Moxifloxacin hydrochloride monohydrate
Based on 23 publication(s) in Google Scholar
Moxifloxacin (BAY 12-8039) hydrochloride monohydrate is an orally active bacterial inhibitor that is effective against Streptococcus pneumoniae. Moxifloxacin hydrochloride monohydrate can be used in tuberculosis research.
For research use only. We do not sell to patients.
- Purity: 98.17%
- CAS No.: 192927-63-2
- Formula: C21H27ClFN3O5
- Molecular Weight:455.91
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Moxifloxacin hydrochloride monohydrate
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Nat Microbiol. 2023 Mar;8(3):410-423. [Abstract]
- Nat Commun. 2022 Mar 2;13(1):1116. [Abstract]
- mLife. 2025 Apr 15;4(2):155-168. [Abstract]
- Cell Mol Life Sci. 2022 Jul 22;79(8):441. [Abstract]
- Int J Pharm. 2026 Jan 5:687:126356. [Abstract]
- J Clin Microbiol. 2025 Aug 20:e0084125. [Abstract]
- Antibiotics (Basel). 2022 Feb 1;11(2):192. [Abstract]
- Molecules. 2025 Mar 9;30(6):1224. [Abstract]
- FASEB J. 2026 Feb 28;40(4):e71586. [Abstract]
- Antimicrob Agents Chemother. 2025 Sep 11:e0079525. [Abstract]
- Antimicrob Agents Chemother. 2025 Jul 2;69(7):e0024925. [Abstract]
- Antimicrob Agents Chemother. 2024 Dec 5;68(12):e0094524. [Abstract]
- Antimicrob Agents Chemother. 2024 Dec 5;68(12):e0105124. [Abstract]
- Microbiol Spectr. 2025 Jul;13(7):e0307424. [Abstract]
- ACS Chem Biol. 2022 Jan 21;17(1):39-53. [Abstract]
- Water. 2025 Jun 6.
- Infect Drug Resist. 2021 Sep 14;14:3729-3736. [Abstract]
- SSRN. 2025 Oct 14.
- SSRN. 2025 Oct 20.
- Authorea. 2025 Sep 17.
- bioRxiv. 2024 Nov 06.
- Universität zu Lübeck. 2022.
Customer Validation & Images
-
Cell Proliferation/Viability Assay
-
WB
-
Cell Imaging/Staining
-
Apoptosis Analysis
-
IF
All Antibiotic Isoforms
More
Biological Activity
Chemical Information
-
CAS No. 192927-63-2
-
Appearance Solid
-
Molecular Weight 455.91
-
Formula C21H27ClFN3O5
-
Color Off-white to light yellow
-
SMILES
O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N(C4)C[C@]5([H])[C@@]4([H])CCCN5)=C3OC)C1=O)O.Cl.O
-
Synonyms
BAY 12-8039 monohydrate
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (23)
-
Journal Impact Factor
-
Most Recent
-
Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Nat Microbiol
Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains. [Abstract]2023 Mar;8(3):410-423. PMID: 36759752 -
Nat Commun
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]2022 Mar 2;13(1):1116. PMID: 35236849 -
mLife
Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria. [Abstract]2025 Apr 15;4(2):155-168. PMID: 40313980 -
Cell Mol Life Sci
2022 Jul 22;79(8):441. PMID: 35864358
Moxifloxacin hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2022 Jul 22;79(8):441. [Abstract]
Moxifloxacin Hydrochloride (0.8, 1.6, 3.2, 6.3, 12.5, 25, 50, 100 μM; 10 days) significantly decreased the death rate of the SMA MNs, at levels similar to the healthy cells.
Moxifloxacin hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2022 Jul 22;79(8):441. [Abstract]
Moxifloxacin Hydrochloride (75 mg/kg; s,c,; daily from P2 to P12) increased the protein expression of SMN in the spinal cord of delta 7 mice.
Moxifloxacin hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2022 Jul 22;79(8):441. [Abstract]
Moxifloxacin Hydrochloride (75 mg/kg; s,c,; daily from P2 to P12) increased stereological MN counts in the lumbar (L3–L5) spinal cord tract of delta 7 mice.
Moxifloxacin hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2022 Jul 22;79(8):441. [Abstract]
Moxifloxacin Hydrochloride (75 mg/kg; s,c,; daily from P2 to P12) increased the percentage of Cleaved Caspase 3-positive cells in the ventral horns of the lumbar spinal cord tract (L1-L3)of delta 7 mice.
