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517

" in MedChemExpress (MCE) Product Catalog:

40

Inhibitors & Agonists

4

Fluorescent Dyes

1

Biochemical Assay Reagents

5

Peptides

1

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1

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1

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1

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8

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10634
    AMG 517
    5+ Cited Publications

    		 TRP Channel Neurological Disease
    AMG 517 is a potent and selective vanilloid receptor-1 (TRPV1) antagonist with an IC50 of 0.5 nM.
    AMG 517
  • HY-157941
    ART0380

    		ATM/ATR Checkpoint Kinase (Chk) DNA/RNA Synthesis Cancer
    ART0380 is a potent, selective and orally active ATR kinase inhibitor. ART0380 potently inhibits human ATR-ATRIP complex with an IC50 of 51.7 nM. ART0380 binds the ATP pocket of the ATR-ATRIP complex, blocks ATR-dependent Chk1 serine 345 phosphorylation, and induces cell cycle disorder and DNA damage. ART0380 demonstrates potent and selective antitumor activity in preclinical models with varying types of ataxia-telangiectasia mutated (ATM) gene aberrancy. ART0380 can be used for the research of cancer, such as colorectal cancer and prostate cancer .
    ART0380
  • HY-156682
    JNT-517

    		Amino acid Transporter Metabolic Disease
    JNT-517 is an orally active, selective SLC6A19 allosteric inhibitor with an IC50 of 47 nM for human SLC6A19. JNT-517 can be used for the study of phenylketonuria (PKU) .
    JNT-517
  • HY-D1314
    FAM azide, 6-isomer

    6-FAM azide

    		 Fluorescent Dye Others
    FAM azide, 6-isomer (6-FAM azide) is a 6-carboxyfluorescein derivative with an azide functional group and coupling partner in copper-catalyzed azide-alkyne cycloaddition. FAM azide, 6-isomer participates in synthesis of fluorescently tagged disparlure enantiomers for pheromone-binding protein binding assays. FAM azide, 6-isomer is widely used for labeling oligonucleotides (Ex/Em = 493/517 nm) .
    FAM azide, 6-isomer
  • HY-P991204
    Anti-PSMA Antibody

    ARX517 antibody

    		 PSMA Cancer
    Anti-PSMA Antibody (ARX517 antibody) is a humanized IgG1 monoclonal antibody that targets PSMA. Anti-PSMA Antibody is the antibody part of the ADC molecule ARX517. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
    Anti-PSMA Antibody
  • HY-D0056
    5-Carboxyfluorescein diacetate N-succinimidyl ester
    5+ Cited Publications

    		 Fluorescent Dye Others
    5-Carboxyfluorescein diacetate N-succinimidyl ester is a cell permeable dye (Ex=492 nm, Em=517 nm). 5-Carboxyfluorescein diacetate N-succinimidyl ester can label cells by covalently binding to intracellular molecules. 5-Carboxyfluorescein diacetate N-succinimidyl ester is used to track lymphocyte migration and proliferation .
    5-Carboxyfluorescein diacetate N-succinimidyl ester
  • HY-13842
    BX517
    2 Publications Verification

    		 PDK-1 Cancer
    BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.
    BX517
  • HY-12927
    SX-517

    		CXCR Inflammation/Immunology
    SX-517 is a dual CXCR2/1 antagonist, containing boronic acid. SX-517 inhibits CXCL1-induced Ca 2+ flux (IC50=38 nM), and antagonizes CXCL8-induced [(35)S]GTPγS binding (IC50=60 nM) and ERK1/2 phosphorylation. SX-517 has significant ability for inflammation suppression, in both humanized polymorphonuclear (PMN) cells and in murine model .
    SX-517
  • HY-12747
    DC_517
    2 Publications Verification

    		 DNA Methyltransferase Cancer
    DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 μM and 0.91 μM, respectively.
    DC_517
  • HY-131008
    Fluorescein tyramide
    1 Publications Verification

    		 Fluorescent Dye Others
    Fluorescein tyramide is a green fluorescent reagent (λabs: 494 nm; λem: 517 nm). Fluorescein tyramide is widely used for tyramide signal amplification (TSA) with a low-abundance in IHC, ICC, in situ hybridization (FISH) and flow cytometry (FCM) applications .
    Fluorescein tyramide
  • HY-160005
    LMP517

    NSC 781517

    		 Topoisomerase DNA/RNA Synthesis Cancer
    LMP517 (NSC 781517) is a potent and non-camptothecin Topoisomerase I and II (TOP1 and TOP2) dual inhibitor. LMP517 can induce TOP1 and TOP2 cleavage complexes (TOP1ccs and TOP2ccs). LMP517 can induce cancer cells DNA damage and γH2AX production. LMP517 can be used for the research of cancer, such as small cell lung cancer .
    LMP517
  • HY-W009384
    1,4-Dioxacycloheptadecane-5,17-dione

