CKI

By Targets:	5-HT Receptor (2) Apoptosis (1) Casein Kinase (7) CDK (2) Drug Metabolite (2) FLT3 (1) HCN Channel (2) Isotope-Labeled Compounds (1) Ribosomal S6 Kinase (RSK) (2) Serotonin Transporter (2) SGK (2) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (6) Inflammation/Immunology (1) Neurological Disease (5)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W011109

CKI-7 1 Publications Verification	Casein Kinase CDK SGK Ribosomal S6 Kinase (RSK)	Cancer
CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC₅₀ of 6 μM and a K_i of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases .

HY-W052508

Norquetiapine 1 Publications Verification N-Desalkylquetiapine	Drug Metabolite 5-HT Receptor HCN Channel Serotonin Transporter	Neurological Disease
Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), *5-HT_2C(K_i* = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation .

HY-12774

IC261 4 Publications Verification	Casein Kinase Apoptosis	Cancer
IC261 is a selective, ATP-competitive CK1 inhibitor, with IC₅₀s of 1 μM, 1 μM, 16 μM for Ckiδ, Ckiε and Ckiα1, respectively.

HY-133028

CKI-7 free base 1 Publications Verification	Casein Kinase CDK SGK Ribosomal S6 Kinase (RSK)	Cancer
CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC₅₀ of 6 μM and a K_i of 8.5 μM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 free base has a much weaker effect on casein kinase II and other protein kinases .

HY-15704

LH846 2 Publications Verification	Casein Kinase	Cancer
LH846 is a selective inhibitor of CKIδ, with an IC₅₀ of 290 nM, and less potently inhibits CKIα and CKIε, with IC₅₀s of 2.5 μM and 1.3 μM, respectively.

HY-120084

BTX161 1 Publications Verification	Casein Kinase	Cancer
BTX161, a thalidomide analog, is an effective CKIα degrader. BTX161 mediates human AML cell CKIα degradation more effectively than lenalidomide and activates the DNA damage response (DDR) and p53, while stabilizing p53 antagonist MDM2.

HY-128677

NCC007	Casein Kinase	Neurological Disease
NCC007 is a dual *casein kinase Iα (CKIα)* and *δ (CKIδ)* inhibitor with IC₅₀s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms .

HY-15490A

PF-670462	Casein Kinase	Neurological Disease
PF-670462 is a selective CKI ε/δ inhibitor. PF-670462 effectively regulates the phase of the circadian rhythm .

HY-155195

FLT3/CHK1-IN-1	FLT3	Cancer
FLT3/CHK-IN-1 (Compound 18) is a dual inhibitor of FLT3/CHK1. FLT3/CHK-IN-1 is more than 1700 times more selective to c-KI T and greatly reduces hERG affinity with an IC₅₀ value of 58.4 μM. FLT3/CHK-IN-1 inhibits tumor growth in mouse xenotransplantation models inoculated with MV-4-11 cells .

HY-W052508S

Norquetiapine-d8 N-Desalkylquetiapine-d₈	Isotope-Labeled Compounds	Others Neurological Disease Inflammation/Immunology
Norquetiapine-d8 (N-Desalkylquetiapine-d8) is the deuterium labeled Norquetiapine.Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), *5-HT_2C(K_i* = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation .

HY-RS02633

CHKA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CHKA Human Pre-designed siRNA Set A contains three designed siRNAs for CHKA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CHKA Human Pre-designed siRNA Set A CHKA Human Pre-designed siRNA Set A

HY-W040555

Norquetiapine dihydrochloride 1 Publications Verification N-Desalkylquetiapine dihydrochloride	Drug Metabolite 5-HT Receptor HCN Channel Serotonin Transporter	Neurological Disease
Norquetiapine ( N-Desalkylauetiapine) dihydrochloride, a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine dihydrochloride selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), *5-HT_2C(K_i* = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine dihydrochloride blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine dihydrochloride shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine dihydrochloride can be used for the study of depression and inflammation .

