1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
  2. Casein Kinase
  3. LH846

LH846 

Cat. No.: HY-15704 Purity: >98.0%
Handling Instructions

LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively.

For research use only. We do not sell to patients.

LH846 Chemical Structure

LH846 Chemical Structure

CAS No. : 639052-78-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 300 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively.

IC50 & Target[1]

CKIδ

290 nM (IC50)

CKIϵ

1.3 μM (IC50)

CKIα

2.5 μM (IC50)

In Vitro

LH846 is a potent inhibitor of CKIδ, with an IC50 of 290 nM, less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively, and has no effect on CK2. LH846 (3 or 10 μM) inhibits CKIδ-dependent phosphorylation of PER1 in HEK293T cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

316.81

Formula

C₁₆H₁₃ClN₂OS

CAS No.

639052-78-1

SMILES

O=C(NC1=NC2=CC(Cl)=C(C)C=C2S1)CC3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 45 mg/mL (142.04 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1565 mL 15.7823 mL 31.5647 mL
5 mM 0.6313 mL 3.1565 mL 6.3129 mL
10 mM 0.3156 mL 1.5782 mL 3.1565 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.89 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

LH846LH 846LH-846Casein KinaseInhibitorinhibitorinhibit

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Product Name:
LH846
Cat. No.:
HY-15704
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