2052301-24-1
2052301-24-1
Chemical Structure
BTX161
- CAS No.: 2052301-24-1
- Formula:C15H16N2O3
- Molecular Weight:272.30
IUPAC Name: (S)-3-(4-methyl-1-oxoisoindolin-2-yl)azepane-2,7-dione
InChIKey: CNIZBMYCKRUTHY-LBPRGKRZSA-N
SMILES: O=C([C@@H](N(CC1=C2C=CC=C1C)C2=O)CCC3)NC3=O
Biological Activity: BTX161, a thalidomide analog, is an effective CKIα degrader. BTX161 mediates human AML cell CKIα degradation more effectively than lenalidomide and activates the DNA damage response (DDR) and p53, while stabilizing p53 antagonist MDM2.
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BTX161 | 99.20% | BTX161, a thalidomide analog, is an effective CKIα degrader. BTX161 mediates human AML cell CKIα degradation more effectively than lenalidomide and activates the DNA damage response (DDR) and p53, while stabilizing p53 antagonist MDM2. | ||||||||||||||||||||
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Keywords
