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Phthalaldehyde  (Synonyms: Phthaldialdehyde)

Cat. No.: HY-W012669 Purity: 99.80%
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Handling Instructions Technical Support

Phthalaldehyde reacts with proteins containing primary amines and blocked amino-terminal peptides of amino acids. Phthalaldehyde stabilizes bacterial outer membranes and cell walls, increases the optical density of bacterial cell suspensions, and inhibits bacterial lysis induced by ethylenediaminetetraacetic acid and sodium dodecyl sulfate. Phthalaldehyde exhibits bactericidal activity against Gram-negative vegetative bacteria.

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Phthalaldehyde

Phthalaldehyde Chemical Structure

CAS No. : 643-79-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
25 g In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Phthalaldehyde:

Phthalaldehyde Related Antibodies

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Description

Phthalaldehyde reacts with proteins containing primary amines and blocked amino-terminal peptides of amino acids. Phthalaldehyde stabilizes bacterial outer membranes and cell walls, increases the optical density of bacterial cell suspensions, and inhibits bacterial lysis induced by ethylenediaminetetraacetic acid and sodium dodecyl sulfate. Phthalaldehyde exhibits bactericidal activity against Gram-negative vegetative bacteria[1][2].

In Vitro

Phthalaldehyde (0.0025% (w/v); 1-180 min) reacts with lysine, glycine, and histidine to produce distinct UV absorption peaks at both acidic and alkaline pH, with reaction rates accelerating at higher pH; specific peak patterns and development times vary by amino acid[1].
Phthalaldehyde (0.05-0.2% (w/v); 2 h at 20 °C) induces dark color changes in pellets of Gram-negative (E. coli, P. aeruginosa) and Gram-positive (S. aureus) bacteria, with darker colors observed at alkaline pH and higher OPA concentration[1].
Phthalaldehyde (0.1% (w/v); 30 min at 20 °C) significantly inhibits EDTA-Tris induced lysis of Pseudomonas aeruginosa PA01[1].
Phthalaldehyde (0.1% (w/v); 30 min at 20 °C) significantly inhibits lysostaphin-induced lysis of Staphylococcus aureus NCTC 6571, with efficacy comparable to glutaraldehyde[1].
Phthalaldehyde (0.25-0.5% (w/v); 60 min) significantly increases the absorbance of Escherichia coli ATCC 9481, Staphylococcus aureus NCTC 6571, and Pseudomonas aeruginosa PA01 suspensions, with a greater increase in E. coli absorbance observed at the 0.5% (w/v) concentration[1].
Phthalaldehyde detects the blocked amino-terminal tryptic peptide of rat liver acyl-CoA oxidase by forming a fluorescent Schiff base with the peptide's free α-amino group[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phthalaldehyde Related Antibodies
Molecular Weight

134.13

Formula

C8H6O2
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

O=CC1=CC=CC=C1C=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (1491.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.4555 mL 37.2773 mL 74.5545 mL
5 mM 1.4911 mL 7.4555 mL 14.9109 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.81%

SDS (786 KB)

COA (255 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.4555 mL 37.2773 mL 74.5545 mL 186.3863 mL
5 mM 1.4911 mL 7.4555 mL 14.9109 mL 37.2773 mL
10 mM 0.7455 mL 3.7277 mL 7.4555 mL 18.6386 mL
15 mM 0.4970 mL 2.4852 mL 4.9703 mL 12.4258 mL
20 mM 0.3728 mL 1.8639 mL 3.7277 mL 9.3193 mL
25 mM 0.2982 mL 1.4911 mL 2.9822 mL 7.4555 mL
30 mM 0.2485 mL 1.2426 mL 2.4852 mL 6.2129 mL
40 mM 0.1864 mL 0.9319 mL 1.8639 mL 4.6597 mL
50 mM 0.1491 mL 0.7455 mL 1.4911 mL 3.7277 mL
60 mM 0.1243 mL 0.6213 mL 1.2426 mL 3.1064 mL
80 mM 0.0932 mL 0.4660 mL 0.9319 mL 2.3298 mL
100 mM 0.0746 mL 0.3728 mL 0.7455 mL 1.8639 mL
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Phthalaldehyde Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phthalaldehyde643-79-8PhthaldialdehydeBiochemical Assay ReagentsEnvironmental PollutantsEnvironmental Contaminantsprimary amine-containing proteinsEscherichia coli ATCC 9481Gram-negative vegetative bacteriabacterial outer membranesPseudomonas aeruginosa PA01amino acidsrat liver acyl-CoA oxidaserat acyl-CoA oxidasebacterial cell wallsStaphylococcus aureus NCTC 6571Inhibitorinhibitorinhibit

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