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Amino Acid Oxidase

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製品番号 製品名 Target 研究分野 構造式
  • HY-N0305
    5-Aminolevulinic acid hydrochloride
    Maximum Cited Publications
    20 Publications Verification

    5-ALA hydrochloride; δ-Aminolevulinic Acid hydrochloride; 5-Amino-4-oxopentanoic Acid hydrochloride

    Reactive Oxygen Species (ROS) Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    5-Aminolevulinic acid (5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid) hydrochloride is an orally active heme precursor. 5-Aminolevulinic acid hydrochloride promotes aerobic energy metabolism and increases ATP levels by enhancing the activity of cytochrome c oxidase. 5-Aminolevulinic acid hydrochloride enhances LPS-induced proinflammatory cytokine production and gene activation, and restores the phagocytic activity and ROS generation capacity of neutrophils. 5-Aminolevulinic acid hydrochloride selectively accumulates protoporphyrin IX in tumor cells; as a photosensitizer and radiosensitizer, it induces ROS burst upon light or X-ray irradiation to inhibit tumor growth. 5-Aminolevulinic acid hydrochloride can be applied to the research of septic shock, melanoma, and cancer radiotherapy .
    5-Aminolevulinic acid hydrochloride
  • HY-W000450
    5-Aminolevulinic acid
    Maximum Cited Publications
    20 Publications Verification

    5-ALA; δ-Aminolevulinic Acid; 5-Amino-4-oxopentanoic Acid

    Reactive Oxygen Species (ROS) Cardiovascular Disease Cancer
    5-Aminolevulinic acid (5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid) is an orally active heme precursor. 5-Aminolevulinic acid promotes aerobic energy metabolism and increases ATP levels by enhancing the activity of cytochrome c oxidase. 5-Aminolevulinic acid enhances LPS-induced proinflammatory cytokine production and gene activation, and restores the phagocytic activity and ROS generation capacity of neutrophils. 5-Aminolevulinic acid selectively accumulates protoporphyrin IX in tumor cells; as a photosensitizer and radiosensitizer, it induces ROS burst upon light or X-ray irradiation to inhibit tumor growth. 5-Aminolevulinic acid can be applied to the research of septic shock, melanoma, and cancer radiotherapy .
    5-Aminolevulinic acid
  • HY-W014502

    Aryl Hydrocarbon Receptor Endogenous Metabolite Cancer
    D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR) .
    D-Kynurenine
  • HY-W012669

    Phthaldialdehyde

    Environmental Pollutants Biochemical Assay Reagents Infection
    Phthalaldehyde (Phthaldialdehyde) reacts with proteins containing primary amines and blocked amino-terminal peptides of amino acids. Phthalaldehyde stabilizes bacterial outer membranes and cell walls, increases the optical density of bacterial cell suspensions, and inhibits bacterial lysis induced by ethylenediaminetetraacetic acid and sodium dodecyl sulfate. Phthalaldehyde exhibits bactericidal activity against Gram-negative vegetative bacteria .
    Phthalaldehyde
  • HY-B1018A
    Phenelzine sulfate
    5+ Cited Publications

    Monoamine Oxidase GABA Receptor Histone Demethylase Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .
    Phenelzine sulfate
  • HY-Y0127
    D(-)-2-Aminobutyric acid
    1 Publications Verification

    Endogenous Metabolite Others
    D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.
    D(-)-2-Aminobutyric acid
  • HY-116688

    Amino Acid Derivatives Others
    2-Hydroxy-4-(methylthio)butyric acid (2-Hydroxy-4-(Methylthio)-Butanoic Acid) is an orally active source of methionine. 2-Hydroxy-4-(methylthio)butyric acid reduces the expression of multiple mRNAs (BHMT, MTR, MAT1A, SAHH, and PCK1). 2-Hydroxy-4-(methylthio)butyric acid increases milk production in periparturient cows .
    2-Hydroxy-4-(methylthio)butyric acid
  • HY-P2986

