CK1d Protein, Human (Active, sf9, GST)
The CK1d protein is an important serine/threonine protein kinase that complexly controls cellular processes such as Wnt signaling, DNA repair, and circadian rhythms. Its versatility is evident in phosphorylating a variety of proteins, including connexin-43/GJA1, MAP1A, p53/TP53, and YAP1. CK1d Protein, Human (sf9, GST) is the recombinant human-derived CK1d protein, expressed by sf9 insect cells , with N-GST labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The CK1d protein is an important serine/threonine protein kinase that complexly controls cellular processes such as Wnt signaling, DNA repair, and circadian rhythms. Its versatility is evident in phosphorylating a variety of proteins, including connexin-43/GJA1, MAP1A, p53/TP53, and YAP1. CK1d Protein, Human (sf9, GST) is the recombinant human-derived CK1d protein, expressed by sf9 insect cells , with N-GST labeled tag.
Background
CK1d Protein, an essential serine/threonine-protein kinase, intricately regulates cellular growth and survival processes encompassing Wnt signaling, DNA repair, and circadian rhythms. Demonstrating versatility, CK1d phosphorylates a diverse array of proteins, including connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1, and PER2. It plays a central role in the circadian clock, determining the period length through the regulation of PER1 and PER2 phosphorylation. Additionally, CK1d influences the WNT3A signaling pathway, neuronal outgrowth, ubiquitination of YAP1, DNA-binding activity of DNMT1, and numerous other cellular processes. This multifaceted kinase emerges as a key player in coordinating diverse cellular functions and signaling pathways.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-GST
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Accession
P48730 (E2-R415)
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Gene ID1453
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Molecular Construction
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N-term
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GST
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CK1d (E2-R415)
Accession # P48730 -
C-term
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Protein Length
Full Length
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Synonyms
CSNK1D; CKI-Delta; Casein Kinase 1 Delta; Non-Specific Serine/Threonine Protein Kinase; HCKID; Casein Kinase 1, Delta; CKIdelta; Casein Kinase I; CKID; FASPS2; Casein Kinase I Isoform Delta; ASPS; Tau-Protein Kinase CSNK1D; CKId
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AA Sequence
ELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
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Molecular Weight
Approximately 74 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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