    Ethylene brassylate

    		 Environmental Pollutants Biochemical Assay Reagents Others
    1,4-Dioxacycloheptadecane-5,17-dione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    1,4-Dioxacycloheptadecane-5,17-dione
  • HY-146814
    EBOV/MARV-IN-3

    		Filovirus Infection
    EBOV/MARV-IN-3 (compound 32) is a potent EBOV and MARV inhibitor with IC50 values of 0.5, 1.2 µM, respectively. EBOV/MARV-IN-3 binds to the hydrophobic pocket close to EBOV Y517. EBOV/MARV-IN-3 shows antiviral activity .
    EBOV/MARV-IN-3
  • HY-P2360
    G12

    Ras 5-17

    		 Ras Others
    G12 (Ras 5-17) is a wild-type Ras peptide consisted of amino acids 5-17 (KLVVVGAGGVGKS). G12 can be used as a control of mutant Ras peptides studies (such V12) .
    G12
  • HY-P1905
    [Gln8]-C517 (LH-RH), chicken

    		GnRH Receptor Endocrinology
    [Gln8]-C517 (LH-RH), chicken is an avian hypothalamic peptide, which stimulates release of gonadotropins from anterior pituitary, thus regulating reproductive functions.
    [Gln8]-C517 (LH-RH), chicken
  • HY-114575
    Cycloxydim

    BAS 517-02H

    		 Herbicide Acetyl-CoA Carboxylase Others
    Cycloxydim (BAS 517-02H) is a cyclohexanedione oxime herbicide. Cycloxydim can inhibits the acetyl-CoA carboxylase .
    Cycloxydim
  • HY-129558
    UK-1

    		HCV Infection Cancer
    UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities . UK-1 also inhibits HCV replication .
    UK-1
  • HY-10634R
    AMG 517 (Standard)

    		Reference Standards TRP Channel Neurological Disease
    AMG 517 (Standard) is the analytical standard of AMG 517. This product is intended for research and analytical applications. AMG 517 is a potent and selective vanilloid receptor-1 (TRPV1) antagonist with an IC50 of 0.5 nM.
    AMG 517 (Standard)
  • HY-P2360A
    G12 TFA

    Ras 5-17 TFA

    		 Ras Others
    G12 (Ras 5-17) TFA is a wild-type Ras peptide consisted of amino acids 5-17 (KLVVVGAGGVGKS). G12 TFA can be used as a control of mutant Ras peptides studies (such V12) .
    G12 TFA
  • HY-R01557
    hsa-miR-517-5p mimic

    		MicroRNA Cancer
    hsa-miR-517-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    hsa-miR-517-5p mimic
    hsa-miR-517-5p mimic
  • HY-D1688
    Flubida-2

    		Fluorescent Dye Others
    Flubida-2 is a cell permeable dye which can be hydrolyzed to Fubi-2 by endoesterases in cells (after hydrolysis, Ex=492 nm, Em=517 nm). Flubida-2 can be used to detect pH at a specific site in a cell organelle by directing the probe to where avidin fusion proteins are located .
    Flubida-2
  • HY-P1593
    Mini Gastrin I, human

    		Cholecystokinin Receptor Endocrinology Cancer
    Mini Gastrin I, human is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide.
    Mini Gastrin I, human
  • HY-P1593A
    Mini Gastrin I, human TFA

    		Cholecystokinin Receptor Endocrinology Cancer
    Mini Gastrin I, human (TFA) is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide.
    Mini Gastrin I, human TFA
  • HY-173269
    5-HT2A receptor agonist-7

    		5-HT Receptor Others
    5-HT2A receptor agonist-7 (517) is a 5-HT2A modulator, with an EC50 of <100 nM .
    5-HT2A receptor agonist-7
  • HY-155183
    A3AR agonist 1

    		Adenosine Receptor Inflammation/Immunology Cancer
    A3AR agonist 1 (Compound 12) is an A3AR agonist (Ki: 25.8 nM). A3AR agonist 1 stimulates β-arrestin2 recruitment, with an EC50 value of 5.17 nM. A3AR agonist 1 can be used for research of inflammatory diseases, ischemia, cancer, neuropathic pain, liver diseases, etc .
    A3AR agonist 1
  • HY-175588
    EGFR-IN-170

    		EGFR Apoptosis Bcl-2 Family Cancer
    EGFR-IN-170 (Compound 5c) is an EGFR inhibitor with an IC50 of 5.17 μM. EGFR-IN-170 induces apoptosis by inhibiting Bcl2 expression and activating Bax expression with a significantly increased ratio of Bax/Bcl2. EGFR-IN-170 has potent anticancer activity and inhibits the cell growth of resistant lung cancer cells .
    EGFR-IN-170
  • HY-164417
    Kv7.2/Kv7.3 activator-1

