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  4. DL-alpha-Tocopherol

DL-α-トコフェロール?  (Synonyms: DL-alpha-Tocopherol; DL-α-Tocopherol)

製品番号: HY-W020044 純度: 99.57%
COA 取扱説明書 Technical Support

DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB.

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CAS 番号 : 10191-41-0

容量 価格（税別） 在庫状況 数量
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 38 在庫あり
Solution
10 mM * 1 mL in DMSO USD 38 在庫あり
Liquid
100 mg $35 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 7 publication(s) in Google Scholar

Other Forms of DL-alpha-Tocopherol:

DL-α-トコフェロール? 関連抗体

Top Publications Citing Use of Products

    DL-alpha-Tocopherol purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Jul;15(7):3788-3804.

    DL-alpha-Tocopherol (VE; 20 μM; 24 h) demonstrated a significant attenuation of cytotoxicity in the HIFU, NP + H, and NP-PF-H groups in 4T1 cells.

    DL-alpha-Tocopherol purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Feb 5;26(3):1334.  [Abstract]

    DL-alpha-Tocopherol (Vit E; 1-100 μM; 1 h and 30 min) combined with Curc and Vit C, showed Anti-Oxidant Effects in RBCs.

    DL-alpha-Tocopherol purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847.  [Abstract]

    HIPK2 expression is upregulated by treatments with 5 μM Resveratrol, 30 μM Aspirin, 10 μM DL-alpha-Tocopherol (vitamin E), and 15 μM Ursolic acid for another 16 h after the LPS treatment, as analysed by western blotting.

    DL-alpha-Tocopherol purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847.  [Abstract]

    HIPK2 expression was upregulated by treatments with 5 μM resveratrol, 30 μM aspirin, 10 μM DL-alpha-Tocopherol (vitamin E), and 15 μM ursolic acid for another 16 h after the LPS treatment, as analysed by Q-PCR.

    DL-alpha-Tocopherol purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847.  [Abstract]

    DL-alpha-Tocopherol (vitamin E; 10 μM) activated the promoter of the HIPK2 gene and by maintaining the stability of the 3′-UTR.

    DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB[1].

    Cellular Effect
    Cell Line Type Value Description References
    CHO EC50
    > 100 μM
    Compound: 10b
    Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as increase in amyloid beta 38 generation after 24 hrs by ELISA
    Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as increase in amyloid beta 38 generation after 24 hrs by ELISA
    		[PMID: 23707256]
    CHO IC50
    > 100 μM
    Compound: 10b
    Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 40 generation after 24 hrs by ELISA
    Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 40 generation after 24 hrs by ELISA
    		[PMID: 23707256]
    CHO IC50
    > 100 μM
    Compound: 10b
    Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 42 generation after 24 hrs by ELISA
    Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 42 generation after 24 hrs by ELISA
    		[PMID: 23707256]
    体外実験

    DL-alpha-Tocopherol (0.1-1 mM, 0-12 days) inhibits the proliferation of cancer cell OCIM-1, HEL and MCF-7, inhibits the DNA synthesis and induces apoptosis[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    DL-α-トコフェロール? 関連抗体

    Cell Proliferation Assay[3]

    Cell Line: OCIM-1, HEL and MCF-7
    Concentration: 0.1-1 mM
    Incubation Time: 0-12 days
    Result: Inhibited the proliferation.
    体内実験

    DL-alpha-Tocopherol (100 mg/kg, iv, single dose) inhibit iron-induced lipid peroxidation in amygdala, limits brain injury response in Sprague-Dawley rats models[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Sprague-Dawley rats models[2]
    Dosage: 100 mg/kg
    Administration: iv, single dose
    Result: Inhibited iron-induced lipid peroxidation in amygdala.
    分子量

    430.71

    分子式

    C29H50O2
    CAS 番号
    Appearance

    Liquid (Density: 0.950  g/cm3  )

    Color

    Light yellow to brown

    SMILES

    CC1=C2C(CCC(CCCC(C)CCCC(C)CCCC(C)C)(C)O2)=C(C)C(O)=C1C
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    Ethanol : ≥ 100 mg/mL (232.17 mM)

    DMSO : 20 mg/mL (46.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3217 mL 11.6087 mL 23.2175 mL
    5 mM 0.4643 mL 2.3217 mL 4.6435 mL
    10 mM 0.2322 mL 1.1609 mL 2.3217 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (5.80 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: 2.5 mg/mL (5.80 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.57%

    COA (241 KB) HNMR (262 KB) RP-HPLC (221 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / Ethanol 1 mM 2.3217 mL 11.6087 mL 23.2175 mL 58.0437 mL
    5 mM 0.4643 mL 2.3217 mL 4.6435 mL 11.6087 mL
    10 mM 0.2322 mL 1.1609 mL 2.3217 mL 5.8044 mL
    15 mM 0.1548 mL 0.7739 mL 1.5478 mL 3.8696 mL
    20 mM 0.1161 mL 0.5804 mL 1.1609 mL 2.9022 mL
    25 mM 0.0929 mL 0.4643 mL 0.9287 mL 2.3217 mL
    30 mM 0.0774 mL 0.3870 mL 0.7739 mL 1.9348 mL
    40 mM 0.0580 mL 0.2902 mL 0.5804 mL 1.4511 mL
    Ethanol 50 mM 0.0464 mL 0.2322 mL 0.4643 mL 1.1609 mL
    60 mM 0.0387 mL 0.1935 mL 0.3870 mL 0.9674 mL
    80 mM 0.0290 mL 0.1451 mL 0.2902 mL 0.7255 mL
    100 mM 0.0232 mL 0.1161 mL 0.2322 mL 0.5804 mL
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    DL-alpha-Tocopherol Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    DL-alpha-Tocopherol10191-41-0DL-α-TocopherolFerroptosisDNA/RNA SynthesisEnvironmental PollutantsApoptosisEnvironmental ContaminantsInhibitorinhibitorinhibit

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    製品名:
    DL-alpha-Tocopherol
    製品番号:
    HY-W020044
    数量:
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