinate Tris salt inhibits tumor growth. Cholesterol hemisuccinate Tris salt can be used for buffer preparation.

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Cholesterol hemisuccinate Tris salt

Cholesterol hemisuccinate Tris salt 構造式

CAS 番号 : 102601-49-0

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Solid
10 mg $25 在庫あり
25 mg $50 在庫あり
50 mg $75 在庫あり
100 mg $120 在庫あり
250 mg $180 在庫あり
500 mg $250 在庫あり
1 g $350 在庫あり
5 g   お問い合わせ  
10 g   お問い合わせ  

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Other Forms of Cholesterol hemisuccinate Tris salt:

Cholesterol hemisuccinate Tris salt 関連抗体

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製品説明

Cholesterol hemisuccinate (Cholesterol hydrogen succinate) Tris salt is a compound with hepatoprotective and anticancer activity. Cholesterol hemisuccinate Tris salt inhibits Acetaminophen (AAP) (HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesterol hemisuccinate Tris salt inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Cholesterol hemisuccinate Tris salt inhibits tumor growth. Cholesterol hemisuccinate Tris salt can be used for buffer preparation[1][2][3][4].

IC50 & Target

DNA Polymerase

 

体外実験

Cholesterol hemisuccinate Tris salt is an amphiphilic molecule that can be used for solubilization buffer preparation for glucan synthase assay[3].
Cholesterol hemisuccinate Tris salt can be used for buffer preparation for immunoprecipitation[4].
Cholesterol hemisuccinate Tris salt can be used as a membrane stabilizer[5].
Cholesterol hemisuccinate Tris salt can be used for drug delivery[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cholesterol hemisuccinate Tris salt 関連抗体
分子量

607.86

分子式

C35H61NO7
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

OCC(CO)(N)CO.C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OC(CCC(O)=O)=O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : 18.75 mg/mL (30.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6451 mL 8.2256 mL 16.4512 mL
5 mM 0.3290 mL 1.6451 mL 3.2902 mL
10 mM 0.1645 mL 0.8226 mL 1.6451 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 1.88 mg/mL (3.09 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.88 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (18.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.98%

COA (249 KB) HNMR (286 KB) RP-HPLC (234 KB) LCMS (81 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6451 mL 8.2256 mL 16.4512 mL 41.1279 mL
5 mM 0.3290 mL 1.6451 mL 3.2902 mL 8.2256 mL
10 mM 0.1645 mL 0.8226 mL 1.6451 mL 4.1128 mL
15 mM 0.1097 mL 0.5484 mL 1.0967 mL 2.7419 mL
20 mM 0.0823 mL 0.4113 mL 0.8226 mL 2.0564 mL
25 mM 0.0658 mL 0.3290 mL 0.6580 mL 1.6451 mL
30 mM 0.0548 mL 0.2742 mL 0.5484 mL 1.3709 mL
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Cholesterol hemisuccinate Tris salt Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cholesterol hemisuccinate102601-49-0Cholesterol hydrogen succinate CHS-TrisBiochemical Assay ReagentsTopoisomeraseDNA/RNA SynthesisApoptosisNecroptosisInhibitorinhibitorinhibit

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製品名:
Cholesterol hemisuccinate Tris salt
製品番号:
HY-W010800A
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