HN0037

Cat. No.: HY-163529 Pureté: 99.46%: Fiche technique
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HN0037 is a selective, orally active Helicase-primase inhibitor. HN0037 is mainly metabolized by CYP3A4. HN0037 inhibits HSV replication by targeting the viral helicase-primase complex, which consists of three proteins encoded by UL5 (helicase), UL52 (primase), and UL8 (scaffold protein that promotes primer synthesis).

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HN0037 Chemical Structure

CAS No. : 2233566-79-3

Size	Stock	Quantité
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtenir un devis
100 mg	Obtenir un devis

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Other Forms of HN0037:

(S)-HN0037 In-stock

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform HSV:

Voir toutes les isoformes

HSV-1 HSV-2 HSV

Voir tous les produits spécifiques à Isoform Cytochrome P450:

Voir toutes les isoformes

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

Activité biologique
Pureté et documentation
Références
Avis client

Description

IC₅₀ & Target^[1]

CYP3A4

In Vitro

HN0037 is a potent, selective, orally bioavailable agent that exhibits activity against HSV infection in vitro^[1].
HN0037 inhibits HSV replication by targeting the viral helicase-primase complex^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

428.53

Formule

C₂₀H₂₀N₄O₃S₂

CAS No.

2233566-79-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C1=NC(C)=C(S1)S(N)(=O)=O)C)[C@@H]2CC(C=CC(C3=CC=CC=N3)=C4)=C4C2

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Pureté et documentation

Purity: 99.46%

Select Batch:

Fiche technique (267 KB) SDS (252 KB)

COA (249 KB) HNMR (242 KB) RP-HPLC (309 KB) LCMS (232 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Hou J, et al. Pharmacokinetics and Safety Study of HN0037, a Novel Anti-Human Herpes Simplex Virus Inhibitor, in Healthy Volunteers. Clin Pharmacol Drug Dev. 2022;11(12):1467-1473. [Content Brief]

HN0037 Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HN00372233566-79-3HN 0037HN-0037HSVCytochrome P450Herpes simplex virusCYPsherpes simplex virushealthy volunteershelicase-primase inhibitorplaceboInhibitorinhibitorinhibit

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