    		Potassium Channel Neurological Disease
    Kv7.2/Kv7.3 activator-1 (compound 517) is a potent Kv7.2/Kv7.3 channel activator with an EC50 value of ＜1 µM. Kv7.2/Kv7.3 activator-1 has the potential for the research of neurological diseases .
    Kv7.2/Kv7.3 activator-1
  • HY-168070
    COX-2-IN-48

    		COX NF-κB NO Synthase Inflammation/Immunology
    COX-2-IN-48 (5-25), a COX-2 inhibitor with an IC50 of 51.7 nM for human COX-2, exerts anti-inflammatory and analgesic effects in various rodent models by inhibiting NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, the phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS .
    COX-2-IN-48
  • HY-125881
    ASP1126

    		LPL Receptor Inflammation/Immunology
    ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile .
    ASP1126
  • HY-W952988
    CRBN ligand-517

    		Ligands for E3 Ligase Cancer
    CRBN ligand-517 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-517 can be linked to a target protein ligand via a linker to form a PROTAC.
    CRBN ligand-517
  • HY-R01558
    hsa-miR-517a-3p mimic

    		MicroRNA Cancer
    hsa-miR-517a-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    hsa-miR-517a-3p mimic
    hsa-miR-517a-3p mimic
  • HY-RI01558
    hsa-miR-517a-3p inhibitor

    		MicroRNA Cancer
    hsa-miR-517a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    hsa-miR-517a-3p inhibitor
    hsa-miR-517a-3p inhibitor
  • HY-R01558A
    hsa-miR-517a-3p agomir

    		MicroRNA Cancer
    hsa-miR-517a-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-517a-3p agomir
    hsa-miR-517a-3p agomir
  • HY-RI01558A
    hsa-miR-517a-3p antagomir

    		MicroRNA Cancer
    hsa-miR-517a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-517a-3p antagomir
    hsa-miR-517a-3p antagomir
  • HY-RI01557
    hsa-miR-517-5p inhibitor

    		MicroRNA Cancer
    hsa-miR-517-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    hsa-miR-517-5p inhibitor
    hsa-miR-517-5p inhibitor
  • HY-R01557A
    hsa-miR-517-5p agomir

    		MicroRNA Cancer
    hsa-miR-517-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-517-5p agomir
    hsa-miR-517-5p agomir
  • HY-RI01557A
    hsa-miR-517-5p antagomir

    		MicroRNA Cancer
    hsa-miR-517-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-517-5p antagomir
    hsa-miR-517-5p antagomir
  • HY-125778
    Cochlioquinone B

    		Others Metabolic Disease
    Cochlioquinone is a sesquiterpene metabolite originally isolated from C. miyabeanus. It is a phytotoxin that inhibits root growth of finger millet (E. coracana) and rice plants (O. sativa) by 59.9 and 51.7%, respectively, when used at a concentration of 100 ppm.2 Cochlioquinone B inhibits NADH oxidase and NADH-2,3-dimethoxy-5-pentyl-1,4-benzoquinone reductase from bovine heart mitochondria.
    Cochlioquinone B
  • HY-D3310
    Fluorescein-12-dGTP

    		Fluorescent Dye Others
    Fluorescein-12-dGTP is a fluorescein-labeled deoxyguanosine triphosphate. Fluorescein-12-dGTP incorporates into complementary allele-specific primers at SNP sites, enabling FRET with cationic conjugated polymer PFP via DNA-PFP electrostatic interactions. Fluorescein-12-dGTP incorporates into G-allele-specific primers for homozygous G/G SNP genotypes to enable genotype discrimination. Fluorescein-12-dGTP serves as a fluorescently labeled nucleotide for homogeneous solution-based SNP and FRET genotyping assays (Ex/Em = 498/517 nm) .
    Fluorescein-12-dGTP
  • HY-184145
    AKT1-IN-13

    		Akt PAK PKA MEK ERK Apoptosis Bcl-2 Family Caspase Cancer
    AKT1-IN-13 is an orally active AKT1 inhibitor with an IC50 of 5.17 μM. AKT1-IN-13 also exhibits high inhibitory activity against PAK1, PKA, MAP2K1 (MEK1 / MAPKK1) and MAPK1 (ERK2). AKT1-IN-13 induces cell apoptosis, activates the pro-apoptotic protein BAX, inhibits the anti-apoptotic protein Bcl-2, and activates caspase 3 simultaneously. As a cytotoxic agent, AKT1-IN-13 exerts a killing effect on orthotopically transplanted liver cancer in an AKT1-dependent manner. AKT1-IN-13 can be used in studies related to hepatocellular carcinoma .
    AKT1-IN-13

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