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  3. Fosfomycin calcium

Fosfomycin calcium  (Synonyms: MK-​0955 calcium)

Cat. No.: HY-B1075 Purity: ≥98.0%
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Fosfomycin (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin calcium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria.

For research use only. We do not sell to patients.

Fosfomycin calcium Chemical Structure

Fosfomycin calcium Chemical Structure

CAS No. : 26016-98-8

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Based on 4 publication(s) in Google Scholar

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Description

Fosfomycin (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin calcium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1][2].

In Vitro

Fosfomycin calcium is an epoxy antibacterial agent. Compared with other antibacterial agents, it acts by inhibiting the early process of cell wall synthesis[1].
Fosfomycin calcium has bactericidal activity against a variety of gram-negative and gram-positive pathogens, including broad-spectrum production β-Bacteria of lactamase and carbapenemase, and against S. aureus strains with an inhibition rate of 90%[1].
Fosfomycin calcium displays extensive tissue penetration, can be used to research of infections of the CNS, soft tissues, bone, lungs, and abscesses[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fosfomycin calcium (80 mg/kg; i.v.-i.v. or i.v.-p.o.) displays the protective effect on the nephrotoxicity of double beckacin, and is not affected by different administration routes[3].
Pharmacokinetic of Fosfomycin calcium in Rats[4]

Dibekacin Dose (mg) Vdss (l/kg) β (min-1) T1/2 (min) Urinary recovery (%)
30 0.261 0.0244 28.4 85

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fischer 344 rats[3]
Dosage: 320 mg/kg
Administration: Intramuscular injection, 5 schedules: 1 h, 0.5 h earlier than dibekacin, concomitantly, 0.5 h later and 1 h later; 11 days
Result: Reduced polyuria, proteinuria, enzymes and cytosine caused by dibecacin (40 mg/kg), followed by the previous treatment.
Animal Model: Dehydrated Wistar rat with acute renal failure (8-week-old)[4]
Dosage: 120 mg/kg
Administration: Intravenous injection; once
Result: Recovered the exclusion rate of rats basically to normal, and improved the nephrotoxicity parameters.
Protects proximal tubular lysosomes from aminoglycosides by inhibiting myeloid formation and protecting the integrity of lysosomal membrane of rats treated with double bekacin.
Clinical Trial
Molecular Weight

176.12

Formula

C3H5CaO4P

CAS No.
SMILES

C[[email protected]]1[[email protected]@H](P([O-])([O-])=O)O1.[Ca+2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (283.90 mM; ultrasonic and adjust pH to 2 with HCl)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6779 mL 28.3897 mL 56.7795 mL
5 mM 1.1356 mL 5.6779 mL 11.3559 mL
10 mM 0.5678 mL 2.8390 mL 5.6779 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: ≥98.0%

References
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Fosfomycin calcium
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HY-B1075
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