2. Anti-infection
  3. Bacterial Antibiotic
  4. Fosfomycin

Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Fosfomycin tromethamine) that retains the same biological activity.

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Fosfomycin

Fosfomycin 構造式

CAS 番号 : 23155-02-4

容量 在庫状況
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Other 在庫あり Forms of Fosfomycin:

Other Forms of Fosfomycin:

Fosfomycin 関連抗体

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製品説明

Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1][2].

Cellular Effect
Cell Line Type Value Description References
A-431 IC50
>=100 μM
Compound: Fosfomycin
Cytotoxicity against human A431 cells after 72 hrs by crystal violet staining method
Cytotoxicity against human A431 cells after 72 hrs by crystal violet staining method
[PMID: 23266177]
A-431 IC50
≥ 100 μM
Compound: Fosfomycin
Cytotoxicity against human A431 cells after 72 hrs by crystal violet staining method
Cytotoxicity against human A431 cells after 72 hrs by crystal violet staining method
[PMID: 23266177]
Calu-6 IC50
>=100 μM
Compound: Fosfomycin
Cytotoxicity against human Calu6 cells after 72 hrs by crystal violet staining method
Cytotoxicity against human Calu6 cells after 72 hrs by crystal violet staining method
[PMID: 23266177]
Calu-6 IC50
≥ 100 μM
Compound: Fosfomycin
Cytotoxicity against human Calu6 cells after 72 hrs by crystal violet staining method
Cytotoxicity against human Calu6 cells after 72 hrs by crystal violet staining method
[PMID: 23266177]
CAPAN-1 IC50
>=100 μM
Compound: Fosfomycin
Cytotoxicity against human Capan1 cells after 72 hrs by crystal violet staining method
Cytotoxicity against human Capan1 cells after 72 hrs by crystal violet staining method
[PMID: 23266177]
CAPAN-1 IC50
≥ 100 μM
Compound: Fosfomycin
Cytotoxicity against human Capan1 cells after 72 hrs by crystal violet staining method
Cytotoxicity against human Capan1 cells after 72 hrs by crystal violet staining method
[PMID: 23266177]
Ca-Ski IC50
>=100 μM
Compound: Fosfomycin
Cytotoxicity against human CaSki cells after 72 hrs by crystal violet staining method
Cytotoxicity against human CaSki cells after 72 hrs by crystal violet staining method
[PMID: 23266177]
Ca-Ski IC50
≥ 100 μM
Compound: Fosfomycin
Cytotoxicity against human CaSki cells after 72 hrs by crystal violet staining method
Cytotoxicity against human CaSki cells after 72 hrs by crystal violet staining method
[PMID: 23266177]
HaCaT IC50
>=100 μM
Compound: Fosfomycin
Cytotoxicity against human HaCaT cells after 72 hrs by crystal violet staining method
Cytotoxicity against human HaCaT cells after 72 hrs by crystal violet staining method
[PMID: 23266177]
HaCaT IC50
≥ 100 μM
Compound: Fosfomycin
Cytotoxicity against human HaCaT cells after 72 hrs by crystal violet staining method
Cytotoxicity against human HaCaT cells after 72 hrs by crystal violet staining method
[PMID: 23266177]
MeWo IC50
>=100 μM
Compound: Fosfomycin
Cytotoxicity against human MeWo cells after 72 hrs by crystal violet staining method
Cytotoxicity against human MeWo cells after 72 hrs by crystal violet staining method
[PMID: 23266177]
MeWo IC50
≥ 100 μM
Compound: Fosfomycin
Cytotoxicity against human MeWo cells after 72 hrs by crystal violet staining method
Cytotoxicity against human MeWo cells after 72 hrs by crystal violet staining method
[PMID: 23266177]
体内実験

Fosfomycin (80 mg/kg; i.v. or p.o.) displays the protective effect on the nephrotoxicity of double beckacin, and is not affected by different administration routes in rats[3].
Pharmacokinetic of Fosfomycin in Rats[4]

Dibekacin Dose (mg) Vdss (l/kg) β (min-1) T1/2 (min) Urinary recovery (%)
30 0.261 0.0244 28.4 85

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fischer 344 rats[3]
Dosage: 320 mg/kg
Administration: Intramuscular injection, 5 schedules: 1 h, 0.5 h earlier than dibekacin, concomitantly, 0.5 h later and 1 h later; 11 days
Result: Reduced polyuria, proteinuria, enzymes and cytosine caused by dibecacin (40 mg/kg), followed by the previous treatment.
Animal Model: Dehydrated Wistar rat with acute renal failure (8-week-old)[4]
Dosage: 120 mg/kg
Administration: Intravenous injection; once
Result: Recovered the exclusion rate of rats basically to normal, and improved the nephrotoxicity parameters.
Protects proximal tubular lysosomes from aminoglycosides by inhibiting myeloid formation and protecting the integrity of lysosomal membrane of rats treated with double bekacin.
分子量

138.06

分子式

C3H7O4P
CAS 番号
SMILES

C[C@@H]1O[C@@H]1P(O)(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Fosfomycin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fosfomycin23155-02-4MK-0955MK0955MK 0955BacterialAntibioticsepsispharmacokineticsafetymultidrug-resistantMDRextensively drug-resistantXDRpan-drug-resistantPDR,antimicrobial activityantibioticdibekacinnephrotoxicitydrug eliminationrenal lysosomedehydrated mouseInhibitorinhibitorinhibit

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製品名:
Fosfomycin
製品番号:
HY-B1075A
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