NXP800 (Synonyms: CCT361814)

Name: NXP800
Brand: MedChemExpress
SKU: HY-145927
Rating: 5.0 (3 reviews)

Cat. No.: HY-145927 Purity: 99.86%: Data Sheet
COA

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NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research.

For research use only. We do not sell to patients.

CAS No. : 1693734-80-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 3 publication(s) in Google Scholar

3 Publications Citing Use of MCE NXP800

Apoptosis Analysis

IHC

Cell Proliferation/Viability Assay

: NXP800 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2026 Mar 19;27(6):2781.; Cells treated with NXP800 at 50 nM concentration, either alone or in association with 5 OLA. Apoptosis was assessed in HLF.

: NXP800 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2026 Mar 19;27(6):2781.; The P151 and P558 patient-derived organoids (PDOs) were treated with 500 nM NXP800 for 48 h, and levels of the proliferation marker Ki67, the apoptosis marker cleaved caspase 3, and the DNA damage marker phosphorylated/activated (p) histone H2A.X were evaluated immunohistochemically.

: NXP800 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2026 Mar 19;27(6):2781.; HCC PDOs were treated with NXP800 for 48 h, and cell viability was evaluated via CellTiter-Glo®3D Luminescent Cell Viability Assay.

: NXP800 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Oct 30;25(21):11657. [Abstract]; MIA PaCa-2 cells treated with the indicated dose of NXP800 (0, 25, 50 nM) for 24 h. Protein levels were detected by using Western blotting.

: NXP800 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Oct 30;25(21):11657. [Abstract]; MIA PaCa-2 cells were treated with 25 nM NXP800 for 2 h, followed by 1 mM CuCl2 for 24 h. Aggresomes were imaged using a fluorescence microscope.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research^[1]^[2].

IC₅₀ & Target^[1]

HSF1

Cellular Effect

Cell Line	Type	Value	Description	References
SK-OV-3	GI₅₀	8.5 1 Compound: 22; CCT361814	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 96 hrs by resazurin dye based celltiter-blue viability assay Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 96 hrs by resazurin dye based celltiter-blue viability assay	[PMID: 37017629]
SK-OV-3	IC₅₀	94 1 Compound: 22; CCT361814	Inhibition of 17-AAG induced HSP72-expression in human SK-OV-3 cells incubated for 18 hrs by ELISA Inhibition of 17-AAG induced HSP72-expression in human SK-OV-3 cells incubated for 18 hrs by ELISA	[PMID: 37017629]
SK-OV-3	GI₅₀	8.5 1 Compound: 22; CCT361814	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 96 hrs by resazurin dye based celltiter-blue viability assay Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 96 hrs by resazurin dye based celltiter-blue viability assay	[PMID: 37017629]
SK-OV-3	IC₅₀	94 1 Compound: 22; CCT361814	Inhibition of 17-AAG induced HSP72-expression in human SK-OV-3 cells incubated for 18 hrs by ELISA Inhibition of 17-AAG induced HSP72-expression in human SK-OV-3 cells incubated for 18 hrs by ELISA	[PMID: 37017629]

In Vitro

NXP800 (example 169) inhibits U20S cells viability (IC₅₀=0.056 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NXP800 (35 mg/kg; po; once daily for 20 days) inhibits the established SK-OV-3 human ovarian cancer solid tumor xenografts grown subcutaneously, with tumor growth inhibition (TGI) of 120% relative to control^[2].

Pharmacokinetic Analysis^[2]

Species	Route	Dose (mg/kg)	T_max (h)	AUC_last (ng·h/mL)	Cl_tb (mL/min/kg)	t_1/2 (h)	F (%)	AUC_u^0-t (h·nM)	Free C_av^0-24h (nM)	Cl_u (mL/min/kg)
mouse	po/iv	5/5	2.0	6000 (7800-4600) (po)	10 (10-9.7) (iv)	4.0	42 (po)	72	3.3	830 (iv)
rat	po/iv	5/1	6.0	2600 (po)	24 (iv)	3.1	45 (po)	86	3.7	730 (iv)
dog	po/iv	2.5/0.5	2.0	250 (po)	21 (iv)	1.4	9.1 (po)	35	1.9	150 (iv)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

569.63

Formula

C₃₂H₃₂FN₅O₄

CAS No.

1693734-80-3

Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(C1=CC=C2OCCOC2=C1)NC3=CC=C(C(NC(C4=CC5=C(N=C(CN6CCN(CC6)CC)C=C5)C=C4)=O)=C3)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (175.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7555 mL	8.7776 mL	17.5553 mL
5 mM	0.3511 mL	1.7555 mL	3.5111 mL
10 mM	0.1756 mL	0.8778 mL	1.7555 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (272 KB) SDS (254 KB)

COA (244 KB) HNMR (277 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Keith Jones, et al. Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1. WO2015049535A1.

[2]. Pasqua AE, et al. HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies. J Med Chem. 2023 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7555 mL	8.7776 mL	17.5553 mL	43.8881 mL
	5 mM	0.3511 mL	1.7555 mL	3.5111 mL	8.7776 mL
	10 mM	0.1756 mL	0.8778 mL	1.7555 mL	4.3888 mL
	15 mM	0.1170 mL	0.5852 mL	1.1704 mL	2.9259 mL
	20 mM	0.0878 mL	0.4389 mL	0.8778 mL	2.1944 mL
	25 mM	0.0702 mL	0.3511 mL	0.7022 mL	1.7555 mL
	30 mM	0.0585 mL	0.2926 mL	0.5852 mL	1.4629 mL
	40 mM	0.0439 mL	0.2194 mL	0.4389 mL	1.0972 mL
	50 mM	0.0351 mL	0.1756 mL	0.3511 mL	0.8778 mL
	60 mM	0.0293 mL	0.1463 mL	0.2926 mL	0.7315 mL
	80 mM	0.0219 mL	0.1097 mL	0.2194 mL	0.5486 mL
	100 mM	0.0176 mL	0.0878 mL	0.1756 mL	0.4389 mL

NXP800 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NXP8001693734-80-3CCT361814NXP 800NXP-800CCT 361814CCT-361814HSPHeat shock proteinsInhibitorinhibitorinhibit

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NXP800 (Synonyms: CCT361814)

Customer Review

NXP800 Related Antibodies

3 Publications Citing Use of MCE NXP800

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All HSP Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

NXP800 Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

NXP800 Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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