A small molecule modulates circadian rhythms through phosphorylation of the period protein

  • Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-11. doi: 10.1002/anie.201103915.
Jae Wook Lee  1 ,  Tsuyoshi Hirota ,  Eric C Peters ,  Michael Garcia ,  Rodolfo Gonzalez ,  Charles Y Cho ,  Xu Wu ,  Peter G Schultz ,  Steve A Kay
Affiliations
  • 1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
PMID: 21954091 DOI: 10.1002/anie.201103915
Abstract

Time shift: A high-throughput cell-based screen identified a benzothiazole analogue, LH846, which induces period lengthening of the circadian rhythm. Affinity chromatography coupled with mass spectrometry and genomic analysis identified protein kinase CKIδ as the biological target of LH846 (see picture).

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