2. GPCR/G Protein
  3. LPL Receptor
  4. ASP1126

ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile.

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ASP1126 Chemical Structure

ASP1126 Chemical Structure

CAS No. : 1228580-11-7

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ASP1126 Related Antibodies

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Description

ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile[1].

IC50 & Target

EC50: 7.12 nM (hS1P1), 517 nM (hS1P3)[1].
In Vivo

ASP1126 (1 and 5 mg/kg, orally once daily for 14 days) significantly prolongs allograft survival[1].
ASP1126 in combination with 0.02 mg/kg tacrolimus notably improves graft survival time[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ACI and Lewis rats aged 6 weeks were used as cardiac donors and recipients, respectively[1].
Dosage: 0.2 mg/kg, 1 mg/kg, 5 mg/kg.
Administration: Orally once daily for 14 days.
Result: Significantly prolonged allograft survival (median survival time [MST] =9; 8 days at 1 and 5 mg/kg, respectively, compared with 6 days in the vehicle group).
Molecular Weight

581.93

Formula

C26H26ClF6NO5
CAS No.
SMILES

O=C(C1CCN(CC2=CC3=CC=C(OCC4=CC=C(OCC(F)(F)F)C(C(F)(F)F)=C4)C=C3OC2)CC1)O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ASP1126 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASP11261228580-11-7ASP 1126ASP-1126LPL ReceptorLysophospholipid ReceptorInhibitorinhibitorinhibit

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