N-Desethyl amodiaquine-d₅

製品番号: HY-128554S 純度: 99.9%: Data Sheet SDS COA 取扱説明書
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N-Desethyl amodiaquine-d₅ is the deuterium labeled N-Desethyl amodiaquine. N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC₅₀ values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

N-Desethyl amodiaquine-d₅ 構造式

CAS 番号 : 1173023-19-2

容量	価格（税別）	在庫状況	数量
1 mg	$440	在庫あり	Estimated Time of Arrival: December 31
5 mg	$820	お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
10 mg		お問い合わせ
50 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other Forms of N-Desethyl amodiaquine-d₅:

N-Desethyl amodiaquine 在庫あり
N-Desethyl amodiaquine dihydrochloride 在庫あり
N-Desethyl amodiaquine-d₅ dihydrochloride 在庫あり

Parasite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

体外実験

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

332.84

分子式

C₁₈H₁₃D₅ClN₃O

CAS 番号

1173023-19-2

Unlabeled CAS

79352-78-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

ClC(C=C1)=CC2=C1C(NC3=CC(CNC([2H])([2H])C([2H])([2H])[2H])=C(C=C3)O)=CC=N2

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (300.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0044 mL	15.0222 mL	30.0445 mL
5 mM	0.6009 mL	3.0044 mL	6.0089 mL
10 mM	0.3004 mL	1.5022 mL	3.0044 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.9%

Select Batch:

データシート (272 KB) SDS (480 KB)

COA (249 KB) HNMR (170 KB) RP-HPLC (92 KB) LCMS (89 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0044 mL	15.0222 mL	30.0445 mL	75.1112 mL
	5 mM	0.6009 mL	3.0044 mL	6.0089 mL	15.0222 mL
	10 mM	0.3004 mL	1.5022 mL	3.0044 mL	7.5111 mL
	15 mM	0.2003 mL	1.0015 mL	2.0030 mL	5.0074 mL
	20 mM	0.1502 mL	0.7511 mL	1.5022 mL	3.7556 mL
	25 mM	0.1202 mL	0.6009 mL	1.2018 mL	3.0044 mL
	30 mM	0.1001 mL	0.5007 mL	1.0015 mL	2.5037 mL
	40 mM	0.0751 mL	0.3756 mL	0.7511 mL	1.8778 mL
	50 mM	0.0601 mL	0.3004 mL	0.6009 mL	1.5022 mL
	60 mM	0.0501 mL	0.2504 mL	0.5007 mL	1.2519 mL
	80 mM	0.0376 mL	0.1878 mL	0.3756 mL	0.9389 mL
	100 mM	0.0300 mL	0.1502 mL	0.3004 mL	0.7511 mL