2. Anti-infection
  3. Bacterial Antibiotic
  4. Fleroxacin

フレロキサシン  (Synonyms: Fleroxacin; RO 23-6240; AM-833)

製品番号: HY-B0414 純度: 99.90%
COA 取扱説明書 Technical Support

Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone.

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Fleroxacin

フレロキサシン 構造式

CAS 番号 : 79660-72-3

容量 価格（税別） 在庫状況 数量
500 mg $30 在庫あり
1 g $50 在庫あり
5 g $120 在庫あり
10 g $180 在庫あり
25 g $344 在庫あり
50 g $517 在庫あり
100 g $750 在庫あり
> 100 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Fleroxacin:

フレロキサシン 関連抗体

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Antibiotic アイソフォーム固有の製品をすべて表示:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone.

IC50 & Target

Quinolone

 

Cellular Effect
Cell Line Type Value Description References
V79 IC50
> 500 μg/mL
Compound: 5 Fleroxacin
Mammalian cell cytotoxicity test in chinese hamster V79 cells (clonogenic cytotoxicity)
Mammalian cell cytotoxicity test in chinese hamster V79 cells (clonogenic cytotoxicity)
[PMID: 1469702]
体内実験

Fleroxacin (Ro 23-6240) is a new trifluorinated quinolone exhibiting high activity against a broad spectrum of gram-negative and gram-positive bacteria. Fleroxacin is characterized pharmacokinetically by a long elimination half-life (9 to 10 h) and high concentrations in plasma (e.g., maximum concentration of 2.3 micrograms/ml after an oral dose of 200 mg)[1]. Fleroxacin (Ro 23-6240) is effective against Haemophilus ducreyi in vitro. Fleroxacin (Ro 23-6240), 200 or 400 mg as a single oral dose, is efficacious therapy for microbiologically proven chancroid in patients who do not have concurrent HIV-1 infection. Among HIV-1-infected men, a single dose of 200 or 400 mg of fleroxacin is inadequate therapy for chancroid[2][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

369.34

分子式

C17H18F3N3O3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(CCF)C2=C(C=C(F)C(N3CCN(C)CC3)=C2F)C1=O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

H2O : 33.33 mg/mL (90.24 mM; ultrasonic and adjust pH to 11 with NaOH)

0.1 M NaOH : 9.17 mg/mL (24.83 mM; ultrasonic and adjust pH to 12 with NaOH)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7075 mL 13.5377 mL 27.0753 mL
5 mM 0.5415 mL 2.7075 mL 5.4151 mL
10 mM 0.2708 mL 1.3538 mL 2.7075 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.90%

COA (247 KB) LCMS (256 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
0.1 M NaOH / H2O 1 mM 2.7075 mL 13.5377 mL 27.0753 mL 67.6883 mL
5 mM 0.5415 mL 2.7075 mL 5.4151 mL 13.5377 mL
10 mM 0.2708 mL 1.3538 mL 2.7075 mL 6.7688 mL
15 mM 0.1805 mL 0.9025 mL 1.8050 mL 4.5126 mL
20 mM 0.1354 mL 0.6769 mL 1.3538 mL 3.3844 mL
H2O 25 mM 0.1083 mL 0.5415 mL 1.0830 mL 2.7075 mL
30 mM 0.0903 mL 0.4513 mL 0.9025 mL 2.2563 mL
40 mM 0.0677 mL 0.3384 mL 0.6769 mL 1.6922 mL
50 mM 0.0542 mL 0.2708 mL 0.5415 mL 1.3538 mL
60 mM 0.0451 mL 0.2256 mL 0.4513 mL 1.1281 mL
80 mM 0.0338 mL 0.1692 mL 0.3384 mL 0.8461 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Fleroxacin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fleroxacin79660-72-3RO 23-6240 AM-833AM833AM 833AM-833BacterialAntibioticInhibitorinhibitorinhibit

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製品名:
Fleroxacin
製品番号:
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