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Cat. No.: HY-D3310

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Fluorescein-12-dGTP

Fluorescein-12-dGTP is a fluorescein-labeled deoxyguanosine triphosphate. Fluorescein-12-dGTP incorporates into complementary allele-specific primers at SNP sites, enabling FRET with cationic conjugated polymer PFP via DNA-PFP electrostatic interactions. Fluorescein-12-dGTP incorporates into G-allele-specific primers for homozygous G/G SNP genotypes to enable genotype discrimination. Fluorescein-12-dGTP serves as a fluorescently labeled nucleotide for homogeneous solution-based SNP and FRET genotyping assays (Ex/Em = 498/517 nm).

For research use only. We do not sell to patients.

CAS No.: 936107-90-3
Formula: C₄₁H₄₁N₆O₂₀P₃
Molecular Weight:1030.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Fluorescein-12-dGTP Chemical Structure

CAS No.: 936107-90-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

In Vitro

Fluorescein-12-dGTP (2 μM; 60 cycles of denaturation/annealing) enables clear discrimination of rs2241715 G→T SNP genotypes (homozygous G/G, heterozygous G/T, homozygous T/T) from human genomic DNA via single-base extension and PFP-mediated FRET, with genotype-specific FRET ratios ranging from 0.05 to 0.38^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 936107-90-3
Molecular Weight 1030.71
Formula C₄₁H₄₁N₆O₂₀P₃
SMILES

O[C@H]1C[C@H](N(C2=C3C(NC(N)=N2)=O)C=C3C#CCNC(CCCCCNC(C4=CC=C(C(C5=C(C(OC6=C5C=CC(O)=C6)=C7)C=CC7=O)=C4)C(O)=O)=O)=O)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Duan X, et al. Single-nucleotide polymorphism (SNP) genotyping using cationic conjugated polymers in homogeneous solution. Nat Protoc. 2009;4(6):984-991. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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