2. Metabolic Enzyme/Protease Apoptosis
  3. Endogenous Metabolite Ferroptosis
  4. Itaconic acid

イタコン酸  (Synonyms: Itaconic acid; Methylenesuccinic acid)

製品番号: HY-Y0520 純度: 99.88%
COA 取扱説明書 Technical Support

Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect.

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CAS 番号 : 97-65-4

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100 mg $66 在庫あり
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500 mg   お問い合わせ  

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カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of Itaconic acid:

イタコン酸 関連抗体

Top Publications Citing Use of Products
Cell Imaging/Staining
Apoptosis Analysis
WB
Histological Imaging/Staining
In Vivo Efficacy Study

    Itaconic acid purchased from MedChemExpress. Usage Cited in: Apoptosis. 2025 Apr;30(3-4):991-1004.  [Abstract]

    Itaconic acid (Itaconate, IA; 80 μM). EDU method to detect the survival of HT22 cells.

    Itaconic acid purchased from MedChemExpress. Usage Cited in: Apoptosis. 2025 Apr;30(3-4):991-1004.  [Abstract]

    Itaconic acid (Itaconate, IA; 80 μM). Tunel to detect apoptosis of HT22 cells.

    Itaconic acid purchased from MedChemExpress. Usage Cited in: Apoptosis. 2025 Apr;30(3-4):991-1004.  [Abstract]

    Itaconic acid (Itaconate, IA; 80 μM). Representative western blot images and statistical analysis of ferroptosis-related proteins.

    Itaconic acid purchased from MedChemExpress. Usage Cited in: Apoptosis. 2025 Apr;30(3-4):991-1004.  [Abstract]

    Itaconic acid (Itaconate, IA; 80 μM). The effect of itaconate on lipid peroxidation level and Fe2+ level in HT22 cells.

    Itaconic acid purchased from MedChemExpress. Usage Cited in: Apoptosis. 2025 Apr;30(3-4):991-1004.  [Abstract]

    Itaconic acid (Itaconate, IA; 5 mg/kg; ip). Assessment of cell death in mice’s cortical brain tissue by HE staining.

    Itaconic acid purchased from MedChemExpress. Usage Cited in: Apoptosis. 2025 Apr;30(3-4):991-1004.  [Abstract]

    Itaconic acid (Itaconate, IA; 5 mg/kg; ip). Measurement of water content in the left hemisphere of mice’s brain by wet-dry weight method.

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect[1][2][4][5].

    IC50 & Target

    Human Endogenous Metabolite

     

    体外実験

    Itaconic acid (2–8 mM, 24 h) induces ferroptosis by activating ferritinophagy in PANC1 cells[3].
    Itaconic acid (10 mM, 24 h) inhibits LPS-induced inflammatory cytokines in RAW264.7 cells[4].
    Itaconic acid (10 mM, 24 h) promotes the pentose phosphate pathway (PPP) and NADPH oxidase activity in RAW264.7 cells[4].
    Itaconic acid (10 mM, 24-72 h) inhibits cell viability of cerebellar granule cells (CGC) and inhibits ADP-stimulated respiration in permeabilized CGC cells[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    イタコン酸 関連抗体
    分子量

    130.10

    分子式

    C5H6O4
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O)C(CC(O)=O)=C
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 27.78 mg/mL (213.53 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 7.6864 mL 38.4320 mL 76.8639 mL
    5 mM 1.5373 mL 7.6864 mL 15.3728 mL
    10 mM 0.7686 mL 3.8432 mL 7.6864 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 25 mg/mL (192.16 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.98%

    COA (244 KB) HNMR (217 KB) RP-HPLC (241 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 7.6864 mL 38.4320 mL 76.8639 mL 192.1599 mL
    5 mM 1.5373 mL 7.6864 mL 15.3728 mL 38.4320 mL
    10 mM 0.7686 mL 3.8432 mL 7.6864 mL 19.2160 mL
    15 mM 0.5124 mL 2.5621 mL 5.1243 mL 12.8107 mL
    20 mM 0.3843 mL 1.9216 mL 3.8432 mL 9.6080 mL
    25 mM 0.3075 mL 1.5373 mL 3.0746 mL 7.6864 mL
    30 mM 0.2562 mL 1.2811 mL 2.5621 mL 6.4053 mL
    40 mM 0.1922 mL 0.9608 mL 1.9216 mL 4.8040 mL
    50 mM 0.1537 mL 0.7686 mL 1.5373 mL 3.8432 mL
    60 mM 0.1281 mL 0.6405 mL 1.2811 mL 3.2027 mL
    80 mM 0.0961 mL 0.4804 mL 0.9608 mL 2.4020 mL
    100 mM 0.0769 mL 0.3843 mL 0.7686 mL 1.9216 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Itaconic acid Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Itaconic acid97-65-4Methylenesuccinic acidEndogenous MetaboliteFerroptosispolymerschemicalsand fuelsfungimacrophageInhibitorinhibitorinhibit

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