2. Epigenetics TGF-beta/Smad Autophagy Apoptosis
  3. PKC Autophagy Apoptosis
  4. Enzastaurin hydrochloride

Enzastaurin hydrochloride  (Synonyms: LY317615 hydrochloride)

Cat. No.: HY-10539B
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Enzastaurin (LY317615) hydrochloride is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε.

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No. CAS : 359017-79-1

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Top Publications Citing Use of Products

    Enzastaurin hydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2022 Mar;41(11):1536-1549.  [Abstract]

    Enzastaurin (10 μM). VCaP cells cultured in RPMI1640 supplemented with 5% CSS for 48 h were treated as indicated for 72 h and then immunoblotted for AR and AR-V7.

    Enzastaurin hydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2022 Mar;41(11):1536-1549.  [Abstract]

    22RV1 cells express AR-V7 protein and contain LBD mutation H875Y. 22RV1 (2000 cells/well) cells were cultured in RPMI1640 supplemented with 5% CSS for 48 h in 96 well plates. In the presence of 0.1 nM DHT, cells were treated with a nine-point threefold dilution series of MDV (beginning at 30 μM) in the presence or absence of a constant concentration of Enzastaurin for five days.

    Enzastaurin hydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2022 Mar;41(11):1536-1549.  [Abstract]

    Enzastaurin (10 μM). VCaP cells were cultured in RPMI 1640 medium supplemented with 5% CSS for 48 h, pretreated with DHT for 24 h, then washed off the medium, and treated again as shown for 24 h. Finally, AR mRNA transcription levels were analyzed by RT-qPCR.

    Enzastaurin hydrochloride purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2022 Oct 26;10(5):e0105622.  [Abstract]

    IC50 and CC50 values ​​of Enzastaurin in BHK-21 cells.

    Enzastaurin hydrochloride purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2022 Oct 26;10(5):e0105622.  [Abstract]

    A549-ACE2 cells were treated with DMSO, Go 6983, Bisindolylmaleimide I, or Enzastaurin for 1 h, followed by virus infection. At 24 h p.i., cells or supernatants were harvested for an immunofluorescence assay.

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    PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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    Descripciòn

    Enzastaurin (LY317615) hydrochloride is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε[1][2][3].

    Peso molecular

    552.07

    Fòrmula

    C32H30ClN5O2
    No. CAS
    SMILES

    O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3C4=CN(C5CCN(CC6=NC=CC=C6)CC5)C7=C4C=CC=C7)NC3=O.Cl
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    Room temperature in continental US; may vary elsewhere.
    Almacenamiento

    Please store the product under the recommended conditions in the Certificate of Analysis.
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Enzastaurin359017-79-1LY317615LY 317615LY-317615PKCAutophagyApoptosisProtein kinase CInhibitorinhibitorinhibit

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    Nombre del producto:
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