N-Acetyl-D-galactosamine, 98%

Art. -Nr.: HY-128852 Reinheit: 99.85%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets. N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin.

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N-Acetyl-D-galactosamine, 98% Chemische Struktur

CAS. Nr. : 14215-68-0

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Galectin Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Galectin-1 Galectin-3 Galectin-4 Galectin-8

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Human Endogenous Metabolite Microbial Metabolite

Biologische Aktivität
Reinheit & Dokumentation
Verweise
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Beschreibung

N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets^[1]. N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin^[2].

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

N-Acetyl-D-galactosamine (GalNAc) (50nm; 4 hours) decreases the expression of occludin mRNA and claudin-3 mRNA by 1.6% and 2.7%^[1].
N-Acetyl-D-galactosamine (GalNAc) (50nm; 4 hours) lowers the protein expression of occludin and claudin-3 by 4.3% and 7.2%, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:	IPEC-J2 cell
Concentration:	50 nM
Incubation Time:	4 hours
Result:	Observed a slight reduction in mRNA expression of occludin and claudin-3.

Western Blot Analysis^[1]

Cell Line:	IPEC-J2 cell
Concentration:	50 nM
Incubation Time:	4 hours
Result:	Alleviated the damage of tight junction expressions at protein level.

Molekulargewicht

221.21

Formel

C₈H₁₅NO₆

CAS. Nr.

14215-68-0

Appearance

Solid

Color

White to off-white

SMILES

CC(N[C@@H]1[C@H]([C@H]([C@H](O[C@@H]1O)CO)O)O)=O

Structure Classification

Initial Source

Endogenous metabolite

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 125 mg/mL (565.07 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5206 mL	22.6030 mL	45.2059 mL
5 mM	0.9041 mL	4.5206 mL	9.0412 mL
10 mM	0.4521 mL	2.2603 mL	4.5206 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 99.85%

Select Batch:

Data Sheet (275 KB) SDS (396 KB)

COA (250 KB) HNMR (256 KB) RP-HPLC (237 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Zhao B, et al. N-Acetyl-d-galactosamine prevents soya bean agglutinin-induced intestinal barrier dysfunction in intestinal porcine epithelial cells. J Anim Physiol Anim Nutr (Berl). 2019 Jul;103(4):1198-1206. [Content Brief]

[2]. Sadanandan R, et al. Isolation, Purification and Characterisation of a D-galactose and N-acetyl-D-galactosamineSpecific Lectin from Marine Sponge Fasciospongia cavernosa. Protein Pept Lett. 2018;25(9):871-877. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.5206 mL	22.6030 mL	45.2059 mL	113.0148 mL
	5 mM	0.9041 mL	4.5206 mL	9.0412 mL	22.6030 mL
	10 mM	0.4521 mL	2.2603 mL	4.5206 mL	11.3015 mL
	15 mM	0.3014 mL	1.5069 mL	3.0137 mL	7.5343 mL
	20 mM	0.2260 mL	1.1301 mL	2.2603 mL	5.6507 mL
	25 mM	0.1808 mL	0.9041 mL	1.8082 mL	4.5206 mL
	30 mM	0.1507 mL	0.7534 mL	1.5069 mL	3.7672 mL
	40 mM	0.1130 mL	0.5651 mL	1.1301 mL	2.8254 mL
	50 mM	0.0904 mL	0.4521 mL	0.9041 mL	2.2603 mL
	60 mM	0.0753 mL	0.3767 mL	0.7534 mL	1.8836 mL
	80 mM	0.0565 mL	0.2825 mL	0.5651 mL	1.4127 mL
	100 mM	0.0452 mL	0.2260 mL	0.4521 mL	1.1301 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.