2. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage
  3. Tyrosinase Sirtuin
  4. Decapeptide-12

Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

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Decapeptide-12

Decapeptide-12 構造式

CAS 番号 : 137665-91-9

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10 mg $35 在庫あり
25 mg $65 在庫あり
50 mg $110 在庫あり
100 mg $180 在庫あり
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Decapeptide-12 関連抗体

Top Publications Citing Use of Products

Sirtuin アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7 SIRT4

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  • 純度とドキュメンテーション

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製品説明

Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation [1][2][3].

IC50 & Target

IC50: 40 µM (Tyrosinase)[1], Kd: 61.1 μM (Tyrosinase)[2].
体外実験

Decapeptide-12 (P4, 0.01-10 mΜ) dose-dependently inhibits mushroom tyrosinase with an IC50 value of 40 μM, and inhibits human tyrosinase by 25-35% at 100 μM[1].
Decapeptide-12 (100 μM, 7 days) leads to 43% reduction in melanin content in melanocytes with no effect on cell proliferation[1].
Decapeptide-12 (peptide P4, 0-400 μM) inhibits the monophenolase reaction with an IC50 value of 123 μM[2].
Decapeptide-12 interact with tyrosinase with a Kd value of 61.1 μM[2].
Decapeptide-12 (100 μM, 72 h) increases transcription of SIRT1, SIRT3, SIRT6, and SIRT7 with reduced cytotoxicity in human neonatal keratinocyte progenitors[3].
Decapeptide-12 (0-1 mM, 72 h) reduces Phytohemagglutinin (PHA)-stimulated PBMC cells proliferation[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Decapeptide-12 関連抗体

Cell Proliferation Assay[3]

Cell Line: Phytohemagglutinin (PHA)-stimulated PBMC cells
Concentration: 0, 0.025, 0.05, 0.1, 0.3, 1 mM
Incubation Time: 72 h
Result: Reduced cell proliferation by 28% at 0.05 mM and 54% at 0.1 mM.

RT-PCR[3]

Cell Line: Human neonatal keratinocyte progenitors
Concentration: 3, 10, 30, 50, 100, 300, 500, 1000 μM
Incubation Time: 72 h
Result: Increased transcription of SIRT1 by 141% relative to untreated cells, increased SIRT3, SIRT6 and SIRT7 by 121%, 147% and 95%, respectively.
分子量

1395.52

分子式

KS3WY3
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence Shortening

YRSRKYSSWY
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : ≥ 100 mg/mL (71.66 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7166 mL 3.5829 mL 7.1658 mL
5 mM 0.1433 mL 0.7166 mL 1.4332 mL
10 mM 0.0717 mL 0.3583 mL 0.7166 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.7166 mL 3.5829 mL 7.1658 mL 17.9145 mL
5 mM 0.1433 mL 0.7166 mL 1.4332 mL 3.5829 mL
10 mM 0.0717 mL 0.3583 mL 0.7166 mL 1.7914 mL
15 mM 0.0478 mL 0.2389 mL 0.4777 mL 1.1943 mL
20 mM 0.0358 mL 0.1791 mL 0.3583 mL 0.8957 mL
25 mM 0.0287 mL 0.1433 mL 0.2866 mL 0.7166 mL
30 mM 0.0239 mL 0.1194 mL 0.2389 mL 0.5971 mL
40 mM 0.0179 mL 0.0896 mL 0.1791 mL 0.4479 mL
50 mM 0.0143 mL 0.0717 mL 0.1433 mL 0.3583 mL
60 mM 0.0119 mL 0.0597 mL 0.1194 mL 0.2986 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Decapeptide-12 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Decapeptide-12137665-91-9Decapeptide12Decapeptide 12TyrosinaseSirtuinMelanocytesmelaninmelanogenesismushroom tyrosinasemonophenolaseoligopeptideanti-senescenceanti-aginganti-inflammationInhibitorinhibitorinhibit

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製品名:
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製品番号:
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