1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
  2. Casein Kinase
  3. BTX161

BTX161 

Cat. No.: HY-120084
Handling Instructions

BTX161, a Thalidomide analog, is a potent CKIα degrader. BTX161 mediates degradation of CKIα better than Lenalidomide in human AML cells and activates DNA damage response (DDR) and p53, while stabilizing the p53 antagonist MDM2.

For research use only. We do not sell to patients.

BTX161 Chemical Structure

BTX161 Chemical Structure

CAS No. : 2052301-24-1

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Description

BTX161, a Thalidomide analog, is a potent CKIα degrader. BTX161 mediates degradation of CKIα better than Lenalidomide in human AML cells and activates DNA damage response (DDR) and p53, while stabilizing the p53 antagonist MDM2[1].

In Vitro

BTX161 (25 μM; 4 hours; MV4-11 cells) upregulates all the Wnt targets including MYC and did not affect MDM2 mRNA expression[1].
BTX161 (10 μM; 6 hours; MV4-11 cells), on its own, augmented p53 and MDM2 protein expression, yet in combination with THZ1, and particularly with both THZ1 and CDK9, further augmented p53 and induced maximal caspase 3 activation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

272.30

Formula

C₁₅H₁₆N₂O₃

CAS No.
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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BTX161
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