1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Moxifloxacin Hydrochloride

Moxifloxacin Hydrochloride (Synonyms: BAY 12-8039)

Cat. No.: HY-66011 Purity: 99.82%
Handling Instructions

Moxifloxacin Hydrochloride (BAY 12-8039) is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.

For research use only. We do not sell to patients.

Moxifloxacin Hydrochloride Chemical Structure

Moxifloxacin Hydrochloride Chemical Structure

CAS No. : 186826-86-8

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Moxifloxacin Hydrochloride:

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1 Publications Citing Use of MCE Moxifloxacin Hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Moxifloxacin Hydrochloride (BAY 12-8039) is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia[1][2].

IC50 & Target

Bacterial[1]

In Vitro

The in vitro activities of Moxifloxacin Hydrochloride (BAY 12-8039) and Amoxicillin are compared by time-kill curve and inhibition of intracellular growth experiments by using a model of bone marrow-derived mouse macrophages infected by L. monocytogenes EGDe. Moxifloxacin acts much more rapidly, beginning to exert its effects in the first 3 h and achieving complete broth sterilization within 24 h of incubation. Moxifloxacin appears to have a protective effect against macrophage lysis, as many cells are still viable after 24 h of incubation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Moxifloxacin (BAY 12-8039; 12 mg/kg; intravenous injection; once-three times per day; for 7 days; white male Wistar rats) treatment every 8 hours is accompanied by longer survival. Tissue cultures 30 hours after bacterial challenge shows considerably less bacterial overgrowth in the spleens and lungs of moxifloxacin-treated than in salinetreated animals and without being toxic[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 144 white male Wistar rats (18-22 weeks; 300-400 g) infected Stenotrophomonas maltophilia[4]
Dosage: 12 mg/kg
Administration: Intravenous injection; once per day, twice per day, three times per day; for 7 days
Result: Showed considerably less bacterial overgrowth in the spleens and lungs and without being toxic.
Clinical Trial
Molecular Weight

437.89

Formula

C₂₁H₂₅ClFN₃O₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (70.79 mM)

H2O : 16.67 mg/mL (38.07 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2837 mL 11.4184 mL 22.8368 mL
5 mM 0.4567 mL 2.2837 mL 4.5674 mL
10 mM 0.2284 mL 1.1418 mL 2.2837 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.82%

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Moxifloxacin Hydrochloride
Cat. No.:
HY-66011
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