Species:	Human (11)
Tag:	His (5) Strep (1) Tag Free (2) GST (5)
Source:	sf9 insect cells (1) Sf9 insect cells (8) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702669

	CSNK1G1 Protein, Human (Active, sf9, GST) Casein kinase I isoform gamma-1; CKI-gamma 1	Human	Sf9 insect cells
	The CSNK1G1 protein is a member of the casein kinase family that preferentially phosphorylates acidic proteins, including casein, exhibiting broad substrate specificity. Functionally, it actively participates in the Wnt signaling pathway and regulates cellular responses. CSNK1G1 Protein, Human (sf9, GST) is the recombinant human-derived CSNK1G1, expressed by Sf9 insect cells, with GST labeled tag. The total length of CSNK1G1 Protein, Human (sf9, GST) is 421 a.a..

HY-P76850

	CSNK1G1 Protein, Human (Active, sf9, His-GST) Casein kinase I isoform gamma-1; CKI-gamma 1	Human	Sf9 insect cells
	The CSNK1G1 protein is a member of the casein kinase family that preferentially phosphorylates acidic proteins, including casein, exhibiting broad substrate specificity. Functionally, it actively participates in the Wnt signaling pathway and regulates cellular responses. CSNK1G1 Protein, Human (sf9, His-GST) is the recombinant human-derived CSNK1G1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P701659

	CK1γ3 Protein, Human (Active, sf9) CSNK1G3; Casein kinase I isoform gamma-3; CKI-gamma 3	Human	Sf9 insect cells
	The CK1γ3 protein is a serine/threonine protein kinase in the casein kinase family that prefers acidic proteins, including casein. It has broad substrate specificity and can phosphorylate a variety of proteins, affecting diverse cellular processes. CK1γ3 Protein, Human (sf9) is the recombinant human-derived CK1γ3 protein, expressed by sf9 insect cells , with tag free.

HY-P701660

	CK1γ3 Protein, Human (Active, sf9, GST) CSNK1G3; Casein kinase I isoform gamma-3; CKI-gamma 3	Human	Sf9 insect cells
	The CK1γ3 protein is a serine/threonine protein kinase in the casein kinase family that prefers acidic proteins, including casein. It has broad substrate specificity and can phosphorylate a variety of proteins, affecting diverse cellular processes. CK1γ3 Protein, Human (sf9, GST) is the recombinant human-derived CK1γ3 protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P72873

	Casein Kinase I gamma-2/CSNK1G2 Protein, Human (Active, sf9, His) Casein kinase I isoform gamma-2; CKI-gamma 2; CSNK1G2; CK1G2	Human	Sf9 insect cells
	Casein kinase I gamma-2 is a serine/threonine protein kinase that targets acidic proteins and phosphorylates a variety of substrates, such as COL4A3BP/CERT, MTA1 and SMAD3, especially destabilizing SMAD3 and inhibiting TGF- beta reaction. Hyperphosphorylation of COL4A3BP/CERT disrupts ER-to-Golgi transport and affects the synthesis of ceramide and sphingomyelin. Casein Kinase I gamma-2/CSNK1G2 Protein, Human (sf9, His) is the recombinant human-derived Casein Kinase I gamma-2 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P705484

	CK1d Protein, Human (His) CSNK1D; Casein kinase I isoform delta; CKI-delta; CKId; Tau-protein kinase CSNK1D	Human	E. coli

HY-P701658

	CK1d Protein, Human (Active, sf9, GST) CSNK1D; Casein kinase I isoform delta; CKI-delta; CKId; Tau-protein kinase CSNK1D	Human	Sf9 insect cells
	The CK1d protein is an important serine/threonine protein kinase that complexly controls cellular processes such as Wnt signaling, DNA repair, and circadian rhythms. Its versatility is evident in phosphorylating a variety of proteins, including connexin-43/GJA1, MAP1A, p53/TP53, and YAP1. CK1d Protein, Human (sf9, GST) is the recombinant human-derived CK1d protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P72872

