1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
  2. Casein Kinase

LH846 

Cat. No.: HY-15704 Purity: 98.02%
Handling Instructions

LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively.

For research use only. We do not sell to patients.
LH846 Chemical Structure

LH846 Chemical Structure

CAS No. : 639052-78-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 77 In-stock
5 mg USD 70 In-stock
10 mg USD 96 In-stock
50 mg USD 300 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively.

IC50 & Target

IC50: 290 nM (CKIδ), 1.3 μM (CKIε), 2.5 μM (CKIα)[1]

In Vitro

LH846 is a potent inhibitor of CKIδ, with an IC50 of 290 nM, less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively, and has no effect on CK2. LH846 (3 or 10 μM) inhibits CKIδ-dependent phosphorylation of PER1 in HEK293T cells[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.1565 mL 15.7823 mL 31.5647 mL
5 mM 0.6313 mL 3.1565 mL 6.3129 mL
10 mM 0.3156 mL 1.5782 mL 3.1565 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

316.81

Formula

C₁₆H₁₃ClN₂OS

CAS No.

639052-78-1

SMILES

O=C(NC1=NC2=CC(Cl)=C(C)C=C2S1)CC3=CC=CC=C3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 45 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
LH846
Cat. No.:
HY-15704
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