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Results for "

3ME

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (3) Amino Acid Derivatives (3) Amyloid-β (1) Apoptosis (3) Biochemical Assay Reagents (1) DNA/RNA Synthesis (2) Fluorescent Dye (5) Glycoprotein VI (1) Glycosidase (1) Histamine Receptor (1) Histone Demethylase (10) Histone Methyltransferase (4) Phosphoramidites (1) PROTAC Linkers (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (1) Inflammation/Immunology (2) Neurological Disease (1)
Click Chemistry:	ADC Synthesis (2) Labeling and Fluorescence Imaging (2) Tetrazine (4)
Oligonucleotides:	Phosphoramidites (1) Guanine (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15648B

GSK-J4 Maximum Cited Publications 55 Publications Verification	Histone Demethylase Apoptosis	Cancer
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases *JMJD3/KDM6B* and UTX/KDM6A with IC₅₀s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC₅₀ of 9 μM. GSK J4 is a cell permeable proagent of GSK-J1 ^[3]. GSK-J4 induces endoplasmic reticulum stress-related apoptosis .

HY-15648F

GSK-J4 hydrochloride Maximum Cited Publications 55 Publications Verification	Histone Demethylase	Cancer
GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases *JMJD3/KDM6B* and UTX/KDM6A with IC₅₀s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC₅₀ of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1 ^[3].

HY-15648

GSK-J1 15+ Cited Publications	Histone Demethylase	Cancer
GSK-J1, a chemical probe, is a potent inhibitor of **H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC₅₀** of 60 nM towards KDM6B.

HY-15648A

GSK-J2 4 Publications Verification	Histone Demethylase	Cancer
GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.

HY-W111226

*Fmoc-His(3-Me)-OH*	Amyloid-β Amino Acid Derivatives	Cardiovascular Disease Neurological Disease
Fmoc-His (3-Me)-OH is a histidine derivative with a methylated imidazole group. Fmoc-His (3-Me)-OH can be used for the synthesis of the chemically modified tripeptide His (3-methyl)-Arg-Trp (H (3-Me)-RW). Fmoc-His (3-Me)-OH serves as a resin in Fmoc solid-phase synthesis for the generation of the His-(3-Me)-Gly-Lys peptide. Fmoc-His (3-Me)-OH is a building block for the synthesis of NAHIS02-(p-Met). Fmoc-His (3-Me)-OH can be applied in research related to Alzheimer's disease ^[3].

HY-D1365

Sulfo-Cy3(Me)COOH	Fluorescent Dye	Others
Sulfo-Cy3(Me)COOH is a sulfo-Cyanine3 derivative. Cyanine3 is an orange-fluorescent label dye for protein and nucleic acid (Ex=554 nm, Em=568 nm) .

HY-15648D

GSK-J1 lithium salt 15+ Cited Publications	Histone Demethylase	Cancer
GSK-J1 lithium salt is a potent inhibitor of **H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC₅₀** of 60 nM towards KDM6B.

HY-N8587

*Kadsuric acid 3-Me* ester**	Others	Others
Kadsuric acid 3-Me ester is a Triterpenoids product that can be isolated from the herbs of Kadsura longipedunculata Finet.et Gagnep .

HY-128579

DW14800	Histone Methyltransferase	Cancer
DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC₅₀ of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity .

HY-120766

NCDM-32B	Histone Demethylase	Cancer
NCDM-32B is a potent and selective KDM4 inhibitor, with IC₅₀ values of 3.0 μM for KDM4A and 1.0 μM for KDM4C in in vitro enzyme assays. NCDM-32B specifically increases global *H3K9me3/me2* levels in basal breast cancer cells. NCDM-32B impairs the viability of KDM4C-amplified basal breast cancer cell lines (HCC1954 and Colo824). NCDM-32B can be used for the study of breast cancer .

HY-W013152

*Fmoc-Phe(3-Me)-OH*	Amino Acid Derivatives	Others
Fmoc-Phe(3-Me)-OH is a Fmoc-protected phenylalanine derivative .

HY-157248

*Fmoc-3-Me-Glu(OtBu)-OH*	Amino Acid Derivatives	Others
Fmoc-3-Me-Glu(OtBu)-OH is an amino acid derivative with a protective group .

HY-156307

Me-Tet-PEG3-Maleimide	ADC Linker	Cancer
Me-Tet-PEG3-Maleimide is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-164144

EPZ033294	Histone Methyltransferase	Cancer
EPZ033294 is an inhibitor of SYMD2 (IC₅₀ is 3.9 nM). SYMD2 itself has catalytic activity and can methylate the lysine residue of BTF3 to BTF3me1, which was experimentally demonstrated by detecting an IC₅₀ of 2.9 nM for inhibition of BTF3ME1 by SYMD2, indicating an active inhibition of SYMD2 by EPZ033294. EPZ033294 (0-50 µM) has an inhibitory effect on SYMD2 and a concentration-dependent inhibitory effect in 293T .