	CSNK1A1/Casein Kinase I alpha Protein, Human (Active, sf9, GST) Casein kinase I isoform alpha; CKI-alpha; CK1; CSNK1A1	Human	Sf9 insect cells
	Casein kinase I α is a member of casein kinases that exhibits a preference for phosphorylation of acidic proteins such as casein. It phosphorylates many substrates, including CTNNB1 at "Ser-45" involved in Wnt signaling. CSNK1A1/Casein Kinase I alpha Protein, Human (sf9, GST) is the recombinant human-derived Casein Kinase I alpha protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P72152

	CSNK1E Protein, Human (Inactive, His) Casein kinase 1 epsilon; Casein kinase I; Casein kinase I epsilon; Casein kinase I isoform epsilon; CKI epsilon; CKI-epsilon; CKIe; CKIepsilon; CSNK 1E; CSNK1E; DBT; Doubletime, Drosophila, homolog of; EC 2.7.11.1; epsilon isoform; HCK IE; KC1E; KC1E_HUMAN; kinase CK1 epsilon; MGC 10398	Human	E. coli
	CSNK1E protein is a casein kinase that preferentially phosphorylates acidic proteins such as casein. CSNK1E Protein, Human (His) is the recombinant human-derived CSNK1E protein, expressed by E. coli , with N-6*His labeled tag.

HY-P705796

	CSNK1E Protein, Human (Active, sf9) Casein kinase 1 epsilon; Casein kinase I; Casein kinase I epsilon; Casein kinase I isoform epsilon; CKI epsilon; CKI-epsilon; CKIe; CKIepsilon; CSNK 1E; CSNK1E; DBT; Doubletime, Drosophila, homolog of; EC 2.7.11.1; epsilon isoform; HCK IE; KC1E; KC1E_HUMAN; kinase CK1 epsilon; MGC 10398	Human	sf9 insect cells

HY-P702668

	CSNK1A1/Casein Kinase I alpha Protein, Human (Active, sf9, His, Strep) CSNK1A1; casein kinase 1, alpha 1; casein kinase I isoform alpha; CK1; CK1a; CK1alpha; CKIa; CKIalpha; clock regulator kinase; CKI-alpha; down-regulated in lung cancer; HLCDGP1; PRO2975	Human	Sf9 insect cells
	Casein kinase I α is a member of casein kinases that exhibits a preference for phosphorylation of acidic proteins such as casein. It phosphorylates many substrates, including CTNNB1 at "Ser-45" involved in Wnt signaling. CSNK1A1/Casein Kinase I alpha Protein, Human (sf9, His, Strep) is the recombinant human-derived CSNK1A1, expressed by Sf9 insect cells, with Strep, His labeled tag.

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HY-W052508S

Norquetiapine-d8
Norquetiapine-d8 (N-Desalkylquetiapine-d8) is the deuterium labeled Norquetiapine.Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), *5-HT_2C(K_i* = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation .

Norquetiapine-d8

Norquetiapine-d8 (N-Desalkylquetiapine-d8) is the deuterium labeled Norquetiapine.Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), 5-HT_2C(K_i = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation .

Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (3) Rat (2)
Application:	IHC-P (1) ICC/IF (1) IP (2) WB (3) ELISA (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80585

	Casein Kinase 1 alpha Antibody (YA564) CSNK1A1; Casein kinase I isoform alpha; CKI-alpha; CK1	WB, IP	Human, Rat
	Casein Kinase 1 alpha Antibody (YA564) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Casein Kinase 1 alpha.

HY-P85075

	Casein Kinase 1 alpha Antibody (YA4767) CSNK1A1; Casein kinase I isoform alpha; CKI-alpha; CK1	WB, IHC-P, ICC/IF, ELISA	Human
	Casein Kinase 1 alpha Antibody (YA4767) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Casein Kinase 1 alpha.

HY-P80585A

	Casein Kinase 1 alpha Antibody (YA564)(PBS only) CSNK1A1; Casein kinase I isoform alpha; CKI-alpha; CK1	WB, IP	Human, Rat
	Casein Kinase 1 alpha Antibody (YA564) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Casein Kinase 1 alpha.

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Cat. No.	Product Name		Classification

HY-RS02633

CHKA Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CHKA Human Pre-designed siRNA Set A contains three designed siRNAs for CHKA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

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