    Endogenous Metabolite Amino Acid Oxidase Metabolic Disease
    D-Amino acid oxidase is an enzyme to metabolize exogenous D-amino acids in animals for detoxifying action. D-Amino acid oxidase also modulates the level of D-serine in brain .
    D-Amino acid oxidase (Immobilized)
  • HY-P2987

    Endogenous Metabolite Amino Acid Oxidase Metabolic Disease
    L-Amino acid oxidase is a homodimeric proteins containing flavin adenine dinucleotide. L-Amino acid oxidase can catalyze the stereospecific oxidative deamination of L-amino acids to α-keto acids and ammonia .
    L-Amino acid oxidase
  • HY-109183

    TAK-831

    Xanthine Oxidase Others
    Luvadaxistat (TAK-831) is an orally active, highly selective, potent D-amino acid oxidase (DAAO) inhibitor. Luvadaxistat inhibits oxidative deamination of D-serine via the human recombinant DAAO enzyme with an IC50 of 14 nM. Luvadaxistat significantly increases D-serine levels in the rodent brain, plasma, and cerebrospinal fluid. Luvadaxistat has the potential for schizophrenia research .
    Luvadaxistat
  • HY-W037417

    Xanthine Oxidase Others
    DAO-IN-1 is a potent inhibitor of D-amino acid oxidase (DAO) with an IC50 value of 269 nM. DAO is an enzyme responsible for D-serine metabolism, D-serine is a co-agonist of NMDA receptors .
    DAO-IN-1
  • HY-W001959

    Endogenous Metabolite Metabolic Disease
    D-Allothreonine is the D stereoisomer of Allothreonine. D-Allallreonine is a peptide lipid derived from bacteria. D-Allothreonine can be specifically oxidized by D-amino acid oxidase, while the L configuration has no reaction. D-Allallreonine is also a component of bacterial polysaccharides. D-Allallreonine can be used for researching bacterial pathogenicity, antigenic diversity and drug resistance .
    D-Allothreonine
  • HY-117292
    DAO-IN-2
    1 Publications Verification

    Amino Acid Oxidase Neurological Disease
    DAO-IN-2 is a d-amino acid oxidase (DAO) inhibitor (h-DAO IC50 = 245 nM). DAO-IN-2 is a moderate inhibitor of DAAO in vitro and in vivo. DAO-IN-2 can be used to study DAAO-related psychiatric disorders .
    DAO-IN-2
  • HY-E70082

    Biochemical Assay Reagents Metabolic Disease
    Fructosyl amino acid oxidase can be used to measure glycosylated protein. Glycosylated protein, especially glycosylated hemoglobin A1c, is an important marker to evaluate the efficacy of diabetes treatment .
    Fructosyl amino acid oxidase
  • HY-111412

    iGluR Neurological Disease
    DAAO inhibitor-1 is a potent D-amino acid oxidase (DAAO) inhibitor with an IC50 of 0.12 μM.
    DAAO inhibitor-1
  • HY-Y0127S

    Isotope-Labeled Compounds Endogenous Metabolite Others
    D(-)-2-Aminobutyric acid-d6 is the deuterium labeled D(-)-2-Aminobutyric acid. D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.
    D(-)-2-Aminobutyric acid-d6
  • HY-Y0607S1

    Isotope-Labeled Compounds Drug Intermediate Others
    4-Nitrobenzoic acid-d2 is the deuterium labeled 4-Nitrobenzoic acid (HY-Y0607). 4-Nitrobenzoic acid acts as a redox mediator and electron transfer promoter. 4-Nitrobenzoic acid accepts electrons from reduced glucose oxidase and transfers them to the electrode to facilitate the glucose oxidation reaction, while minimizing the formation of protonated amino groups .
    4-Nitrobenzoic acid-d2
  • HY-P2965

    Endogenous Metabolite Cancer
    L-Lysine α-oxidase is a potent anticancer agent. L-Lysine α-oxidase also a L-amino acid oxidase, deaminates L-lysine with the yield of H2O2, ammonia, and α-keto-ε-aminocaproate. L-Lysine α-oxidase shows cytotoxicity and anticancer activity .
    L-Lysine α-oxidase
  • HY-19844