HY-164456

AMI-408	Histone Methyltransferase	Cancer
AMI-408 is a PRMT1 inhibitor. AMI-408 can reduce H4R3me2as level in MLL-GAS7 leukemia cells .

HY-15648FR

GSK-J4 hydrochloride (Standard)	Histone Demethylase	Cancer
GSK-J4 (hydrochloride) (Standard) is the analytical standard of GSK-J4 (hydrochloride). This product is intended for research and analytical applications. GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1 ^[3].

HY-15648BR

GSK-J4 (Standard)	Histone Demethylase Apoptosis	Cancer
GSK-J4 (Standard) is the analytical standard of GSK-J4. This product is intended for research and analytical applications. GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable proagent of GSK-J1 ^[3]. GSK-J4 induces endoplasmic reticulum stress-related apoptosis .

HY-175821

PRMT1-IN-3	Histone Methyltransferase Apoptosis	Cancer
PRMT1-IN-3 is a potent protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 4.11 μM. PRMT1-IN-3 inhibits PRMT6 and PRMT8 with IC₅₀s of 23.3 and 30.1 μM. PRMT1-IN-3 suppresses asymmetric dimethylarginine (ADMA) levels and histone *H4R3me2a* modification in triple-negative breast cancer (TNBC) cells. PRMT1-IN-3 induces cell cycle arrest, apoptosis, and inhibits migration and colony formation in MDA-MB-231 cells. PRMT1-IN-3 acts as chemotherapeutic sensitizers for Paclitaxel (HY-B0015). PRMT1-IN-3 can be used for the study of TNBC .

HY-N9051

*6-Prenylquercetin-3-Me* ether**	Glycosidase	Inflammation/Immunology Cancer
6-Prenylquercetin-3-Me ether is a natural product that can be extracted from G. uralensis leaves. 6-Prenylquercetin-3-Me ether has radical scavenging activity toward DPPH. 6-Prenylquercetin-3-Me ether also has inhibitory activity against α-glucosidase .

HY-158662

3-Me-5-OMe-UTP sodium	Biochemical Assay Reagents DNA/RNA Synthesis	Others
3-Me-5-OMe-UTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .

HY-156495

Biotin-PEG3-Me-Tet	ADC Linker	Cancer
Biotin-PEG3-Me-Tet is an ADC Linker containing 3 PEG units. Biotin-PEG3-Me-Tet can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-D2118

TAMRA-PEG3-Me-Tet	Fluorescent Dye	Others
TAMRA-PEG3-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-W748361

Sulfo-Cy3(Me)COOH sodium	Fluorescent Dye	Others
Sulfo-Cy3(Me)COOH sodium is a derivative of Cy3 (Cyanine3) (HY-D0822) dye containing sulfonate ions. Trisulfo-Cy3-acid disodium contains sulfonate ions and has improved water solubility.

HY-D1365A

Sulfo-Cy3(Me)COOH TEA	Fluorescent Dye	Others
Sulfo-Cy3(Me)COOH TEA is a sulfo-Cyanine3 derivative. Cyanine3 is an orange-fluorescent label dye for protein and nucleic acid (Ex=554 nm, Em=568 nm) .

HY-D1365B

Sulfo-Cy3(Me)COOH potassium	Fluorescent Dye	Others
Sulfo-Cyanine 3 free acid potassium is a sulfo-Cyanine3 derivative. Cyanine3 is an orange-fluorescent label dye for protein and nucleic acid (Ex=554 nm, Em=568 nm) .

HY-156479

Me-Tet-PEG3-NHBoc	ADC Linker	Cancer
Me-Tet-PEG3-NHBoc is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-15648G

GSK-J1 sodium	Histone Demethylase	Cancer
GSK-J1 sodium is a potent inhibitor of **H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC₅₀** value of 60 nM towards KDM6B ^[3].

HY-140577

N-Me-N-bis-PEG3	PROTAC Linkers	Cancer
N-Me-N-bis-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-15648I

GSK-J2 sodium	Histone Demethylase	Cancer
GSK-J2 sodium is the sodium form of GSK-J2 (HY-15648A). GSK-J2 is an isomer of GSK-J1, and does not have any specific activity. GSK-J1 (HY-15648) is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A .

HY-P11618

10P3Me	Glycoprotein VI	Cancer
10P3Me is a **Glypican-3 (GPC3)**-targeting probe with a K_a of 93.8 nM for the human target. 10P3Me exhibits high binding affinity to GPC3, targets GPC3-positive cells, and serves as an agent for PET imaging. 10P3Me selectively accumulates in GPC3-positive tumor tissues, including subcutaneous xenograft models and orthotopic HepG2-LUC liver cancer models, to achieve precise localization of lesions .

