2. Cytoskeleton
  3. Integrin
  4. Emvistegrast

Emvistegrast (GS-1427) is a quinolone derivative. Emvistegrast is also an inhibitor of α4β7 integrin. Emvistegrast can be used to investigate diseases mediated by α4β7 integrin, such as inflammatory bowel disease.

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Emvistegrast

Emvistegrast Estructura química

No. CAS : 2417352-91-9

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Other Forms of Emvistegrast:

Emvistegrast Related Antibodies

Top Publications Citing Use of Products

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Ver todas las isoformas
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Descripciòn

Emvistegrast (GS-1427) is a quinolone derivative. Emvistegrast is also an inhibitor of α4β7 integrin. Emvistegrast can be used to investigate diseases mediated by α4β7 integrin, such as inflammatory bowel disease[1][2].

IC50 & Target[1]

α4β7

 

In Vivo

Emvistegrast (Compound 488) is applicable to inflammatory bowel disease research[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular

708.66

Fòrmula

C35H32F4N6O6
No. CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

CCOC([C@H](CC1=CC=C(N2C(N(C3=C(C2=O)C=CN=C3)C)=O)C4=C1C=CC=N4)NC(C5=C(C=C(C=C5F)N6[C@H](COCC6)C(F)(F)F)C)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Pureza y Documentación
Referencias
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Emvistegrast Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emvistegrast2417352-91-9GS-1427GS1427GS 1427Integrinquinolone derivativeα4β7 Integrin Inhibitorinflammatory bowel diseaseInhibitorinhibitorinhibit

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Nombre del producto:
Emvistegrast
Cat. No.:
HY-177080
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