Moxifloxacin hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2022 Jul 22;79(8):441. [Abstract]
Moxifloxacin Hydrochloride (75 mg/kg; s,c,; daily from P2 to P12) significantly reduced the percentage of GFAP-immunopositive profile density by approximately 48% in delta 7 mice with respect to the control group in the ventral horns of the lumbar spinal cord tract of delta 7 mice.
-
Int J Pharm
Modelling lung permeability of pharmaceuticals: The effectiveness of biomimetic open tubular capillary electrochromatography and immobilised artificial membrane chromatography coupled with mass spectrometry. [Abstract]2026 Jan 5:687:126356. PMID: 41205685 -
J Clin Microbiol
Luciferase reporter mycobacteriophage (TM4:: GeNL) enables rapid assessment of drug susceptibilities and inducible macrolide resistance in Mycobacterium abscessus complex. [Abstract]2025 Aug 20:e0084125. PMID: 40833127 -
Antibiotics (Basel)
Antibacterial Activity of the Novel Drug Gepotidacin against Stenotrophomonas maltophilia-An In Vitro and In Vivo Study. [Abstract]2022 Feb 1;11(2):192. PMID: 35203795 -
Molecules
Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]2025 Mar 9;30(6):1224. PMID: 40142001 -
FASEB J
Moxifloxacin Inhibits Neutrophil Responses to Immune Complexes and Ameliorates Skin Inflammation in a Model of Pemphigoid Diseases. [Abstract]2026 Feb 28;40(4):e71586. PMID: 41676900 -
Antimicrob Agents Chemother
Incorporation of macrophage immune stresses into an intracellular assay of drug tolerance in Mycobacterium tuberculosis. [Abstract]2025 Sep 11:e0079525. PMID: 40934365 -
Antimicrob Agents Chemother
An enoyl-ACP reductase inhibitor, NITD-916, expresses anti- Mycobacterium abscessus activity. [Abstract]2025 Jul 2;69(7):e0024925. PMID: 40407337 -
Antimicrob Agents Chemother
2024 Dec 5;68(12):e0094524. PMID: 39470202 -
Antimicrob Agents Chemother
Multidrug tolerance conferred by loss-of-function mutations in anti-sigma factor RshA of Mycobacterium abscessus. [Abstract]2024 Dec 5;68(12):e0105124. PMID: 39470195 -
Microbiol Spectr
Antimicrobial resistance of rapidly growing mycobacteria isolated from companion animals in Taiwan. [Abstract]2025 Jul;13(7):e0307424. PMID: 40387379 -
ACS Chem Biol
Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. [Abstract]2022 Jan 21;17(1):39-53. PMID: 34908399 -
-
Infect Drug Resist
In vitro Synergism of Six Antituberculosis Agents Against Drug-Resistant Mycobacterium tuberculosis Isolated from Retreatment Tuberculosis Patients. [Abstract]2021 Sep 14;14:3729-3736. PMID: 34548797 -
-
-
-
-
Solvent & Solubility
DMSO : 35 mg/mL (76.77 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
-
Handling Instructions (2659 KB)
References
[1]. Pestova E, et al. Intracellular targets of moxifloxacin: a comparison with other fluoroquinolones. J Antimicrob Chemother. 2000 May;45(5):583-90. [Content Brief]
[2]. Miyazaki E, et al. Moxifloxacin (BAY12-8039), a new 8-methoxyquinolone, is active in a mouse model of tuberculosis. Antimicrob Agents Chemother. 1999 Jan;43(1):85-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1934 mL | 10.9671 mL | 21.9342 mL | 54.8354 mL |
| 5 mM | 0.4387 mL | 2.1934 mL | 4.3868 mL | 10.9671 mL | |
| 10 mM | 0.2193 mL | 1.0967 mL | 2.1934 mL | 5.4835 mL | |
| 15 mM | 0.1462 mL | 0.7311 mL | 1.4623 mL | 3.6557 mL | |
| 20 mM | 0.1097 mL | 0.5484 mL | 1.0967 mL | 2.7418 mL | |
| 25 mM | 0.0877 mL | 0.4387 mL | 0.8774 mL | 2.1934 mL | |
| 30 mM | 0.0731 mL | 0.3656 mL | 0.7311 mL | 1.8278 mL | |
| 40 mM | 0.0548 mL | 0.2742 mL | 0.5484 mL | 1.3709 mL | |
| 50 mM | 0.0439 mL | 0.2193 mL | 0.4387 mL | 1.0967 mL | |
| 60 mM | 0.0366 mL | 0.1828 mL | 0.3656 mL | 0.9139 mL |
Moxifloxacin hydrochloride monohydrate Related Classifications
HY-W353258 Related Classifications
Powered by Bioz