HY-171338

Gallocatechin-3-O-(3″-O-methyl)-gallate GCG3″Me	Histamine Receptor	Inflammation/Immunology
Gallocatechin-3-O-(3''-O-methyl)-gallate (GCG3''Me) is a catechin polyphenol. Gallocatechin-3-O-(3''-O-methyl)-gallate inhibits histamine release. Gallocatechin-3-O-(3''-O-methyl)-gallate can be used in allergy-related studies .

HY-W714978

*5'-O-DMT-3'-Me-dG(dmf)-CE phosphoramidite*	DNA/RNA Synthesis Phosphoramidites	Others
(2R,3S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((E)-(dimethylamino)methylene)amino)-5-methyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

Cat. No.	Product Name	Type

HY-D1365

Sulfo-Cy3(Me)COOH	Fluorescent Dye
Sulfo-Cy3(Me)COOH is a sulfo-Cyanine3 derivative. Cyanine3 is an orange-fluorescent label dye for protein and nucleic acid (Ex=554 nm, Em=568 nm) .

HY-D2118

TAMRA-PEG3-Me-Tet	Fluorescent Dye
TAMRA-PEG3-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-W748361

Sulfo-Cy3(Me)COOH sodium	Fluorescent Dye
Sulfo-Cy3(Me)COOH sodium is a derivative of Cy3 (Cyanine3) (HY-D0822) dye containing sulfonate ions. Trisulfo-Cy3-acid disodium contains sulfonate ions and has improved water solubility.

HY-D1365A

Sulfo-Cy3(Me)COOH TEA	Fluorescent Dye
Sulfo-Cy3(Me)COOH TEA is a sulfo-Cyanine3 derivative. Cyanine3 is an orange-fluorescent label dye for protein and nucleic acid (Ex=554 nm, Em=568 nm) .

3-Me-5-OMe-UTP sodium	Biochemical Assay Reagents
3-Me-5-OMe-UTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .

Cat. No.	Product Name	Target	Research Area

HY-W111226

*Fmoc-His(3-Me)-OH*	Amyloid-β Amino Acid Derivatives	Cardiovascular Disease Neurological Disease
Fmoc-His (3-Me)-OH is a histidine derivative with a methylated imidazole group. Fmoc-His (3-Me)-OH can be used for the synthesis of the chemically modified tripeptide His (3-methyl)-Arg-Trp (H (3-Me)-RW). Fmoc-His (3-Me)-OH serves as a resin in Fmoc solid-phase synthesis for the generation of the His-(3-Me)-Gly-Lys peptide. Fmoc-His (3-Me)-OH is a building block for the synthesis of NAHIS02-(p-Met). Fmoc-His (3-Me)-OH can be applied in research related to Alzheimer's disease ^[3].

HY-W013152

*Fmoc-Phe(3-Me)-OH*	Amino Acid Derivatives	Others
Fmoc-Phe(3-Me)-OH is a Fmoc-protected phenylalanine derivative .

HY-157248

*Fmoc-3-Me-Glu(OtBu)-OH*	Amino Acid Derivatives	Others
Fmoc-3-Me-Glu(OtBu)-OH is an amino acid derivative with a protective group .

HY-P11618

10P3Me	Glycoprotein VI	Cancer
10P3Me is a **Glypican-3 (GPC3)**-targeting probe with a K_a of 93.8 nM for the human target. 10P3Me exhibits high binding affinity to GPC3, targets GPC3-positive cells, and serves as an agent for PET imaging. 10P3Me selectively accumulates in GPC3-positive tumor tissues, including subcutaneous xenograft models and orthotopic HepG2-LUC liver cancer models, to achieve precise localization of lesions .

*Kadsuric acid 3-Me* ester**	Triterpenes Terpenoids Plants Kadsura longipedunculata Finet et Gagnep. Schisandraceae Source Classification	Others
Kadsuric acid 3-Me ester is a Triterpenoids product that can be isolated from the herbs of Kadsura longipedunculata Finet.et Gagnep .

Cat. No.	Product Name		Classification

HY-156307

Me-Tet-PEG3-Maleimide		ADC Synthesis Tetrazine
Me-Tet-PEG3-Maleimide is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-156495

Biotin-PEG3-Me-Tet		Labeling and Fluorescence Imaging Tetrazine
Biotin-PEG3-Me-Tet is an ADC Linker containing 3 PEG units. Biotin-PEG3-Me-Tet can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-D2118

TAMRA-PEG3-Me-Tet		Labeling and Fluorescence Imaging Tetrazine
TAMRA-PEG3-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-156479

Me-Tet-PEG3-NHBoc		Tetrazine ADC Synthesis
Me-Tet-PEG3-NHBoc is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

Cat. No.	Product Name		Classification

HY-W714978

*5'-O-DMT-3'-Me-dG(dmf)-CE phosphoramidite*		Phosphoramidites Guanine
(2R,3S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((E)-(dimethylamino)methylene)amino)-5-methyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

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3ME

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Click Chemistry

Oligonucleotides

Natural
Products