1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Fosfomycin tromethamine

Fosfomycin tromethamine (Synonyms: MK-0955 tromethamine)

Cat. No.: HY-B0609
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Fosfomycin (MK-0955) tromethamine is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin tromethamine shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria.

For research use only. We do not sell to patients.

Fosfomycin tromethamine Chemical Structure

Fosfomycin tromethamine Chemical Structure

CAS No. : 78964-85-9

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Description

Fosfomycin (MK-0955) tromethamine is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin tromethamine shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1][2].

In Vitro

Fosfomycin tromethamine is an epoxy antibacterial agent. Compared with other antibacterial agents, it acts by inhibiting the early process of cell wall synthesis[1].
Fosfomycin tromethamine has bactericidal activity against a variety of gram-negative and gram-positive pathogens, including broad-spectrum production β-Bacteria of lactamase and carbapenemase, and against S. aureus strains with an inhibition rate of 90%[1].
Fosfomycin tromethamine displays extensive tissue penetration, can be used to research of infections of the CNS, soft tissues, bone, lungs, and abscesses[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fosfomycin tromethamine (80 mg/kg; i.v.-i.v. or i.v.-p.o.) displays the protective effect on the nephrotoxicity of double beckacin, and is not affected by different administration routes in rats[3].
Pharmacokinetic of Fosfomycin Tromethamine in Rats[4]

Dibekacin Dose (mg) Vdss (l/kg) β (min-1) T1/2 (min) Urinary recovery (%)
30 0.261 0.0244 28.4 85

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fischer 344 rats[3]
Dosage: 320 mg/kg
Administration: Intramuscular injection, 5 schedules: 1 h, 0.5 h earlier than dibekacin, concomitantly, 0.5 h later and 1 h later; 11 days
Result: Reduced polyuria, proteinuria, enzymes and cytosine caused by dibecacin (40 mg/kg), followed by the previous treatment.
Animal Model: Dehydrated Wistar rat with acute renal failure (8-week-old)[4]
Dosage: 120 mg/kg
Administration: Intravenous injection; once
Result: Recovered the exclusion rate of rats basically to normal, and improved the nephrotoxicity parameters.
Protects proximal tubular lysosomes from aminoglycosides by inhibiting myeloid formation and protecting the integrity of lysosomal membrane of rats treated with double bekacin.
Clinical Trial
Molecular Weight

259.19

Formula

C7H18NO7P

CAS No.
SMILES

C[[email protected]@H]1O[[email protected]@H]1P(O)(O)=O.OCC(CO)(N)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Fosfomycin tromethamine
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