Ecopipam hydrobromide (Synonyms: SCH 39166 hydrobromide)

Name: Ecopipam hydrobromide
Brand: MedChemExpress
SKU: HY-110033
Rating: 4.5 (0 reviews)

Cat. No.: HY-110033 Pureza: 99.0%: Ficha de datos
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Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with K_is of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (K_i=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia and obesity.

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Ecopipam hydrobromide Estructura química

No. CAS : 2587360-22-1

Tamaño	Stock	Cantidad
1 mg	En stock	Estimated Time of Arrival: December 31
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Other Forms of Ecopipam hydrobromide:

Ecopipam hydrochloride In-stock
Ecopipam In-stock

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Ver todos los productos específicos de isoformas Dopamine Receptor:

Ver todas las isoformas

Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Ver todos los productos específicos de isoformas 5-HT Receptor:

Ver todas las isoformas

5-HT Receptor 5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor

Ver todos los productos específicos de isoformas Adrenergic Receptor:

Ver todas las isoformas

α adrenergic receptor β adrenergic receptor

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Descripciòn

IC₅₀ & Target^[1]

D₁ Receptor

1.2 nM (Ki)

D₅ Receptor

2.0 nM (Ki)

D₂ Receptor

980 nM (Ki)

D₄ Receptor

5520 nM (Ki)

5-HT Receptor

80 nM (Ki)

Alpha-2A adrenergic receptor

731 nM (Ki)

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	12.6 μM Compound: Ecopipam	Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis	[PMID: 20966043]
HepG2	EC₅₀	4 μM Compound: Ecopipam	Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis	[PMID: 20966043]

In Vitro

Ecopipam (2 μM) hydrobromide completely abolishes the proconvulsive effect of Dopamine (10 μM) in isolated corticohippocampal formation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ecopipam (10, mg/kg, oral administration) antagonizes Apomorphine-induced stereotypy in rats^[4].
Ecopipam (5 and 10 μM, perfusion, 1 μL/min) reversibly and dose-dependently decreases acetylcholine release in the rat striatum^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male young adult Long-Evans rats were injected with Nicotine^[3]
Dosage:	0.003, 0.01, 0.03, 0.1, 0.3 mg/kg
Administration:	A single s.c. 20 min before Nicotine (0.1 mg/kg)
Result:	Dose-dependently reduced pressing on both active and inactive levers.

Ensayo clínico

Peso molecular

394.73

Fòrmula

C₁₉H₂₁BrClNO

No. CAS

2587360-22-1

Appearance

Solid

Color

White to off-white

SMILES

CN1[C@]2([H])[C@@](C3=CC=CC=C3CC2)([H])C4=CC(O)=C(Cl)C=C4CC1.Br

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Pureza y Documentación

Purity: 99.0%

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Ficha de datos (281 KB) SDS (252 KB)

COA (261 KB) Elemental Analysis Report (118 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Wu WL, et al. Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists. J Med Chem. 2005 Feb 10;48(3):680-93. [Content Brief]

[2]. Sharopov S, et al. Dopaminergic modulation of low-Mg²⁺-induced epileptiform activity in the intact hippocampus of the newborn mouse in vitro. J Neurosci Res. 2012 Oct;90(10):2020-33. [Content Brief]

[3]. Satanove DJ, et al. Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects. Psychopharmacology (Berl). 2021 Feb;238(2):475-486. [Content Brief]

[4]. R E Chipkin, et al. Pharmacological profile of SCH39166: a dopamine D1 selective benzonaphthazepine with potential antipsychotic activity. J Pharmacol Exp Ther. 1988 Dec;247(3):1093-102. [Content Brief]

[5]. E Acquas, et al. Local application of SCH 39166 reversibly and dose-dependently decreases acetylcholine release in the rat striatum. Eur J Pharmacol. 1999 Nov 3;383(3):275-9. [Content Brief]

Ecopipam hydrobromide Related Classifications

Neurological Disease Metabolic Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ecopipam2587360-22-1SCH 39166SCH39166SCH-39166Dopamine Receptor5-HT ReceptorAdrenergic ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorBeta ReceptorSchizophreniaadditionobesityInhibitorinhibitorinhibit

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Ecopipam hydrobromide (Synonyms: SCH 39166 hydrobromide)

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Other Forms of Ecopipam hydrobromide:

Ecopipam hydrobromide Related Antibodies

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Dopamine Receptor:

Ver todos los productos específicos de isoformas 5-HT Receptor:

Ver todos los productos específicos de isoformas Adrenergic Receptor:

Actividad biológica

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Ecopipam hydrobromide Related Antibodies

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