CSNK1E Protein, Human (Active, sf9)
CSNK1E protein is a casein kinase that preferentially phosphorylates acidic proteins such as casein. CSNK1E, Human (Active, sf9) is the recombinant human-derived CSNK1E protein, expressed by sf9 insect cells, with N-Avi labeled tag.
- Species: Human
- Source: sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
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Biological Activity
Description
CSNK1E protein is a casein kinase that preferentially phosphorylates acidic proteins such as casein. CSNK1E, Human (Active, sf9) is the recombinant human-derived CSNK1E protein, expressed by sf9 insect cells, with N-Avi labeled tag.
Background
CSNK1E, a member of the casein kinase family, is characterized by its preferential phosphorylation of acidic proteins, particularly caseins. The protein plays a pivotal role in Wnt signaling, as evidenced by its phosphorylation of DVL1 and DVL2, contributing to the intricate regulation of this pathway. Beyond its involvement in Wnt signaling, CSNK1E serves as a central component of the circadian clock, influencing the circadian period length by orchestrating the speed and rhythmicity of PER1 and PER2 phosphorylation. Acting in equilibrium with PP1, it governs the nuclear transport and degradation of PER1 and PER2, thereby intricately regulating the circadian rhythm. Additionally, CSNK1E demonstrates its regulatory influence by inhibiting cytokine-induced granulocytic differentiation, further emphasizing its multifaceted roles in cellular processes.
Technical Parameters
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Species Human
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Source sf9 insect cells
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Tag Tag Free
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Accession
P49674 (E2-K416)
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Gene ID1454
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Molecular Construction
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N-term
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(E2-K416)
Accession # P49674 -
C-term
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Protein Length
Full Length
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Synonyms
CSNK1E; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase 1 Epsilon; Alternative Protein CSNK1E; CKIepsilon; Casein Kinase 1, Epsilon; HCKIE; CKI-Epsilon; CKIE; CKIe; Casein Kinase I Isoform Epsilon
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AA Sequence
ELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipped with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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