1. GPCR/G Protein
  2. LPL Receptor
  3. ASP1126

ASP1126 

Cat. No.: HY-125881
Handling Instructions

ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile.

For research use only. We do not sell to patients.

ASP1126 Chemical Structure

ASP1126 Chemical Structure

CAS No. : 1228580-11-7

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Description

ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile[1].

IC50 & Target

EC50: 7.12 nM (hS1P1), 517 nM (hS1P3)[1].

In Vivo

ASP1126 (1 and 5 mg/kg, orally once daily for 14 days) significantly prolongs allograft survival[1].
ASP1126 in combination with 0.02 mg/kg tacrolimus notably improves graft survival time[1].

Animal Model: ACI and Lewis rats aged 6 weeks were used as cardiac donors and recipients, respectively[1].
Dosage: 0.2 mg/kg, 1 mg/kg, 5 mg/kg.
Administration: Orally once daily for 14 days.
Result: Significantly prolonged allograft survival (median survival time [MST] =9; 8 days at 1 and 5 mg/kg, respectively, compared with 6 days in the vehicle group).
Molecular Weight

581.93

Formula

C₂₆H₂₆ClF₆NO₅

CAS No.

1228580-11-7

SMILES

O=C(C1CCN(CC2=CC3=CC=C(OCC4=CC=C(OCC(F)(F)F)C(C(F)(F)F)=C4)C=C3OC2)CC1)O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ASP1126ASP 1126ASP-1126LPL ReceptorLysophospholipid ReceptorInhibitorinhibitorinhibit

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ASP1126
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