Norquetiapine dihydrochloride
Based on 1 publication(s) in Google Scholar
Norquetiapine ( N-Desalkylauetiapine) dihydrochloride, a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC50 of 13.9 μM. Norquetiapine dihydrochloride selectively inhibits noradrenaline reuptake, is a partial 5-HT1A (Ki = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (Ki = 237 nM), 5-HT2C(Ki = 107 nM), and 5-HT7 (Ki = 76 nM) receptors. Norquetiapine dihydrochloride blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine dihydrochloride shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine dihydrochloride can be used for the study of depression and inflammation.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 111974-74-4
- Formula: C17H19Cl2N3S
- Molecular Weight:368.32
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
-
HY-W040555R
Norquetiapine dihydrochloride (Standard)
-
HY-Y0889
1-(2,3-Dichlorphenyl)piperazine
-
![Dibenzo[b,f][1,4]thiazepin-11(10H)-one (Standard)](https://file.medchemexpress.com/product_pic/hy-i0212r.gif)
HY-I0212R
Dibenzo[b,f][1,4]thiazepin-11(10H)-one (Standard)
-
HY-W105411
N,N'-Diacryloylpiperazine
-
HY-20128
Piperazin-2-one
-
HY-W011726
1-(4-Methoxyphenyl)piperazine hydrochloride
-
HY-W001978
1-(4-Chlorobenzhydryl)piperazine
-
HY-W014552
1-(4-Nitrophenyl)piperazine
-
HY-W016777
2,2'-Piperazine-1,4-diyldiethanol
-
HY-W012426
1-Piperonylpiperazine
-
HY-W015661
3-(Piperazin-1-yl)propan-1-ol
-
HY-I0140
1-(3-Methyl-1-phenyl-5-pyrazolyl)Piperazine
Publications Citing Use of MedChemExpress (MCE) Norquetiapine dihydrochloride
MoreAll 5-HT Receptor Isoforms
More
Biological Activity
Chemical Information
-
CAS No. 111974-74-4
-
Appearance Solid
-
Molecular Weight 368.32
-
Formula C17H19Cl2N3S
-
SMILES
C12=CC=CC=C1N=C(C3=CC=CC=C3S2)N4CCNCC4.Cl.Cl
-
Synonyms
N-Desalkylquetiapine dihydrochloride
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Drug Metab Dispos
2025 Nov;53(11):100169. PMID: 41100927
Purity & Documentation
-
Data Sheet (279 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Kim DH, Park KS, Park SH, Hahn SJ, Choi JS. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Eur J Pharmacol. 2020 Oct 15;885:173532. [Content Brief]
[2]. Jean Jacques A, et al. Inhibition of HCN1 currents by norquetiapine, an active metabolite of the atypical anti-psychotic drug quetiapine. Front Pharmacol. 2024 Oct 7;15:1445509. [Content Brief]
[3]. Jaehne EJ, et al. The effect of the antipsychotic drug quetiapine and its metabolite norquetiapine on acute inflammation, memory and anhedonia. Pharmacol Biochem Behav. 2015 Aug;135:136-44. [Content Brief]
[4]. López-Muñoz F, et al. Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders. Front Psychiatry. 2013 Sep 12;4:102. [Content Brief]
[5]. Jensen NH, et al. N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity. Neuropsychopharmacology. 2008 Sep;33(10):2303-12. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Norquetiapine dihydrochloride Related Classifications
HY-W040555 Related Classifications
Powered by Bioz