1. PI3K/Akt/mTOR
  2. PDK-1

BX517 

Cat. No.: HY-13842 Purity: >98.0%
Data Sheet SDS Handling Instructions

BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.

For research use only. We do not sell to patients.
BX517 Chemical Structure

BX517 Chemical Structure

CAS No. : 850717-64-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO $88 In-stock
5 mg $80 In-stock
10 mg $130 In-stock
25 mg $290 In-stock
50 mg $520 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.

IC50 & Target

IC50: 6 nM (PDK1)

In Vitro

BX-517 blocks activation of Akt in tumor cells, is potent with IC50 of 0.1-1.0 μM[1]. BX-517 blocks AKT2 activation in cells with submicromolar potency. BX-517 is 100-fold selective or better against a panel of seven additional Ser/Thr and Tyr kinases[2].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.5423 mL 17.7117 mL 35.4233 mL
5 mM 0.7085 mL 3.5423 mL 7.0847 mL
10 mM 0.3542 mL 1.7712 mL 3.5423 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

282.3

Formula

C₁₅H₁₄N₄O₂

CAS No.

850717-64-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 27 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
BX517
Cat. No.:
HY-13842
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