2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. Isorhamnetin 3,7-di-O-β-D-glucopyranoside

Isorhamnetin 3,7-di-O-β-D-glucopyranoside  (Synonyms: Isorhamnetin-3,7-diglucoside; Isorhamnetin diglucoside)

製品番号: HY-N8196 純度: 98.86%
COA 取扱説明書 Technical Support

Isorhamnetin 3,7-di-O-β-D-glucopyranoside, a major flavonoid compound, is metabolized in vivo by intestinal bacteria to isorhamnetin and that isorhamnetin plays an important role as an antioxidant.

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Isorhamnetin 3,7-di-O-β-D-glucopyranoside

Isorhamnetin 3,7-di-O-β-D-glucopyranoside 構造式

CAS 番号 : 6758-51-6

容量 価格（税別） 在庫状況 数量
5 mg $320 在庫あり
10 mg $480 在庫あり
25 mg $864 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Isorhamnetin 3,7-di-O-β-D-glucopyranoside 関連抗体

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  • 生物活性

  • 純度とドキュメンテーション

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製品説明

Isorhamnetin 3,7-di-O-β-D-glucopyranoside, a major flavonoid compound, is metabolized in vivo by intestinal bacteria to isorhamnetin and that isorhamnetin plays an important role as an antioxidant[1].

体内実験

Isorhamnetin 3,7-di-O-β-D-glucopyranoside (10 or 20 mg/kg of body weight/day for 10 days; p.o.) to rats with streptozotocin-induced diabetes significantly reduced serum levels of glucose and 5-(hydroxymethyl)furfural (5-HMF), which is glycosylated with hemoglobin and is an indicator of oxidative stress[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (5 weeks old, 120-130 g) (STZ-induced diabetic rats had higher glucose and 5-HMF levels than normal rats)[1]
Dosage: 10 or 20 mg/kg of body weight
Administration: P.o.; daily for 10 days
Result: The serum glucose levels of rats given 10 and 20 mg of orally were 510.1 and 492.4 mg/dL, respectively, whereas the control level was 574.2 mg/dL.
分子量

640.54

分子式

C28H32O17
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C(O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=C(C2=CC(OC)=C(C=C2)O)OC3=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C5)C3=C5O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (156.12 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5612 mL 7.8059 mL 15.6118 mL
5 mM 0.3122 mL 1.5612 mL 3.1224 mL
10 mM 0.1561 mL 0.7806 mL 1.5612 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (3.90 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (3.90 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5612 mL 7.8059 mL 15.6118 mL 39.0296 mL
5 mM 0.3122 mL 1.5612 mL 3.1224 mL 7.8059 mL
10 mM 0.1561 mL 0.7806 mL 1.5612 mL 3.9030 mL
15 mM 0.1041 mL 0.5204 mL 1.0408 mL 2.6020 mL
20 mM 0.0781 mL 0.3903 mL 0.7806 mL 1.9515 mL
25 mM 0.0624 mL 0.3122 mL 0.6245 mL 1.5612 mL
30 mM 0.0520 mL 0.2602 mL 0.5204 mL 1.3010 mL
40 mM 0.0390 mL 0.1951 mL 0.3903 mL 0.9757 mL
50 mM 0.0312 mL 0.1561 mL 0.3122 mL 0.7806 mL
60 mM 0.0260 mL 0.1301 mL 0.2602 mL 0.6505 mL
80 mM 0.0195 mL 0.0976 mL 0.1951 mL 0.4879 mL
100 mM 0.0156 mL 0.0781 mL 0.1561 mL 0.3903 mL
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Isorhamnetin 3,7-di-O-β-D-glucopyranoside Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isorhamnetin 3,7-di-O-β-D-glucopyranoside6758-51-6Isorhamnetin-3,7-diglucoside Isorhamnetin diglucosideMitochondrial Metabolismantioxidantratsdiabetesglucose5-HMFlevelsInhibitorinhibitorinhibit

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製品名:
Isorhamnetin 3,7-di-O-β-D-glucopyranoside
製品番号:
HY-N8196
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