DL-AP5 (Synonyms: 2-APV; DL-2-Amino-5-phosphonovaleric acid)

Name: DL-AP5
Brand: MedChemExpress
SKU: HY-100714
Rating: 5.0 (3 reviews)

Cat. No.: HY-100714 Purity: 99.70%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No. : 76326-31-3

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 3 publication(s) in Google Scholar

Other Forms of DL-AP5:

D-AP5 In-stock
DL-AP5 sodium In-stock
L-AP5 견적 받기
DL-AP5 lithium 견적 받기
DL-AP5 (Standard) 견적 받기

3 Publications Citing Use of MCE DL-AP5

In Vivo Efficacy Study

Bio/Physico-chemical Assay

: DL-AP5 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.; DL-AP5 (50 μM) abolished the training effect so that trained and untrained trajectories overlapped in the CNS-3D organoids.

: DL-AP5 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.; DL-AP5 (50 μM) suppressed activity-dependent neuronal recruitment and blocked stimulation-driven LTP in CNS-3D organoid networks, as the number of unique neurons remained low under NMDA receptor blockade.

: DL-AP5 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.; DL-AP5 (200 μM). Heat map of GSVA scores across 15 GO terms associated with learning, memory, LTP, and synaptic plasticity.

: DL-AP5 purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Oct 28:136767. [Abstract]; Effects of a single injection of DL-AP5 (5 μg; i.t.) on the tactile and pressure withdrawal thresholds and heat withdrawal latency within 2 h in KD-Setd2 and NC rats.

: DL-AP5 purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Oct 28:136767. [Abstract]; The mean changes of baseline values and the DL-AP5 (50 μM) effect on the frequency and amplitude of mEPSCs in spinal dorsal horn neurons of Setd2^fl/fl and Setd2-cKO mice.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina^[1]^[2]^[3].

IC₅₀ & Target

NMDA Receptor

Cellular Effect

Cell Line	Type	Value	Description	References
Pyramidal neuron	IC₅₀	0.31 μM Compound: L-AP5	sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4,L-AP5 and L-AP6 after exposure to quisqualic acid sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4,L-AP5 and L-AP6 after exposure to quisqualic acid	[PMID: 7966155]
Pyramidal neuron	IC₅₀	2.2 μM Compound: L-AP5	sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 after reversal with L-alpha-AA sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 after reversal with L-alpha-AA	[PMID: 7966155]
Pyramidal neuron	IC₅₀	2.3 μM Compound: L-AP5	sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 before exposure to quisqualic acid sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 before exposure to quisqualic acid	[PMID: 7966155]

In Vitro

DL-AP5 (100 μM) partially prevents glutamate-induced increase in Arc/Arg3.1 protein levels^[5].
DL-AP5 decreases the NMDA-induced Arc/Arg3.1 upregulation^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA^[3].
DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption^[4].
DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (180-230 g)^[3]
Dosage:	1, 3.2 and 10 μg/rat
Administration:	Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once
Result:	Significantly decreased the effect of NMDA (10^-2 μg/rat, intra-CA1) with significant interaction.

Animal Model:	Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)^[4]
Dosage:	0, 2.5, 5, and 10 nmol; in a volume of 10 μL
Administration:	Intracerebroventricular injection
Result:	Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses.

Animal Model:	Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)^[4]
Dosage:	5 nmol
Administration:	Intracerebroventricular injection, followed by ghrelin (0.6 nmol)
Result:	Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin.

분자량

197.13

화학식

C₅H₁₂NO₅P

CAS No.

76326-31-3

Appearance

Solid

Color

White to off-white

SMILES

NC(CCCP(O)(O)=O)C(O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

H₂O : 33.33 mg/mL (169.08 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.0728 mL	25.3640 mL	50.7279 mL
5 mM	1.0146 mL	5.0728 mL	10.1456 mL
10 mM	0.5073 mL	2.5364 mL	5.0728 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (253.64 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.70%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (244 KB) HNMR (247 KB) CNMR (311 KB) RP-HPLC (237 KB) MS (81 KB)

Handling Instructions (2659 KB)

References

[1]. Murray CW, et al. Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain. 1991;44(2):179-185. [Content Brief]

[2]. Massey SC, et al. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J Neurophysiol. 1990;63(1):16-30. [Content Brief]

[3]. Jafari-Sabet M. NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats. Behav Brain Res. 2006 Apr 25;169(1):120-7. [Content Brief]

[4]. Taati M, et al. The effects of DL-AP5 and glutamate on ghrelin-induced feeding behavior in 3-h food-deprived broiler cockerels. J Physiol Biochem. 2011 Jun;67(2):217-23. [Content Brief]

[5]. Chen T, et al. Glutamate-induced rapid induction of Arc/Arg3.1 requires NMDA receptor-mediated phosphorylation of ERK and CREB. Neurosci Lett. 2017 Nov 20;661:23-28. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.0728 mL	25.3640 mL	50.7279 mL	126.8199 mL
	5 mM	1.0146 mL	5.0728 mL	10.1456 mL	25.3640 mL
	10 mM	0.5073 mL	2.5364 mL	5.0728 mL	12.6820 mL
	15 mM	0.3382 mL	1.6909 mL	3.3819 mL	8.4547 mL
	20 mM	0.2536 mL	1.2682 mL	2.5364 mL	6.3410 mL
	25 mM	0.2029 mL	1.0146 mL	2.0291 mL	5.0728 mL
	30 mM	0.1691 mL	0.8455 mL	1.6909 mL	4.2273 mL
	40 mM	0.1268 mL	0.6341 mL	1.2682 mL	3.1705 mL
	50 mM	0.1015 mL	0.5073 mL	1.0146 mL	2.5364 mL
	60 mM	0.0845 mL	0.4227 mL	0.8455 mL	2.1137 mL
	80 mM	0.0634 mL	0.3170 mL	0.6341 mL	1.5852 mL
	100 mM	0.0507 mL	0.2536 mL	0.5073 mL	1.2682 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

DL-AP5 Related Classifications

Neurological Disease Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-AP576326-31-32-APV DL-2-Amino-5-phosphonovaleric acidiGluRIonotropic glutamate receptorsAntinociceptive activityTonic painGanglion cellsRetinaArc/Arg3.1Glutamate receptorInhibitorinhibitorinhibit

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DL-AP5 (Synonyms: 2-APV; DL-2-Amino-5-phosphonovaleric acid)

고객리뷰

Other Forms of DL-AP5:

DL-AP5 Related Antibodies

3 Publications Citing Use of MCE DL-AP5

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All iGluR Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

DL-AP5 Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

DL-AP5 Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

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