Dupilumab (Synonyms: REGN-668; SAR-231893)

Name: Dupilumab
Brand: MedChemExpress
SKU: HY-P9926
Rating: 5.0 (6 reviews)

Art. -Nr.: HY-P9926 Reinheit: ≥99.2%: Data Sheet
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SDS

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Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr. : 1190264-60-8

Größe	Verfügbarkeit	Menge
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
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500 mg	Angebot einholen

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Based on 6 publication(s) in Google Scholar

Dupilumab Spezialitätsempfehlungen:

6 Publications Citing Use of MCE Dupilumab

ELISA

RT-PCR

Cell Imaging/Staining

Flow Cytometry

: Dupilumab purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 16;19(36):32361-32373. [Abstract]; Dupilumab (5 μg/mL, 48 h). Cytokine concentrations measured in culture supernatants following drug treatments.

: Dupilumab purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 16;19(36):32361-32373. [Abstract]; Representative images of spheroids subjected to microfluidic deformation analysis, comparing untreated control, antifibrotic drug NTD, and anti-interleukin drugs TCZ, STX, DUP (Dupilumab; 5 μg/L; 48 h), and TRA.

: Dupilumab purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 16;19(36):32361-32373. [Abstract]; Confocal fluorescence images showing the expression of collagen-1 and α-SMA in spheroids treated with NTD, TCZ, STX, DUP (Dupilumab, 5 μg/L, 48 h), and TRA.

: Dupilumab purchased from MedChemExpress. Usage Cited in: Allergy. 2025 Oct 22. [Abstract]; Comparison of mRNA levels for SCGB1A1, FOXJ1, and MUC5AC in untreated, IL-13, AS1517499, and Dupilumab (10 μM, 6 h)-treated HNECs using RT-qPCR.

: Dupilumab purchased from MedChemExpress. Usage Cited in: Allergy. 2025 Oct 22. [Abstract]; Dupilumab (10 μM, 6 h). Flow cytometry analysis of changes in SCGB1A1⁺βIVtubulin and SCGB1A1⁺MUC5AC⁺ clusters across treatment groups.

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Interleukin Related Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

Biologische Aktivität
Reinheit & Dokumentation
Verweise
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Beschreibung

Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis^[1].

Isotype

Human IgG4 kappa

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target^[1]

IL-2

IL-4

IL-13

In Vitro

Dupilumab suppressed mRNA expressions of genes related to activation of T cells, DCs, eosinophils, inflammatory pathways, and TH2-inducing chemokines in skin lesions. No significant reduction in IL-17A or IL-22 levels is detected, but large reductions in expression of IL-17–related genes, such as elafin (PI3), IL23p19/IL23A, and S100A8 and trends for suppression (CXCL1 and S100A7) are found with 300 mg of Dupilumab^[1].
Major suppressions of hyperplasia-related genes (eg, K16) and reductions in expression of S100A genes are evident with 300 mg of Dupilumab by using microarrays and qRT-PCR. The changes in other critical epidermal alterations in severe atopic dermatitis (AD) skin are also measured, including significant increases in claudin and lipid product levels with 300 mg of Dupilumab. A trend of dose-dependent increases in expression of differentiation genes (LOR and FLG) is observed after adjusting for suppression of epidermal hyperplasia, as demonstrated by K16 reductions with Dupilumab^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Klinische Studie

Gene ID

3566 [NCBI]

Accession

P24394

Application

ELISA, FACS, Functional assay

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molekulargewicht

147 kDa

CAS. Nr.

1190264-60-8

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Dupilumab]

Formulation

Please refer to the lot-specific COA for specific buffer information.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Format

Human IgG4 kappa

Biological Activity

Flow cytometry analysis of Raji cells labelling IL-4Rα with Dupilumab at 100nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).

Reinheit & Dokumentation

Purity: ≥99.2%

Select Batch:

Data Sheet (260 KB) SDS (251 KB)

COA (231 KB)

Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Hamilton JD, et al. Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis. J Allergy Clin Immunol. 2014 Dec;134(6):1293-1300. [Content Brief]

Dupilumab Related Classifications

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dupilumab1190264-60-8REGN-668 SAR-231893REGN668REGN 668SAR231893SAR 231893SAR-231893Interleukin RelatedILInhibitorinhibitorinhibit

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Dupilumab (Synonyms: REGN-668; SAR-231893)

Kundenbewertung

Dupilumab Spezialitätsempfehlungen:

Dupilumab Related Antibodies

6 Publications Citing Use of MCE Dupilumab

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Interleukin Related Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

Dupilumab Related Antibodies

Dupilumab Related Classifications

Molaritätsrechner

Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

The dilution calculator equation

Keywords:

Ihre kürzlich angesehenen Produkte:

Kundenbewertung

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