2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. (R)-3-Hydroxybutanoic acid sodium

(R)-3-Hydroxybutanoic acid (sodium)  (Synonyms: (R)-(-)-3-Hydroxybutanoic acid (sodium); (R)-3-Hydroxybutyric acid (sodium); (R)-3-ヒドロキシブタン酸ナトリウム)

製品番号: HY-W015851 純度: 99.90%
COA 取扱説明書 Technical Support

(R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 13613-65-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Solid
500 mg $30 在庫あり
1 g $50 在庫あり
5 g $150 在庫あり
10 g $210 在庫あり
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 6 publication(s) in Google Scholar

Other Forms of (R)-3-Hydroxybutanoic acid sodium:

(R)-3-Hydroxybutanoic acid (sodium) 関連抗体

Top Publications Citing Use of Products

    (R)-3-Hydroxybutanoic acid sodium purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 May 31;10(22):eadk5011.  [Abstract]

    (R)-3-Hydroxybutanoic acid (3-HB) (0.5 mM; 6-24 h) significantly up-regulated the mRNA levels of Gpld1 in HepG2 cells.

    (R)-3-Hydroxybutanoic acid sodium purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 May 31;10(22):eadk5011.  [Abstract]

    (R)-3-Hydroxybutanoic acid (3-HB) (0.5 mM; 6-24 h) significantly up-regulated the protein level of Gpld1 in HepG2 cells.

    (R)-3-Hydroxybutanoic acid sodium purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 May 31;10(22):eadk5011.  [Abstract]

    Fluorescence microscopy of VSV-GFP viruses in HepG2 cells treated with PBS (Ctrl) or (R)-3-Hydroxybutanoic acid (3-HB) (5 mM) for 24 hours and then infected with VSV-GFP (MOI = 1.0; 24 hours). Scale bars, 200 μm.

    (R)-3-Hydroxybutanoic acid sodium purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 May 31;10(22):eadk5011.  [Abstract]

    ELISA analysis of mIFN-β protein levels in the serum of mice administrated with (R)-3-Hydroxybutanoic acid (3-HB) (3 mmol/kg, i.v.) or PBS (Ctrl) for 24 hours. The results showed that 3-HB administration up-regulated serum IFN-I levels.

    (R)-3-Hydroxybutanoic acid sodium purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 May 31;10(22):eadk5011.  [Abstract]

    HE staining of the livers from Gpld1+/+ and Gpld1−/− mice was performed. Gpld1+/+ and Gpld1−/− mice were administrated with (R)-3-Hydroxybutanoic acid (3-HB) (3 mmol/kg; i.v.) or PBS for 24 hours, and then infected with VSV (1 × 108 PFU/g of body weight; intranasal) for 48 hours. Scale bar: 100 μm.

    (R)-3-Hydroxybutanoic acid sodium purchased from MedChemExpress. Usage Cited in: Am J Physiol Cell Physiol. 2024 Jun 1;326(6):C1710-C1720.  [Abstract]

    Exposure to 3 mM (R)-3-Hydroxybutanoic acid sodium (d-βOHB, 3 h) increased basal glucose uptake, significantly higher than in the glucose, substrate-free, and 3 mM 1-βOHB groups.

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    (R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[1][2].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    体外実験

    (R)-3-Hydroxybutanoic acid sodium is a metabolite converted from acetoacetic acid. Enhanced hepatic fatty acid oxidation results in the increased production of acetoacetic acid which is in turn converted to (R)-3-Hydroxybutanoic acid sodium by a reaction catalyzed by 3-hydroxybutyrate dehydrogenase[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    (R)-3-Hydroxybutanoic acid (sodium) 関連抗体
    分子量

    126.09

    分子式

    C4H7NaO3
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    C[C@H](CC(O[Na])=O)O
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 100 mg/mL (793.08 mM; Need ultrasonic)

    DMSO : 50 mg/mL (396.54 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 7.9308 mL 39.6542 mL 79.3084 mL
    5 mM 1.5862 mL 7.9308 mL 15.8617 mL
    10 mM 0.7931 mL 3.9654 mL 7.9308 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (19.83 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (19.83 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (793.08 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.90%

    COA (248 KB) HNMR (110 KB) RP-HPLC (234 KB) MS (70 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 7.9308 mL 39.6542 mL 79.3084 mL 198.2711 mL
    5 mM 1.5862 mL 7.9308 mL 15.8617 mL 39.6542 mL
    10 mM 0.7931 mL 3.9654 mL 7.9308 mL 19.8271 mL
    15 mM 0.5287 mL 2.6436 mL 5.2872 mL 13.2181 mL
    20 mM 0.3965 mL 1.9827 mL 3.9654 mL 9.9136 mL
    25 mM 0.3172 mL 1.5862 mL 3.1723 mL 7.9308 mL
    30 mM 0.2644 mL 1.3218 mL 2.6436 mL 6.6090 mL
    40 mM 0.1983 mL 0.9914 mL 1.9827 mL 4.9568 mL
    50 mM 0.1586 mL 0.7931 mL 1.5862 mL 3.9654 mL
    60 mM 0.1322 mL 0.6609 mL 1.3218 mL 3.3045 mL
    80 mM 0.0991 mL 0.4957 mL 0.9914 mL 2.4784 mL
    100 mM 0.0793 mL 0.3965 mL 0.7931 mL 1.9827 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    (R)-3-Hydroxybutanoic acid sodium Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    (R)-3-Hydroxybutanoic acid13613-65-5(R)-(-)-3-Hydroxybutanoic acid(R)-3-Hydroxybutyric acidEndogenous MetaboliteendogenousmetaboliteacetoaceticvitaminsantibioticspheromonesInhibitorinhibitorinhibit

    最近チェックした製品:

    オンラインお問い合わせ

    Your information is safe with us. * Required Fields.

    製品名

    		  

    カスタマ需要量 *

    お名前 *

    		 

    タイトル

    メールアドレス *

    		 

    電話番号 *

    デパートメント

    		 

    組纖名 *

    市区町村

    都道府県

    国或いは地域 *

    		      

    必ず会社名を記載ください。個人への返信は行いません。

    備考

    バルクお問い合わせ

    Inquiry Information

    製品名:
    (R)-3-Hydroxybutanoic acid sodium
    製品番号:
    HY-W015851
    数量:
    MCE 日本正規代理店:

    カスタマーレビュー

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    製品名

    		  

    Lot #

    お名前 *

    		 

    メールアドレス *

    電話番号 *

    		 

    部門 *

    組纖名 *

    		 

    国或いは地域 *

    備考

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.