1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
  2. Casein Kinase

LH846 

Cat. No.: HY-15704 Purity: 98.02%
Data Sheet SDS Handling Instructions

LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); displays no inhibitory activity at CK2.

For research use only. We do not sell to patients.
LH846 Chemical Structure

LH846 Chemical Structure

CAS No. : 639052-78-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 77 In-stock
5 mg USD 70 In-stock
10 mg USD 96 In-stock
50 mg USD 300 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); displays no inhibitory activity at CK2. IC50 Value: 290 nM (CK1δ); 1.3 uM (CK1ε); 2.5 uM (CK1α) [1] Target: CK1 LH846 inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. Shown to lengthen the circadian period in U2OS cells, with minimal effect on amplitude. Treatment with LH846 reduced the PER1 mobility shift and PER1 clearance in a dose-dependent manner, indicating that CKIδ-dependent phosphorylation and subsequent degradation of PER1 protein is inhibited by LH846 treatment. Previous genetic studies demonstrated an important role of CKI-dependent phosphorylation of PER protein in period regulation, supporting the period lengthening effect of LH846 through PER1 protein phosphorylation [1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.1565 mL 15.7823 mL 31.5647 mL
5 mM 0.6313 mL 3.1565 mL 6.3129 mL
10 mM 0.3156 mL 1.5782 mL 3.1565 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

316.81

Formula

C₁₆H₁₃ClN₂OS

CAS No.

639052-78-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 45 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
LH846
Cat. No.:
HY-15704
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