    Drug Derivative Aldehyde Oxidase (AO) Infection
    ANA975, 5-amino-3-β -D-ribofuranosyl-3H-thiazolo[4,5-d]pyrimidin-2-one derivative, is an oral prodrug of the TLR-7 agonist Isatoribine (HY-13655A). ANA975 is converted to Isatoribine via a combined mechanism of hydrolysis by esterases and oxidation by aldehyde oxidase. ANA975 can be used in the research of hepatitis C virus infection .
    ANA-975
  • HY-33009

    Amino Acid Oxidase Neurological Disease
    AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic D-amino acid oxidase (DAAO) inhibitor with an IC50 value of 0.91 μM and EC50 of 2.2-3.95 μM. AS057278 can normalize phencyclidine (PCP)-induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia .
    AS057278
  • HY-W026426

    Amino Acid Oxidase Inflammation/Immunology
    4,5,6,7-Tetrahydro-1,2-benzoxazole-3-carboxylic acid (Compound 244) is an indole compound. 4,5,6,7-Tetrahydro-1,2-benzoxazole-3-carboxylic acid does not inhibit COX-2 and shows the inhibition rate <1% against d-amino acid oxidase (DAO) at 10 μM .
    4,5,6,7-Tetrahydro-1,2-benzoxazole-3-carboxylic acid
  • HY-W014502R

    Reference Standards Aryl Hydrocarbon Receptor Endogenous Metabolite Cancer
    D-Kynurenine (Standard) is the analytical standard of D-Kynurenine. This product is intended for research and analytical applications. D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR) .
    D-Kynurenine (Standard)
  • HY-W039920

    β-D-Galactosylamine, 98%

    Biochemical Assay Reagents Others
    1-Amino-1-deoxy-β-D-galactose, 98% is a galactose analog used as a competitive inhibitor to aid in the separation, purification, identification, differentiation, and characterization of β-D-galactosidase and galactose oxidase.
    1-Amino-1-deoxy-β-D-galactose, 98%
  • HY-N14924

    Bacterial Infection
    Oganomycin GA is Streptomyces str. oganonensis Y-G 19Z and Oganomycin A is produced when p-hydroxycinnamate sodium salt is added to the fermentation medium. Under the action of D-amino acid oxidase, A generates glutaryl derivative, GA; A and GA were converted to B and GB by acid hydrolysis to remove sulfate esters. The effect of B on d-amino acid oxidase was also changed to GB. A and B were more stable than A and B of cemycin, and had stronger effect against Gram-positive and Gram-negative bacteria than Gram-positive bacteria .
    Oganomycin GA
  • HY-Y0127R

    Reference Standards Endogenous Metabolite Others
    D(-)-2-Aminobutyric acid (Standard) is the analytical standard of D(-)-2-Aminobutyric acid. This product is intended for research and analytical applications. D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.
    D(-)-2-Aminobutyric acid (Standard)
  • HY-117292R

    Reference Standards Amino Acid Oxidase Neurological Disease
    DAO-IN-2 (Standard) is the analytical standard of DAO-IN-2 (HY-117292). This product is intended for research and analytical applications. DAO-IN-2 is a novel D-amino acid oxidase (DAO) inhibitor. DAO-IN-2 demonstrates moderate potency for DAO in vitro and ex vivo .
    DAO-IN-2 (Standard)
  • HY-E70082A

    Biochemical Assay Reagents Others
    Fructosyl-Amino Acid Oxidase, Corynebacterium sp. catalyzes the oxidative deglycation of low molecular weight fructosamines. Fructosyl-Amino Acid Oxidase, Corynebacterium sp. catalyzes the oxidation of the C-N bond linking the C1 of the fructosyl moiety and the nitrogen of the amino group of fructosyl amino acids.
    Fructosyl-Amino Acid Oxidase, Corynebacterium sp.
  • HY-W001959R

    Reference Standards Endogenous Metabolite Metabolic Disease
    D-Allothreonine (Standard) is an analytical standard for D-Allothreonine (HY-001959). This product is intended for research and analytical applications. D-Allothreonine is the D-stereoisomer of allothreonine. D-Allothreonine is a bacterial peptide lipid. D-Allothreonine is specifically oxidized by D-amino acid oxidase, while the L-form is unresponsive. D-Allothreonine is also a component of bacterial polysaccharides. D-Allothreonine can be used to study bacterial pathogenicity, antigenic diversity, and drug resistance.
    D-Allothreonine (Standard)
  • HY-P2986A

    Endogenous Metabolite Metabolic Disease
    D-Amino Acid Oxidase, Porcine (EC 1.4.3.3) is used in the measurement of D-alanine and FAD, and in the preparation of L-amino acids from racemic mixtures.
    D-Amino Acid Oxidase, Porcine
  • HY-P2986B

    Endogenous Metabolite Metabolic Disease
    Apo D-Amino Acid Oxidase, Porcine (EC 1.4.3.3) is entirely present as a monomeric protein.
    Apo D-Amino Acid Oxidase, Porcine
  • HY-P2986C

    D-Amino Acid Oxidase, Human
  • HY-E70926

    Endogenous Metabolite Metabolic Disease
    Lysine Oxidase, Trichoderma viride (EC 1.4.3.14), is an oxidoreductase that acts on the CH-NHsub>2 group in the donor molecule and uses oxygen as the acceptor. Lysine Oxidase participates in the degradation of lysine. The three substrates of lysine oxidase are L-lysine, O2, and H2O, while its three products are 6-amino-2-oxohexanoic acid, NH3, and H2O2.
    Lysine Oxidase,Trichoderma viride
  • HY-182727

    Monoamine Oxidase Drug Metabolite Metabolic Disease
    MDL 72392 is a selective irreversible monoamine oxidase A (MAO-A) inhibitor. MDL 72392 inhibits MAO-A. MDL 72392 is formed by decarboxylation of the bioprecursor amino acid MDL 72394 via aromatic L-amino acid decarboxylase. MDL 72392 can be used in melatonin biosynthesis research .
    MDL 72392
  • HY-N14926

    Bacterial Infection
    Oganomycin GB is Streptomyces str. oganonensis Y-G 19Z and Oganomycin A is produced when p-hydroxycinnamate sodium salt is added to the fermentation medium. Under the action of D-amino acid oxidase, A generates glutaryl derivative, GA; A and GA were converted to B and GB by acid hydrolysis to remove sulfate esters. The effect of B on d-amino acid oxidase was also changed to GB. A and B were more stable than A and B of cemycin, and had stronger effect against Gram-positive and Gram-negative bacteria than Gram-positive bacteria. The antibacterial activity of A and B was higher than that of GA and GB .
    Oganomycin GB
  • HY-182000

    Xanthine Oxidase BCRP GLUT Metabolic Disease
    Xanthine oxidase-IN-23 (Compound BPF) is an orally active, reversible, mixed-type Xanthine oxidase inhibitor with an IC50 of 3.33 μM. Xanthine oxidase-IN-23 directly binds to XOD in a reversible mixed-type manner to inhibit its catalytic activity. Xanthine oxidase-IN-23 upregulates ABCG2 and downregulates GLUT9 to promote renal urate excretion. Xanthine oxidase-IN-23 reduces serum urate levels and improves renal function in hyperuricemic mice. Xanthine oxidase-IN-23 can be used in the research of hyperuricemia .
    Xanthine oxidase-IN-23
  • HY-181141

    Cholinesterase (ChE) Monoamine Oxidase Neurological Disease
    AChE/MAO-B-IN-8 is an acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B) inhibitor with IC50 values of 0.72 and 0.19 μM. AChE/MAO-B-IN-8 interactions with AChE and MAO-B active-site amino acid residues. AChE/MAO-B-IN-8 can be used for the research of Alzheimer’s disease .
    AChE/MAO-B-IN-8
  • HY-33009R

    Others Neurological Disease
    AS057278 (Standard) is the analytical standard of AS057278. This product is intended for research and analytical applications. AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic D-amino acid oxidase (DAAO) inhibitor with an IC50 value of 0.91 μM and EC50 of 2.2-3.95 μM. AS057278 can normalize phencyclidine (PCP)-induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia .
    AS057278 (Standard)

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